1
40
11
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2013/371813</a>
Pages
1–15
Volume
2013
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/β-Catenin Signaling Pathway.
Publisher
An entity responsible for making the resource available
Evidence-based Complementary & Alternative Medicine (eCAM)
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
Immunohistochemistry; Gene Expression; Apoptosis; Rats; Pomegranate; Post Hoc Analysis; One-Way Analysis of Variance; Structural Equation Modeling; Experimental Studies; Protocols; Carcinoma; Blotting; Western; Hepatocellular; Animal Studies; In Vivo Studies
Creator
An entity primarily responsible for making the resource
Bhatia Deepak; Thoppil Roslin J; Mandal Animesh; Samtani Karishma A; Darvesh Altaf S; Bishayee Anupam
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">10.1155/2013/371813</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Animal Studies
Apoptosis
Bhatia Deepak
Bishayee Anupam
Blotting
Carcinoma
Darvesh Altaf S
Department of Pharmaceutical Sciences
Evidence-based Complementary & Alternative Medicine (eCAM)
Experimental Studies
Gene Expression
Hepatocellular
Immunohistochemistry
In Vivo Studies
Mandal Animesh
NEOMED College of Pharmacy
One-Way Analysis of Variance
Pomegranate
Post Hoc Analysis
Protocols
Rats
Samtani Karishma A
STRUCTURAL equation modeling
Thoppil Roslin J
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/nu9050436</a>
Issue
5
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.
Publisher
An entity responsible for making the resource available
Nutrients
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
Female; Animals; Anti-Inflammatory Agents/*pharmacology; Rats; Gene Expression Regulation; Signal Transduction; Apoptosis/drug effects; anti-inflammatory effects; Anticarcinogenic Agents/pharmacology; breast tumor; COX-2; Cyclooxygenase 2/genetics/metabolism; DMBA; HSP90; HSP90 Heat-Shock Proteins/genetics/metabolism; I-kappa B Kinase/genetics/metabolism; NF-E2-Related Factor 2/genetics/*metabolism; NF-kappa B/genetics/*metabolism; NF-kappaB; Nrf2; Plant Preparations/*pharmacology; Punica granatum; Punicaceae/*chemistry; Pomegranate; Chemoprevention; Dose-Response Relationship; Drug; Neoplastic; Mammary Neoplasms; 10-Dimethyl-1; 9; Neoplastic/drug effects; Cell Transformation; 2-benzanthracene/toxicity; Experimental/*prevention & control; Animal Studies; Breast Neoplasms; Inflammation Mediators; Physical Education and Training; Neoplasms – Prevention and Control
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bhatia Deepak; Bishayee Anupam
Description
An account of the resource
Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a striking inhibition of dimethylbenz(a)anthracene (DMBA)-initiated rat mammary tumorigenesis via antiproliferative and apoptosis-inducing mechanisms. The objective of the present work is to investigate the anti-inflammatory mechanism of action of PE during DMBA rat mammary carcinogenesis by evaluating the expression of cyclooxygenase-2 (COX-2), heat shock protein 90 (HSP90), nuclear factor-kappaB (NF-kappaB) and nuclear factor erythroid 2p45 (NF-E2)-related factor 2 (Nrf2). Mammary tumor samples were harvested from our previous chemopreventive study in which PE (0.2-5.0 g/kg) was found to reduce mammary tumorigenesis in a dose-dependent manner. The expressions of COX-2, HSP90, NF-kappaB, inhibitory kappaBalpha (IkappaBalpha) and Nrf2 were detected by immunohistochemical techniques. PE decreased the expression of COX-2 and HSP90, prevented the degradation of IkappaBalpha, hindered the translocation of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">10.3390/nu9050436</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/toxicity
2017
9
Animal Studies
Animals
Anti-Inflammatory Agents/*pharmacology
anti-inflammatory effects
Anticarcinogenic Agents/pharmacology
Apoptosis/drug effects
Bhatia Deepak
Bishayee Anupam
Breast Neoplasms
breast tumor
Cell Transformation
Chemoprevention
COX-2
Cyclooxygenase 2/genetics/metabolism
DMBA
Dose-Response Relationship
Drug
Experimental/*prevention & control
Female
Gene Expression Regulation
HSP90
HSP90 Heat-Shock Proteins/genetics/metabolism
I-kappa B Kinase/genetics/metabolism
Inflammation Mediators
Mammary Neoplasms
Mandal Animesh
Neoplasms – Prevention and Control
Neoplastic
Neoplastic/drug effects
NF-E2-Related Factor 2/genetics/*metabolism
NF-kappa B/genetics/*metabolism
NF-kappaB
Nrf2
Nutrients
Physical Education and Training
Plant Preparations/*pharmacology
Pomegranate
Punica granatum
Punicaceae/*chemistry
Rats
Signal Transduction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/molecules201219853" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/molecules201219853</a>
Pages
22315–22328
Issue
12
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.
