1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jid.2017.08.034</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
219-227
Issue
1
Volume
138
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Publisher
An entity responsible for making the resource available
The Journal of investigative dermatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
Humans; Male; Animals; Mice; Cell Differentiation; Wound Healing/*physiology; Macrophages/*physiology; Diabetes Mellitus; Cells; Cultured; Inbred C57BL; Animal; Disease Models; Administration; Cutaneous; Cell Communication/*physiology; Eye Proteins/administration & dosage/genetics/*physiology; Membrane Glycoproteins/administration & dosage/genetics/*physiology; Mesenchymal Stem Cells/*physiology; Recombinant Proteins/administration & dosage/genetics/metabolism; Skin/*injuries/metabolism; Type 2/complications/pathology
Creator
An entity primarily responsible for making the resource
Yu Bing; Alboslemy Talib; Safadi Fayez; Kim Min-Ho
Description
An account of the resource
The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited to the site of injury, where they participate in the repair process. Despite considerable understanding of the role of each cell type in the process of wound repair, the nature of the dynamic interplay between these two cell types and how this interaction influences the process of wound repair are not well understood. Here, using an in vivo model of cutaneous wound healing in mice, we provide evidence that GPNMB is functionally important in promoting the recruitment of MSCs to the site of skin injury, which in turn modulates inflammatory responses by directing the M2 polarization of macrophages in acute wound healing. Furthermore, we show that GPNMB activity is impaired in a diabetic wound environment, which is associated with impaired MSC recruitment that is reversed by the topical administration of recombinant GPNMB protein to the wounds of diabetic mice. Our study provides important insight into the crosstalk between macrophages and endogenous MSCs toward wound repair.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">10.1016/j.jid.2017.08.034</a>
2018
Administration
Alboslemy Talib
Animal
Animals
Cell Communication/*physiology
Cell Differentiation
Cells
Cultured
Cutaneous
Diabetes Mellitus
Disease Models
Eye Proteins/administration & dosage/genetics/*physiology
Humans
Inbred C57BL
Kim Min-Ho
Macrophages/*physiology
Male
Membrane Glycoproteins/administration & dosage/genetics/*physiology
Mesenchymal Stem Cells/*physiology
Mice
Recombinant Proteins/administration & dosage/genetics/metabolism
Safadi Fayez
Skin/*injuries/metabolism
The Journal of investigative dermatology
Type 2/complications/pathology
Wound Healing/*physiology
Yu Bing
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.lfs.2014.11.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.lfs.2014.11.011</a>
Pages
25–34
Volume
123
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of inflammation in the aging bones.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-02
Subject
The topic of the resource
*Models; Aging; Aging/*physiology; Animals; Biological; Bone adaptation; Bone and Bones/cytology/immunology/*physiopathology; Bone Marrow Cells/physiology; Bone resorption; Cell Differentiation/*physiology; Cumulative Trauma Disorders/physiopathology; Humans; Inflammation; Inflammation/*physiopathology; Macrophages; Macrophages/*physiology; Osteoblasts; Osteoblasts/*physiology; Osteoclasts; Osteoclasts/*physiology
Creator
An entity primarily responsible for making the resource
Abdelmagid Samir M; Barbe Mary F; Safadi Fayez F
Description
An account of the resource
Chronic inflammation in aging is characterized by increased inflammatory cytokines, bone loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to inherent changes in mesenchymal stem cell (MSC) differentiation, resulting in impaired osteoblastogenesis. Also, the pro-inflammatory cytokines increase with aging, leading to enhanced myelopoiesis and osteoclastogenesis. Bone marrow macrophages (BMMs) play pivotal roles in osteoblast differentiation, the maintenance of hematopoietic stem cells (HSCs), and subsequent bone repair. However, during aging, little is known about the role of macrophages in the differentiation and function of MSC and HSC. Aged mammals have higher circulating pro-inflammatory cytokines than young adults, supporting the hypothesis of increased inflammation with aging. This review will aid in the understanding of the potential role(s) of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in differentiation and function of osteoblasts and osteoclasts in relation to aging.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.lfs.2014.11.011" target="_blank" rel="noreferrer noopener">10.1016/j.lfs.2014.11.011</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Models
2015
Abdelmagid Samir M
Aging
Aging/*physiology
Animals
Barbe Mary F
Biological
Bone adaptation
Bone and Bones/cytology/immunology/*physiopathology
Bone Marrow Cells/physiology
Bone resorption
Cell Differentiation/*physiology
Cumulative Trauma Disorders/physiopathology
Department of Anatomy & Neurobiology
Humans
Inflammation
Inflammation/*physiopathology
Life sciences
Macrophages
Macrophages/*physiology
NEOMED College of Medicine
Osteoblasts
Osteoblasts/*physiology
Osteoclasts
Osteoclasts/*physiology
Safadi Fayez F