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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ajcp/109.5.558" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ajcp/109.5.558</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
558-564
Issue
5
Volume
109
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Dublin Core
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Title
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Histopathologic changes are not specific for diagnosis of gastric antral vascular ectasia (GAVE) syndrome - A review of the pathogenesis and a comparative image analysis morphometric study of GAVE syndrome and gastric hyperplastic polyps
Publisher
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American Journal of Clinical Pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-05
Subject
The topic of the resource
cirrhosis; endoscopic laser therapy; gastroduodenal; GAVE syndrome; hyperplastic polyps; intussusception; Pathology; portal hypertensive gastropathy; portal-hypertension; prolapse; watermelon stomach
Creator
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Vesoulis Z; Naik N; Maseelall P
Description
An account of the resource
We studied the nonspecific nature of the histologic findings in the gastric antral vascular ectasia (GAVE) syndrome by using a morphometric comparison with common gastric lesions including hyperplastic polyps and gastritis. Five clinicopathologically confirmed cases of GAVE syndrome and 41 cases of gastric hyperplastic polyps were diagnosed during a 5-year interval at Summa Health Systems (Akron, Ohio). These cases, as well as 16 randomly selected cases of nonspecific gastritis and 9 normal gastric antral biopsy specimens, were evaluated. A semiquantitative comparison of the light microscopic findings believed to be essential in diagnosis of GAVE syndrome, including vascular hyperplasia, mucosal vascular ectasia, intravascular fibrin thrombi, and fibromuscular hyperplasia, was performed. Image analysis morphometric measures of the area ratio (vascular area/total biopsy area), mean vascular area, and number of ectatic vessels per square millimeter of tissue were performed on the CAS 200 Image Analyzer (Becton Dickinson, San Jose, Calif). By morphometric and statistical parametric analysis, several histopathologic variables, including area ratio, mean vascular area, mucosal vascular ectasia, and fibromuscular hyperplasia, did not confidently differentiate the histologic features of gastric hyperplastic polyp from those of GAVE syndrome, but did apparently differentiate GAVE syndrome from gastritis and normal gastric mucosa. The propensity of gastric hyperplastic polyps to undergo prolapse changes and prolapse as one proposed mechanism for development of the GAVE syndrome lesion probably accounts for this morphologic similarity. Specific diagnostic histopathologic changes probably do not exist for the GAVE syndrome.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ajcp/109.5.558" target="_blank" rel="noreferrer noopener">10.1093/ajcp/109.5.558</a>
Format
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Journal Article
1998
American journal of clinical pathology
Cirrhosis
endoscopic laser therapy
gastroduodenal
GAVE syndrome
hyperplastic polyps
intussusception
Journal Article
Maseelall P
Naik N
Pathology
portal hypertensive gastropathy
portal-hypertension
Prolapse
Vesoulis Z
watermelon stomach
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ajog.2004.12.032" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajog.2004.12.032</a>
Pages
1365–1367
Issue
5
Volume
192
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Carboplatin and paclitaxel for the treatment of advanced or recurrent endometrial cancer.
Publisher
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American Journal of Obstetrics & Gynecology
Date
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2005
2005-05
Subject
The topic of the resource
Adult; Aged; Survival; Drug Administration Schedule; Human; Middle Age; Retrospective Design; Neoplasm Recurrence; Antineoplastic Agents; Combined; Kaplan-Meier Estimator; Drug Toxicity; Severity of Illness; Carboplatin – Administration and Dosage; Endometrial Neoplasms – Drug Therapy; Local – Drug Therapy; Paclitaxel – Administration and Dosage
Creator
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Akram T; Maseelall P; Fanning J
Description
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OBJECTIVE: The purpose of this study was to determine the activity and toxicity of carboplatin and paclitaxel (taxol) in the treatment of advanced or recurrent endometrial cancer. STUDY DESIGN: This was a retrospective review of 18 consecutive patients with advanced (stage 4) or recurrent endometrial adenocarcinoma that had been treated with outpatient carboplatin and taxol. Taxol was delivered at 135 mg/m 2 over 3 hours, and carboplatin was delivery at an area under the curve of 5 over 1 hour. Cycles were repeated every 21 days. RESULTS: The overall response rate was 63% with 28% of patients who had a partial response and 35% of patients who had a complete response. Kaplan-Meier test was used to estimate the median survival time of 27 months and the median progression free survival time of 24 months. No patient had neutropenia, thrombocytopenia or grade 3 vomiting, neurosensory toxicity, or renal toxicity. CONCLUSION: Carboplatin and taxol for the treatment of advanced or recurrent endometrial cancer appear to be active regimens with minimal toxicity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ajog.2004.12.032" target="_blank" rel="noreferrer noopener">10.1016/j.ajog.2004.12.032</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Adult
Aged
Akram T
American Journal of Obstetrics & Gynecology
Antineoplastic Agents
Carboplatin – Administration and Dosage
Combined
Drug Administration Schedule
Drug Toxicity
Endometrial Neoplasms – Drug Therapy
Fanning J
Human
Kaplan-Meier Estimator
Local – Drug Therapy
Maseelall P
Middle Age
Neoplasm Recurrence
Paclitaxel – Administration and Dosage
Retrospective Design
Severity of Illness
Survival