Publisher
An entity responsible for making the resource available
Molecules (Basel, Switzerland)
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-12
Subject
The topic of the resource
Female; Animals; Cell Proliferation/drug effects; Rats; DMBA; Punicaceae/*chemistry; Down-Regulation/drug effects; Estrogen Receptor alpha/metabolism; Anticarcinogenic Agents/*pharmacology; beta Catenin/*metabolism; beta-catenin; Breast Neoplasms/*drug therapy/metabolism; Chemoprevention/methods; cyclin D1; estrogen receptors; mammary tumorigenesis; pomegranate (Punica granatum L.); Wnt Proteins/*metabolism; Wnt Signaling Pathway/*drug effects; Sprague-Dawley; Receptors; 10-Dimethyl-1; 9; Cell Transformation; 2-benzanthracene/pharmacology; Estrogen/*metabolism; Neoplastic/drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bishayee Anupam
Description
An account of the resource
A pomegranate emulsion (PE), containing various bioactive phytochemicals, has recently been found to exert substantial chemopreventive effect against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis in rats via antiproliferative and proapoptotic actions. Nevertheless, the underlying mechanisms of action are not completely understood. The present study was designed to investigate the effects of PE treatment on intratumor expression of estrogen receptor (ER)-alpha, ER-beta,beta-catenin and cyclin D1 during DMBA rat mammary carcinogenesis. Mammary tumor sections were harvested from a chemopreventive study in which PE (0.2, 1.0 and 5.0 g/kg) exhibited inhibition of mammary tumorigenesis in a dose-response manner. The expressions of ER-alpha,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/molecules201219853" target="_blank" rel="noreferrer noopener">10.3390/molecules201219853</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/pharmacology
2015
9
Animals
Anticarcinogenic Agents/*pharmacology
beta Catenin/*metabolism
beta-catenin
Bishayee Anupam
Breast Neoplasms/*drug therapy/metabolism
Cell Proliferation/drug effects
Cell Transformation
Chemoprevention/methods
Cyclin D1
DMBA
Down-Regulation/drug effects
Estrogen Receptor alpha/metabolism
estrogen receptors
Estrogen/*metabolism
Female
mammary tumorigenesis
Mandal Animesh
Molecules (Basel, Switzerland)
Neoplastic/drug effects/metabolism
pomegranate (Punica granatum L.)
Punicaceae/*chemistry
Rats
Receptors
Sprague-Dawley
Wnt Proteins/*metabolism
Wnt Signaling Pathway/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/ijms16022426" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/ijms16022426</a>
Pages
2426–2445
Issue
2
Volume
16
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-kappaB and Nrf2 signaling pathways.
