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Text
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URL Address
<a href="http://doi.org/10.1016/s0024-3205(00)00658-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(00)00658-5</a>
Pages
643–650
Issue
6
Volume
67
Dublin Core
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Title
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Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning.
Publisher
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Life sciences
Date
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2000
2000-06
Subject
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Animal/drug effects; Animals; Behavior; Cues; Excitatory Amino Acid Agonists/*toxicity; GABA Modulators/*pharmacology; Kainic Acid/*antagonists & inhibitors/*toxicity; Learning/drug effects; Long-Evans; Male; Maze Learning/*drug effects; Memory/drug effects; Phenobarbital/*pharmacology; Rats; Seizures/chemically induced/prevention & control
Creator
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Brown-Croyts L M; Caton P W; Radecki D T; McPherson S L
Description
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This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observed as an increase in latency to a hidden escape platform. Daily phenobarbital treatment (20 mg/kg i.p.) initiated 45 minutes prior to the kainic acid injection blocked the kainic acid-induced deficits in acquisition learning. When daily phenobarbital treatment was initiated 2-3 hours after kainic acid seizure development it did not block the kainic acid induced-deficits in water maze performance. Daily administration of phenobarbital alone at the moderate concentration used in this study did not cause alterations in behavioral performance in the Morris water maze. These studies indicate that phenobarbital pre-treatment results in a behavioral neuroprotection against kainic acid-induced neurotoxicity.
Identifier
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<a href="http://doi.org/10.1016/s0024-3205(00)00658-5" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(00)00658-5</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Animal/drug effects
Animals
Behavior
Brown-Croyts L M
Caton P W
Cues
Excitatory Amino Acid Agonists/*toxicity
GABA Modulators/*pharmacology
Kainic Acid/*antagonists & inhibitors/*toxicity
Learning/drug effects
Life sciences
Long-Evans
Male
Maze Learning/*drug effects
McPherson S L
Memory/drug effects
Phenobarbital/*pharmacology
Radecki D T
Rats
Seizures/chemically induced/prevention & control