Browse Items · NEOMED Bibliography Database

Ethics and micromanaged care.

The ethical foundation on which my medical practice is based was recently shaken by an episode involving the intrusion of managed care into my practice. With the patient's informed consent, I prescribed a medication that I knew would not work.

The electronic medical record in dermatology.

Governmental incentives to stimulate the "meaningful use" of electronic medical records and future disincentives for Medicaid and Medicare provide an impetus for dermatologists to consider adding this technology to their clinical practice.…

Practice Gaps. Skin cancer detection in hair salons: opportunity knocking: comment on "Skin cancer knowledge, attitudes, and behaviors in the salon".

Tags: *Barbering, *Health Knowledge, 2011, Archives of dermatology, Attitudes, Basal Cell/*psychology, Carcinoma, Female, Humans, Male, Melanoma/*psychology, Mostow Eliot N, Practice, Skin Neoplasms/*psychology, Squamous Cell/*psychology

Effect of a standardized pharyngitis treatment protocol on use of antibiotics in a pediatric emergency department.

BACKGROUND: Pharyngitis is a common complaint in pediatric patients. If clinical parameters are used alone, bacterial pathogens will be wrongly implicated in many cases. A nonstandardized approach to the treatment of children with pharyngitis in an…

Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011.

IMPORTANCE: The National Action Plan for Combating Antibiotic-Resistant Bacteria set a goal of reducing inappropriate outpatient antibiotic use by 50% by 2020, but the extent of inappropriate outpatient antibiotic use is unknown. OBJECTIVE: To…

Tags: 2016, Adolescence, Adolescent, Adult, Aged, Ambulatory Care – Statistics and Numerical Data, Ambulatory Care/*statistics & numerical data, Anti-Bacterial Agents/*therapeutic use, Antibiotics – Therapeutic Use, Bartoces Monina, Child, Department of Internal Medicine, Enns Eva A, Female, File Thomas M Jr, Finkelstein Jonathan A, Fleming-Dutra Katherine E, Gerber Jeffrey S, Health Care Surveys, Hersh Adam L, Hicks Lauri A, Human, Humans, Hyun David Y, Inappropriate Prescribing – Statistics and Numerical Data, Inappropriate Prescribing/*statistics & numerical data, Infant, JAMA, Linder Jeffrey A, Lynfield Ruth, Male, Margolis David J, May Larissa S, Merenstein Daniel, Metlay Joshua P, Middle Age, Middle Aged, NEOMED College of Medicine, Newborn, Newland Jason G, Otitis Media, Otitis Media – Drug Therapy, Pharyngitis – Drug Therapy, Pharyngitis/drug therapy, Physicians'/*statistics & numerical data, Piccirillo Jay F, Practice Patterns, Preschool, Prevalence, Respiratory Tract Infections – Drug Therapy, Respiratory Tract Infections/drug therapy, Roberts Rebecca M, Sanchez Guillermo V, Shapiro Daniel J, Suda Katie J, Suppurative/*drug therapy, Surveys, Thomas Ann, United States, Woo Teri Moser, Zetts Rachel M

Recognition of leukemia in skeletal remains: report and comparison of two cases.

Recognition of disease in the archeologic record is facilitated by characterization of the skeletal impact of documented (in life) disease. The present study describes the osteological manifestations of leukemia as identified in the skeletons of two…

Clues potentially distinguishing lytic lesions of multiple myeloma from those of metastatic carcinoma.

This study was conducted to determine whether individual bony lesions are specific for recognizing multiple myeloma and thereby distinguish it from metastatic cancer and leukemia. The lytic skeletal lesions of multiple myeloma are characterized by…

Tags: *Paleopathology, 1998, American journal of physical anthropology, Diagnosis, Differential, Dutour O, Female, Hershkovitz I, Humans, Leukemia/*pathology, Male, Middle Aged, Multiple Myeloma/*pathology, Neoplasm Metastasis/*pathology, Rothschild B M

Age-related size reduction of foramina in the cribriform plate.

Anecdotal evidence suggests that the foramina of the cribriform plate which transmit cranial nerve I decrease in size with age, but this finding has never been supported with quantitative data. It has also been observed that olfactory function…

Quantifying rat pulmonary intravascular mononuclear phagocytes.

Cells of the mononuclear phagocyte system (MPS) protect the host by clearing effete and foreign particulates from the circulation. The current study was designed to identify, quantify, harvest, and provide a partial functional characterization of the…

Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.