Publisher
An entity responsible for making the resource available
International journal of molecular sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-01
Subject
The topic of the resource
Female; Animals; Signal Transduction/*drug effects; Immunohistochemistry; Rats; Up-Regulation/drug effects; NF-kappa B/*metabolism; Aizoaceae/*chemistry/metabolism; Anti-Inflammatory Agents/chemistry/isolation & purification/*pharmacology; Breast Neoplasms/chemically induced/metabolism/pathology; Cyclooxygenase 2/metabolism; HSP90 Heat-Shock Proteins/metabolism; NF-E2-Related Factor 2/*metabolism; Plant Extracts/chemistry; Sprague-Dawley; 10-Dimethyl-1; 9; Plant Components; 2-benzanthracene/toxicity; Aerial/chemistry/metabolism
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bishayee Anupam
Description
An account of the resource
Trianthema portulacastrum, a medicinal and dietary plant, has gained substantial importance due to its various pharmacological properties, including anti-inflammatory and anticarcinogenic activities. We have recently reported that a characterized T. portulacastrum extract (TPE) affords a considerable chemoprevention of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumorigenesis though the underlying mechanisms are not completely understood. The objective of this study was to investigate anti-inflammatory mechanisms of TPE during DMBA mammary carcinogenesis in rats by monitoring cyclooxygenase-2 (COX-2), heat shock protein 90 (HSP90), nuclear factor-kappaB (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (Nrf2). Mammary tumors were harvested from our previous study in which TPE (50-200 mg/kg) was found to inhibit mammary tumorigenesis in a dose-response manner. The expressions of intratumor COX-2, HSP90, NF-kappaB, inhibitory kappaB-alpha (IkappaBalpha) and Nrf2 were determined by immunohistochemistry. TPE downregulated the expression of COX-2 and HSP90, blocked the degradation of IkappaBalpha, hampered the translocation of NF-kappaB from cytosol to nucleus and upregulated the expression and nuclear translocation of Nrf2 during DMBA mammary carcinogenesis. These results in conjunction with our previous findings suggest that TPE prevents DMBA-induced breast neoplasia by anti-inflammatory mechanisms mediated through simultaneous and differential modulation of two interconnected molecular circuits, namely NF-kappaB and Nrf2 signaling pathways.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/ijms16022426" target="_blank" rel="noreferrer noopener">10.3390/ijms16022426</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/toxicity
2015
9
Aerial/chemistry/metabolism
Aizoaceae/*chemistry/metabolism
Animals
Anti-Inflammatory Agents/chemistry/isolation & purification/*pharmacology
Bishayee Anupam
Breast Neoplasms/chemically induced/metabolism/pathology
Cyclooxygenase 2/metabolism
Female
HSP90 Heat-Shock Proteins/metabolism
Immunohistochemistry
International journal of molecular sciences
Mandal Animesh
NF-E2-Related Factor 2/*metabolism
NF-kappa B/*metabolism
Plant Components
Plant Extracts/chemistry
Rats
Signal Transduction/*drug effects
Sprague-Dawley
Up-Regulation/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/13880209.2012.749922" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/13880209.2012.749922</a>
Pages
668–674
Issue
5
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells.
Publisher
An entity responsible for making the resource available
Pharmaceutical biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
Humans; Time Factors; Hep G2 Cells; Desert Climate; Inhibitory Concentration 50; Liver Neoplasms/*drug therapy/pathology; Plant Extracts/administration & dosage/*pharmacology; Tetrazolium Salts/chemistry; Thiazoles/chemistry; Carcinoma; Dose-Response Relationship; Drug; Plants; Antineoplastic Agents; Aerial; Hepatocellular/*drug therapy/pathology; Medicinal/chemistry; Phytogenic/administration & dosage/*pharmacology; Plant Components
Creator
An entity primarily responsible for making the resource
Thoppil Roslin J; Harlev Eli; Mandal Animesh; Nevo Eviatar; Bishayee Anupam
Description
An account of the resource
CONTEXT: Phytochemicals are produced by desert plants to protect themselves against stressful environments. They have been shown to be useful in preventing and fighting adverse pathophysiological conditions and complex diseases, including cancer. Although many desert plants have been investigated for their antitumor properties, a large number of them still remain to be explored for possible therapeutic applications in oncologic diseases. OBJECTIVE: To screen the antitumor effects of selected desert plants, namely Achillea fragrantissima (Forssk.) Sch. Bip. (Compositae), Ochradenus baccatus Delile (Resedaceae), Origanum dayi Post (Lamiaceae), Phlomis platystegia Post (Lamiaceae) and Varthemia iphionoides Boiss (Compositae), against an in vitro tumor model utilizing HepG2 human hepatocellular carcinoma cells. MATERIALS AND METHODS: The aqueous extracts of aerial parts of the aforementioned plants were prepared and used for the in vitro experiments. The HepG2 cells were exposed to varying concentrations (0-4 mg/mL) of each plant extract for 24 or 48 h and the cytotoxicity was measured by the MTT assay. RESULTS: Following 24 h exposure, O. dayi extract exhibited a substantial antiproliferative effect in HepG2 cells (IC50 = 1.0 mg/mL) followed by O. baccatus (IC50 = 1.5 mg/mL). All plant extracts displayed cytotoxicity following 48 h exposure. Nevertheless, a substantial effect was observed with O. dayi (IC50 = 0.35 mg/mL) or O. baccatus (IC50 = 0.83 mg/mL). CONCLUSION: The aqueous extracts from aerial parts of O. dayi and O. baccatus possess antitumor effects against human liver cancer cells. These desert plants represent valuable resources for the development of potential anticancer agents.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/13880209.2012.749922" target="_blank" rel="noreferrer noopener">10.3109/13880209.2012.749922</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Aerial
Antineoplastic Agents
Bishayee Anupam
Carcinoma
Desert Climate
Dose-Response Relationship
Drug
Harlev Eli
Hep G2 Cells
Hepatocellular/*drug therapy/pathology
Humans
Inhibitory Concentration 50
Liver Neoplasms/*drug therapy/pathology
Mandal Animesh
Medicinal/chemistry
Nevo Eviatar
Pharmaceutical biology
Phytogenic/administration & dosage/*pharmacology
Plant Components
Plant Extracts/administration & dosage/*pharmacology
Plants
Tetrazolium Salts/chemistry
Thiazoles/chemistry
Thoppil Roslin J
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2013/371813</a>
Pages
371813–371813
Volume
2013
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ beta -Catenin Signaling Pathway.
