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Text
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URL Address
<a href="http://doi.org/10.1016/s0014-2999(97)01473-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(97)01473-8</a>
Pages
131–134
Issue
2
Volume
341
Dublin Core
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Title
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Candyflipping': synergistic discriminative effect of LSD and MDMA.
Publisher
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European journal of pharmacology
Date
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1998
1998-01
Subject
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4-methylenedioxyamphetamine/administration & dosage/*pharmacology; Animal/*drug effects; Animals; Behavior; Discrimination Learning/*drug effects; Drug Synergism; Hallucinogens/administration & dosage/*pharmacology; Lysergic Acid Diethylamide/administration & dosage/*pharmacology; Male; N-Methyl-3; Rats; Serotonin Agents/administration & dosage/*pharmacology
Creator
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Schechter M D
Description
An account of the resource
The co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a prevalence that has allowed for the street terminology 'candyflipping' to describe the combination. Internet sites indicate a significant enhancement of central effects with their simultaneous use. In this preliminary observation, male Fawn-Hooded rats were trained to discriminate 1.5 mg/kg MDMA and were, subsequently, tested with doses of MDMA (0.15 mg/kg) or LSD (0.04 mg/kg) that each produced a saline-like response. Co-administration of these doses of MDMA and LSD synergized to produce a maximal MDMA-like response. The possible mechanism for synergistic action upon central serotonergic neurons is discussed to explain the observed effect.
Identifier
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<a href="http://doi.org/10.1016/s0014-2999(97)01473-8" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(97)01473-8</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
4-methylenedioxyamphetamine/administration & dosage/*pharmacology
Animal/*drug effects
Animals
Behavior
Discrimination Learning/*drug effects
Drug Synergism
European journal of pharmacology
Hallucinogens/administration & dosage/*pharmacology
Lysergic Acid Diethylamide/administration & dosage/*pharmacology
Male
N-Methyl-3
Rats
Schechter M D
Serotonin Agents/administration & dosage/*pharmacology