Previous studies have implicated human alpha-2-macroglobulin (alpha2M) as a potential regulator of neuronal development and function. Rat alpha-1-macroglobulin (alpha1M) and acute-phase alpha-2-macroglobulin (alpha2M) are murine homologues of human…

NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice.

The ability of hippocampal CA1 basal synapses to express N-methyl-D-aspartate (NMDA) receptor-independent long-term potentiation (non-NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non-NMDA LTP. Non-NMDA LTP in…

Survey of cadaveric donors to a body donation program: 1978-1993.

Body donation files from the Department of Anatomy at Northeastern Ohio Universities College of Medicine were reviewed from the 569 donors used in our program from 1978-1993. The data were entered into a computerized database to evaluate the…

Survey of cadaveric donor application files: 1978-1993.

Information derived from application files of potential cadaveric donors to our body donation program from the period of 1978-1993 was entered into a customized database to assess the characteristics of people contributing to such a program. A total…

Multiple binding sites for [125I]RTI-121 and other cocaine analogs in rat frontal cerebral cortex.

In an effort to identify novel binding sites for cocaine and its analogs, we carried out binding studies with the high-affinity and selective ligand [125I]RTI-121 in rat frontal cortical tissue. Very low densities of binding sites were found.…

Castration differentially alters [3H]nisoxetine binding to norepinephrine uptake sites in olfactory bulb and frontal cortex of male rats.

In the present study, [3H]nisoxetine binding to norepinephrine (NE) uptake sites and [3H]norepinephrine uptake were investigated within olfactory bulb (OB) and frontal cortex homogenates from intact and castrated male rats. Statistically significant…

Tags: *Orchiectomy, 1999, Adrenergic/drug effects/*metabolism, Animals, Boja J W, Dluzen D E, Fluoxetine/*analogs & derivatives/metabolism, Frontal Lobe/drug effects/*metabolism, Kinetics, Male, Norepinephrine/metabolism, Olfactory Bulb/drug effects/*metabolism, Rats, Receptors, Shang Y, Sprague-Dawley, Synapse (New York, N.Y.), Synaptosomes/drug effects/metabolism, Testosterone/pharmacology

Antigenic stimulation and multiple myeloma. A prospective study.

BACKGROUND: A causal relationship between antigenic conditions and multiple myeloma was suggested by case reports. Although controlled studies identified associations with individual conditions, they failed to give overall support to the hypothesis.…

Pseudogout following intraarticular injection of sodium hyaluronate.

Tags: 1998, Altawil B, Arthritis and rheumatism, Chondrocalcinosis/*chemically induced, Contraindications, Humans, Hyaluronic Acid/*adverse effects, Injections, Intra-Articular, Knee Joint/drug effects/physiopathology, Luzar M J, Male, Middle Aged, Osteoarthritis/*drug therapy, Pain/drug therapy

Endocardial surface and atrial morphological changes during development and aging.

Light, scanning, and transmission electron microscopic observations related to morphological changes of the right atrium as well as the atrial endocardium during development (15th embryonic day and 1 day old) and aging (560 days old) in the Syrian…

Tags: *Aging, 1989, Animals, Cricetinae, Electron, Embryonic and Fetal Development, Endocardium/embryology/growth & development/*ultrastructure, Endothelium/ultrastructure, Female, Gilloteaux J, Heart Atria/embryology/growth & development/*ultrastructure, Linz D, Male, Mesocricetus, Microscopy, Microvilli/ultrastructure, Pregnancy, Scanning, The American journal of anatomy

Skeletal clues apparently distinguishing Waldenstrom's macroglobulinemia from multiple myeloma and leukemia.

This study was conducted to characterize macroscopically and by conventional radiography the bony lesions in a case of Waldenstrom's macroglobulinemia and to compare and contrast it with those of the other major hematologic lymphoproliferative…

Tags: 2002, American journal of human biology : the official journal of the Human Biology Council, Bone and Bones/diagnostic imaging/*pathology, Diagnosis, Differential, Humans, Leukemia/*diagnosis/pathology, Male, Middle Aged, Multiple Myeloma/*diagnosis/pathology, Radiography, Rothschild B M, Rothschild C, Ruhli F, Waldenstrom Macroglobulinemia/*diagnosis/pathology

Masseter electromyography during chewing in ring-tailed lemurs (Lemur catta).