Publisher
An entity responsible for making the resource available
Evidence-based complementary and alternative medicine : eCAM
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-07
Creator
An entity primarily responsible for making the resource
Bhatia Deepak; Thoppil Roslin J; Mandal Animesh; Samtani Karishma A; Darvesh Altaf S; Bishayee Anupam
Description
An account of the resource
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, and chemoprevention represents a viable approach in lowering the mortality of this disease. Pomegranate fruit, an abundant source of anti-inflammatory phytochemicals, is gaining tremendous attention for its wide-spectrum health benefits. We previously reported that a characterized pomegranate emulsion (PE) prevents diethylnitrosamine (DENA)-induced rat hepatocarcinogenesis though inhibition of nuclear factor-kappaB (NF- kappa B). Since NF- kappa B concurrently induces Wnt/ beta -catenin signaling implicated in cell proliferation, cell survival, and apoptosis evasion, we examined antiproliferative, apoptosis-inducing and Wnt/ beta -catenin signaling-modulatory mechanisms of PE during DENA rat hepatocarcinogenesis. PE (1 or 10 g/kg) was administered 4 weeks before and 18 weeks following DENA exposure. There was a significant increase in hepatic proliferation (proliferating cell nuclear antigen) and alteration in cell cycle progression (cyclin D1) due to DENA treatment, and PE dose dependently reversed these effects. PE substantially induced apoptosis by upregulating proapoptotic protein Bax and downregulating antiapoptotic protein Bcl-2. PE dose dependently reduced hepatic beta -catenin and augmented glycogen synthase kinase-3 beta expression. Our study provides evidence that pomegranate phytochemicals exert chemoprevention of hepatic cancer through antiproliferative and proapoptotic mechanisms by modulating Wnt/ beta -catenin signaling. PE, thus, targets two interconnected molecular circuits (canonical NF- kappa B and Wnt/ beta -catenin pathways) to exert chemoprevention of HCC.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">10.1155/2013/371813</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Bhatia Deepak
Bishayee Anupam
Darvesh Altaf S
Department of Pharmaceutical Sciences
Evidence-based complementary and alternative medicine : eCAM
Mandal Animesh
NEOMED College of Pharmacy
Samtani Karishma A
Thoppil Roslin J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/01635581.2016.1115094</a>
Pages
120–130
Issue
1
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Publisher
An entity responsible for making the resource available
Nutrition and cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
1905-07
Subject
The topic of the resource
*Punicaceae/chemistry; 10-Dimethyl-1; 2-benzanthracene; 9; Animal Studies; Animals; Anticarcinogenic Agents/*therapeutic use; Apoptosis; Apoptosis/*drug effects; Breast Neoplasms – Mortality; Breast Neoplasms – Prevention and Control; Breast Neoplasms – Risk Factors; Cell Physiology; Cell Proliferation/*drug effects; Diet – Evaluation; Experimental/pathology/*prevention & control; Female; Funding Source; Gene Expression Regulation; Genes; Human; Immunohistochemistry; Mammary Neoplasms; Mutation; National Institutes of Health (U.S.); Neoplasms – Prevention and Control; Phytotherapy; Pomegranate; Proto-Oncogene Proteins c-bcl-2/analysis; Rats; Sprague-Dawley; Tamoxifen; United States
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Mandal Animesh; Bhattacharyya Piyali; Bhatia Deepak
Description
An account of the resource
Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of its various health benefits. This study was initiated to investigate chemopreventive potential of a pomegranate emulsion (PE) against 7,12-dimethylbenz(a)anthracene (DMBA) rat mammary carcinogenesis. The animals were orally administered with PE (0.2-5.0 g/kg), starting 2 wk before and 16 wk following DMBA treatment. PE exhibited a striking reduction of DMBA-induced mammary tumor incidence, total tumor burden, and reversed histopathological changes. PE dose-dependently suppressed cell proliferation and induced apoptosis in mammary tumors. Immunohistochemical studies showed that PE increased intratumor Bax, decreased Bcl2 and manifested a proapoptotic shift in Bax/Bcl2 ratio. In addition, our gene expression study showed PE-mediated upregulation of Bad, caspase-3, caspase-7, caspase-9, poly (ADP ribose) polymerase and cytochrome c in mammary tumors. Thus, PE exerts chemoprevention of mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis mediated through upregulation of Bax and downregulation of Bcl2 in concert with caspase cascades. Pomegranate bioactive phytoconstituents could be developed as a chemopreventive drug to reduce the risk of breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">10.1080/01635581.2016.1115094</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Punicaceae/chemistry
10-Dimethyl-1
2-benzanthracene
2016
9
Animal Studies
Animals
Anticarcinogenic Agents/*therapeutic use
Apoptosis
Apoptosis/*drug effects
Bhatia Deepak
Bhattacharyya Piyali
Bishayee Anupam
Breast Neoplasms – Mortality
Breast Neoplasms – Prevention and Control
Breast Neoplasms – Risk Factors
Cell Physiology
Cell Proliferation/*drug effects
Diet – Evaluation
Experimental/pathology/*prevention & control
Female
Funding Source
Gene Expression Regulation
Genes
Human
Immunohistochemistry
Mammary Neoplasms
Mandal Animesh
Mutation
National Institutes of Health (U.S.)
Neoplasms – Prevention and Control
Nutrition and cancer
Phytotherapy
Pomegranate
Proto-Oncogene Proteins c-bcl-2/analysis
Rats
Sprague-Dawley
Tamoxifen
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/S2095-4964(16)60247-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/S2095-4964(16)60247-9</a>
Pages
84–99
Issue
2
Volume
14
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Health-promoting and disease-preventive potential of Trianthema portulacastrum Linn. (Gadabani) -An Indian medicinal and dietary plant.
Publisher
An entity responsible for making the resource available
Journal of integrative medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-03
Subject
The topic of the resource
*Aizoaceae/chemistry; *Plants; Edible; Health Promotion; Humans; India; Medicinal; Nutritive Value; Plant Extracts/pharmacology/toxicity
Creator
An entity primarily responsible for making the resource
Yamaki Jason; Nagulapalli Venkata Kalyan C; Mandal Animesh; Bhattacharyya Piyali; Bishayee Anupam
Description
An account of the resource
It is estimated that 80% of the world population depends on traditional medicine for primary healthcare need. Trianthema portulacastrum Linn. (family: Aizoaceae) is a small perennial weed found in the Americas, Africa, India, and other regions of the world. This plant is used extensively in Indian traditional medicines and is also consumed as a vegetable throughout Asia for its perceived health benefits. Phytochemical analysis of T. portulacastrum reveals the presence of alkaloids, flavonoids, terpenoids, saponins, and phenolic compounds. Emerging studies demonstrate that crude extracts as well as bioactive phytoconstituents of T. portulacastrum exhibit potent antioxidant, anti-infective, analgesic, and anti-inflammatory activities. A growing number of in vitro and in vivo studies demonstrate various biological and pharmacological activities, including prevention and amelioration of hepatotoxicity, nephrotoxicity, hyperglycemia, hyperlipidemia, infectious diseases and cancer. This review aims to present and analyze available literature to understand the full potential of T. portulacastrum in health promotion and disease prevention. Current limitations and future directions of research on this medicinal and dietary plant are also critically discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/S2095-4964(16)60247-9" target="_blank" rel="noreferrer noopener">10.1016/S2095-4964(16)60247-9</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aizoaceae/chemistry
*Plants
2016
Bhattacharyya Piyali
Bishayee Anupam
Edible
Health Promotion
Humans
India
Journal of integrative medicine
Mandal Animesh
Medicinal
Nagulapalli Venkata Kalyan C
Nutritive Value
Plant Extracts/pharmacology/toxicity
Yamaki Jason
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.mrfmmm.2014.01.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.mrfmmm.2014.01.002</a>
Pages
107–118
Volume
768
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats.