We examined masseter recruitment and firing patterns during chewing in four adult ring-tailed lemurs (Lemur catta), using electromyography (EMG). During chewing of tougher foods, the working-side superficial masseter tends to show, on average, 1.7…

Tags: 2006, American journal of physical anthropology, Animals, Bite Force, Electromyography/methods, Female, Hylander William L, Johnson Kirk R, Lemur/*physiology, Male, Masseter Muscle/*physiology, Mastication/*physiology, Neurophysiological/physiology, Recruitment, Vinyard Christopher J, Wall Christine E, Williams Susan H

An interspecific analysis of relative jaw-joint height in primates.

Jaw-joint height (JJH) above the occlusal plane is thought to be influenced by cranial base angle (CBA) and facial angulation during growth. To better understand how JJH relates to midline craniofacial form, we test the hypothesis that relative…

Tags: 2010, American journal of physical anthropology, Analysis of Variance, Animals, Armfield Brooke A, Female, Haplorhini/*anatomy & histology, Male, Phylogeny, Posture/*physiology, Regression Analysis, Skull/anatomy & histology, Strepsirhini/*anatomy & histology, Temporomandibular Joint/*anatomy & histology, Vinyard Christopher J

Angular momentum and arboreal stability in common marmosets (Callithrix jacchus).

Despite the importance that concepts of arboreal stability have in theories of primate locomotor evolution, we currently lack measures of balance performance during primate locomotion. We provide the first quantitative data on locomotor stability in…

Behavioral implications of ontogenetic changes in intrinsic hand and foot proportions in olive baboons (Papio Anubis).

OBJECTIVES: Relatively long digits are considered to enhance grasping performance in primates. We tested whether growth-related changes in intrinsic hand and foot proportions may have behavioral implications for growing animals, by examining whether…

Developments in development: What have we learned from primate locomotor ontogeny?

The importance of locomotion to evolutionary fitness has led to extensive study of primate locomotor behavior, morphology and ecology. Most previous research has focused on adult primates, but in the last few decades, increased attention to locomotor…

Seasonal and Ontogenetic Variation in Subcutaneous Adipose Of the Bowhead Whale (Balaena mysticetus).

Cetacean evolution was shaped by an extraordinary land-to-sea transition in which the ancestors of whales became fully aquatic. As part of this transition, these mammals evolved unusually thick blubber which acts as a metabolic reservoir as well as…

Jaw-Muscle Fiber Architecture and Leverage in the Hard-Object Feeding Sooty Mangabey are not Structured to Facilitate Relatively Large Bite Forces Compared to Other Papionins.

Numerous studies have sought to link craniofacial morphology with behavioral ecology in primates. Extant hard-object feeders have been of particular interest because of their potential to inform our understanding about the diets of early fossil…

A comparison of the full and short versions of the Arthritis Impact Measurement Scales.

This study examined the validity and reliability of full and short versions of the Arthritis Impact Measurement Scales (AIMS). One hundred fifty-five patients with Rheumatoid Arthritis followed at a University Hospital Rheumatology Clinic completed…

Tags: *Disability Evaluation, *Severity of Illness Index, 1991, Abraham N, Activities of Daily Living, Adult, Aged, Alarcon G S, Arthritis, Arthritis care and research : the official journal of the Arthritis Health Professions Association, Austin J S, Bradley L A, Female, Humans, Lorish C D, Male, Middle Aged, Reproducibility of Results, Rheumatoid/*diagnosis/rehabilitation

Ethnic/National origin influence on normal range of motion: comment on the article by Assassi et Al.

Tags: 2015, Academic Medical Centers, Anthropometry, Arthritis & rheumatology (Hoboken, N.J.), Articular/*physiology, Ethnology, Female, Human, Humans, Male, Ohio, Range of Motion, Rothschild Bruce, Spine/*physiology

MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.

OBJECTIVE: Hedgehog (HH) signaling has recently been associated with cartilage degradation in osteoarthritis (OA). Because interleukin-1beta (IL-1beta) has been implicated as a principal instigator of OA, we sought to determine whether

Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western

Immunohistochemical localization of substance P, somatostatin, enkephalin, and serotonin in the spinal cord of the northern leopard frog, Rana pipiens.

Using the indirect antibody peroxidase-antiperoxidase method of Sternberger, we localized substance P (SP), somatostatin (SOM), enkephalin (ENK), and serotonin (5HT, 5-hydroxytryptamine) in the spinal cord of Rana pipiens. This is the first study to…

Tags: 1988, Adli D S, Animals, Cruce W L, Enkephalins/analysis, Ho R H, Immunoenzyme Techniques, Male, Neuropeptides/*analysis, Rana pipiens/anatomy & histology/*metabolism, Rosenthal B M, Serotonin/analysis, Somatostatin/analysis, Spinal Cord/*analysis, Substance P/analysis, The Journal of comparative neurology, Yuen G L

Immunohistochemical localization of serotoninergic, enkephalinergic, and catecholaminergic cells in the brainstem and diencephalon of a cartilaginous fish, Hydrolagus colliei.