Publisher
An entity responsible for making the resource available
Mutation research
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-10
Subject
The topic of the resource
*Dietary Supplements; *Mammary Neoplasms; 10-Dimethyl-1; 2-benzanthracene/*toxicity; 9; Aizoaceae/*chemistry; Animals; Apoptosis; Bax; Bcl-2; bcl-2-Associated X Protein/metabolism; beta-Catenin; Breast cancer; Carcinogens/*toxicity; Cell proliferation; Cell Proliferation/drug effects; Chemoprevention; Cyclin D1; DMBA; Experimental/chemically induced/metabolism/pathology/prevention & control; Humans; Male; Medicinal/*chemistry; Phytotherapy/*methods; Plants; Proliferating Cell Nuclear Antigen/metabolism; Rats; Sprague-Dawley; Trianthema portulacastrum; Up-Regulation/drug effects; Wnt Signaling Pathway/drug effects
Creator
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Bishayee Anupam; Mandal Animesh
Description
An account of the resource
Due to limited treatment options for advanced-stage metastatic breast cancer, a high priority should be given to develop non-toxic chemopreventive drugs. The value of various natural and dietary agents to reduce the risk of developing breast cancer is well established. Trianthema portulacastrum Linn. (Aizoaceae), a dietary and medicinal plant, has been found to exert antihepatotoxic and antihepatocarcinogenic properties in rodents. This study was initiated to investigate mechanism-based chemopreventive potential of an ethanolic extract of T. portulacastrum (TPE) against 7,12-dimethylbenz(a)anthracene (DMBA)-initiated rat mammary gland carcinogenesis, an experimental tumor model that closely resembles human breast cancer. Rats had access to a basal diet supplemented with TPE to yield three dietary doses of the extract, i.e., 50, 100 and 200 mg/kg body weight. Following two weeks of TPE treatment, mammary tumorigenesis was initiated by oral administration of DMBA (50 mg/kg body weight). At the end of the study (16 weeks after DMBA exposure), TPE exhibited a striking reduction of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.mrfmmm.2014.01.002" target="_blank" rel="noreferrer noopener">10.1016/j.mrfmmm.2014.01.002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Dietary Supplements
*Mammary Neoplasms
10-Dimethyl-1
2-benzanthracene/*toxicity
2014
9
Aizoaceae/*chemistry
Animals
Apoptosis
Bax
Bcl-2
bcl-2-Associated X Protein/metabolism
beta-catenin
Bishayee Anupam
breast cancer
Carcinogens/*toxicity
Cell Proliferation
Cell Proliferation/drug effects
Chemoprevention
Cyclin D1
DMBA
Experimental/chemically induced/metabolism/pathology/prevention & control
Humans
Male
Mandal Animesh
Medicinal/*chemistry
Mutation research
Phytotherapy/*methods
Plants
Proliferating Cell Nuclear Antigen/metabolism
Rats
Sprague-Dawley
Trianthema portulacastrum
Up-Regulation/drug effects
Wnt Signaling Pathway/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11101-014-9337-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11101-014-9337-5</a>
Pages
793–810
Issue
4
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives.