We localized serotonin (5-HT), leu-enkephalin (LENK), and tyrosine hydroxylase (TH) immunoreactive cells in the brain of a holocephalian, Hydrolagus colliei, by use of antibodies made in rabbit and the peroxidase-antiperoxidase technique. Only three…

Tags: 1991, Animals, Brain Stem/cytology/*metabolism, Catecholamines/*metabolism, Cruce W L, Diencephalon/cytology/*metabolism, Enkephalins/*metabolism, Female, Fishes/*metabolism, Immunohistochemistry, Male, Neurons/metabolism, Serotonin/*metabolism, Stuesse S L, The Journal of comparative neurology, Tissue Distribution

Phase II study of gefitinib in patients with advanced salivary gland cancers.

BACKGROUND: The purpose of this study was to determine the antitumor activity of the epidermal growth factor receptor (EGFR) inhibitor gefitinib in patients with recurrent/metastatic salivary gland cancer. METHODS: We conducted a phase II study in…

Tags: 2015, 80 and over, Adenocarcinoma/drug therapy/mortality/pathology, adenoid cystic carcinoma, Adenoid Cystic/*drug therapy/mortality/pathology, Adult, Aged, Antineoplastic Agents/*therapeutic use, Blumenschein George R Jr, Carcinoma, Department of Internal Medicine, Disease-Free Survival, Dose-Response Relationship, Drug, Drug Administration Schedule, El-Naggar Adel K, Female, Gefitinib, Glisson Bonnie S, Gonzalez-Angulo Ana M, Head & neck, Humans, Jakob John A, Kies Merrill S, Kupferman Michael E, Lee J Jack, Liu Diane D, Local/*drug therapy/mortality/pathology, Male, Maximum Tolerated Dose, Middle Aged, NEOMED College of Medicine, Neoplasm Invasiveness/pathology, Neoplasm Recurrence, Neoplasm Staging, non-adenoid cystic carcinoma, Prognosis, Quinazolines/*therapeutic use, Remission Induction, response to therapy, salivary gland cancer, Salivary Gland Neoplasms/*drug therapy/mortality/pathology, Survival Analysis, Treatment Outcome

Vocal cord paralysis from prostatic carcinoma metastasizing to the larynx.

According to 1992 Cancer Statistics, prostate carcinoma is once again predicted to be the most common cancer in men, exceeding the incidence of lung cancer. In American men, this cancer is estimated to be the second most frequent cause of cancer…

Tags: 1993, Adenocarcinoma/*pathology/*secondary, Aged, Head & neck, Humans, Laryngeal Neoplasms/*secondary, Male, Park M H, Park Y W, Prostatic Neoplasms/*pathology, Thyroid Cartilage/pathology, Vocal Cord Paralysis/*etiology

Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting…

Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice.

UNLABELLED: Bile acid synthesis not only produces physiological detergents required for intestinal nutrient absorption, but also plays a critical role in regulating hepatic and whole-body metabolic homeostasis. We recently reported that…

All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.

UNLABELLED: Mice deficient in small heterodimer partner (SHP) are protected from diet-induced hepatic steatosis resulting from increased fatty acid oxidation and decreased lipogenesis. The decreased lipogenesis appears to be a direct consequence of…

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.

UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). So far, the underlying mechanism remains poorly understood. Here, we show that hepatic…

Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao

G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice.

Bile acids are signaling molecules that play a critical role in regulation of hepatic metabolic homeostasis by activating nuclear farnesoid X receptor (Fxr) and membrane G-protein-coupled receptor (Takeda G-protein-coupled receptor 5; Tgr5). The role…

Developmental changes in levels of growth hormone mRNA in Zucker rats.

Levels of pituitary growth hormone (GH) messenger RNA (mRNA) were compared in groups of genetically obese (fa/fa) and lean (Fa/-) littermate male Zucker rats at four different ages, 3, 5, 9, and 11 weeks, in order to determine the earliest age at…

Sucrose, But Not Glucose, Blocks IL1-beta-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.

Pathogenesis of osteoarthritis (OA) is multifactorial but interleukin-1beta (IL-1beta) is known to be an important mediator of cartilage degradation. Autophagy is an essential cellular homeostasis mechanism and has been proposed to protect against…

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