Publisher
An entity responsible for making the resource available
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-12
Subject
The topic of the resource
Chemoprevention; Mammary cancer; Oleanolic acid; Synthetic oleananes; Treatment
Creator
An entity primarily responsible for making the resource
Parikh Nisha R; Mandal Animesh; Bhatia Deepak; Siveen Kodappully Sivaraman; Sethi Gautam; Bishayee Anupam
Description
An account of the resource
Breast cancer is one of the most frequently diagnosed cancers and major cause of death in women in the world. Emerging evidence underscores the value of dietary and non-dietary phytochemicals, including triterpenoids, in the prevention and treatment of breast cancer. Oleanolic acid, an oleanane-type pentacyclic triterpenoid, is present in a large number of dietary and medicinal plants. Oleanolic acid and its derivatives exhibit several promising pharmacological activities, including antioxidant, anti-inflammatory, hepatoprotective, cardioprotective, antipruritic, spasmolytic, antiallergic, antimicrobial and antiviral effects. Numerous studies indicate that oleanolic acid and other oleanane triterpenoids modulate multiple intracellular signaling pathways and exert chemopreventive and antitumor activities in various in vitro and in vivo model systems. A series of novel synthetic oleanane triterpenoids have been prepared by chemical modifications of oleanolic acid and some of these compounds are considered to be the most potent anti-inflammatory and anticarcinogenic triterpenoids. Accumulating studies provide extensive evidence that synthetic oleanane derivatives inhibit proliferation and induce apoptosis of various cancer cells in vitro and demonstrate cancer preventive or antitumor efficacy in animal models of blood, breast, colon, connective tissue, liver, lung, pancreas, prostate and skin cancer. This review critically examines the potential role of oleanolic acid, oleanane triterpenoids and related synthetic compounds in the chemoprevention and treatment of mammary neoplasia. Both in vitro and in vivo studies on these agents and related molecular mechanisms are presented. Several challenges and future directions of research to translate already available impressive preclinical knowledge to clinical practice of breast cancer prevention and therapy are also presented.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11101-014-9337-5" target="_blank" rel="noreferrer noopener">10.1007/s11101-014-9337-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Bhatia Deepak
Bishayee Anupam
Chemoprevention
Mammary cancer
Mandal Animesh
Oleanolic acid
Parikh Nisha R
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe
Sethi Gautam
Siveen Kodappully Sivaraman
Synthetic oleananes
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/mc.22067" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/mc.22067</a>
Pages
999–1010
Issue
12
Volume
53
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.
Publisher
An entity responsible for making the resource available
Molecular carcinogenesis
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-12
Subject
The topic of the resource
Animals; Anti-Inflammatory Agents/pharmacology; Anticarcinogenic Agents/*pharmacology; Antineoplastic Agents/*pharmacology; Apoptosis/drug effects; Breast Neoplasms/*drug therapy/metabolism; breast tumor; Carcinogenesis/*drug effects; Cell Proliferation/drug effects; Chemoprevention/methods; COX-2; Cyclooxygenase 2/metabolism; DMBA; Down-Regulation/drug effects; Experimental/*drug therapy/metabolism; Female; HSP90; HSP90 Heat-Shock Proteins/metabolism; I-kappa B Proteins/metabolism; inflammation; Inflammation/*drug therapy/metabolism; Mammary Neoplasms; NF-kappa B/metabolism; NF-kappaB; NF-KappaB Inhibitor alpha; oleanane triterpenoid; Oleanolic Acid/*analogs & derivatives/pharmacology; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bhatia Deepak; Bishayee Anupam
Description
An account of the resource
Breast cancer represents the second leading cause of cancer-related deaths among women worldwide and preventive therapy could reverse or delay the devastating impact of this disease. Methyl-amooranin (methyl-25-hydroxy-3-oxoolean-12-en-28-oate, AMR-Me), a novel synthetic oleanane triterpenoid, reduced the incidence and burden of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats through antiproliferative and proapoptotic effects. Since chronic inflammation plays an important role in the pathogenesis of breast cancer and several synthetic oleanane compounds are known potent anti-inflammatory agents, we aim to investigate anti-inflammatory mechanisms of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/mc.22067" target="_blank" rel="noreferrer noopener">10.1002/mc.22067</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Anti-Inflammatory Agents/pharmacology
Anticarcinogenic Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/drug effects
Bhatia Deepak
Bishayee Anupam
Breast Neoplasms/*drug therapy/metabolism
breast tumor
Carcinogenesis/*drug effects
Cell Proliferation/drug effects
Chemoprevention/methods
COX-2
Cyclooxygenase 2/metabolism
DMBA
Down-Regulation/drug effects
Experimental/*drug therapy/metabolism
Female
HSP90
HSP90 Heat-Shock Proteins/metabolism
I-kappa B Proteins/metabolism
Inflammation
Inflammation/*drug therapy/metabolism
Mammary Neoplasms
Mandal Animesh
Molecular carcinogenesis
NF-kappa B/metabolism
NF-kappaB
NF-KappaB Inhibitor alpha
oleanane triterpenoid
Oleanolic Acid/*analogs & derivatives/pharmacology
Rats
Sprague-Dawley