Waxy keratoses of childhood in a segmental distribution.
Child; Diagnosis; Differential; Female; Humans; Keratosis/diagnosis/*genetics/pathology
Waxy keratoses of childhood is a rare genodermatosis previously noted in both familial and isolated presentations. Three previous cases have been described in which the lesions appeared over the trunk and extremities. We report a case in which the waxy keratoses of childhood lesions appeared in a segmental distribution along a single lower extremity, differing from the more extensive patterns reported previously. We suggest a possible postzygotic mutation hypothesis for this unique segmental distribution, addressing both the possibility of a genomic mosaicism and loss of heterozygosity.
Mehrabi D; Thomas J E; Selim M A; Prose N S
Pediatric dermatology
2001
2001-10
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1046/j.1525-1470.2001.01968.x" target="_blank" rel="noreferrer noopener">10.1046/j.1525-1470.2001.01968.x</a>
Underlying causes of erythema nodosum. Lesions may provide clue to systemic disease.
Adult; Female; Humans; Pregnancy; Anti-Inflammatory Agents/therapeutic use; *Erythema Nodosum/diagnosis/drug therapy/etiology; Clobetasol/*analogs & derivatives/therapeutic use; Glucocorticoids; Pregnancy Complications; Administration; Topical; Contraceptives; Oral/adverse effects
Brodell R T; Mehrabi D
Postgraduate medicine
2000
2000-11
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.3810/pgm.2000.11.1303" target="_blank" rel="noreferrer noopener">10.3810/pgm.2000.11.1303</a>
Use of the alexandrite laser for treatment of seborrheic keratoses
Dermatology; Surgery; warts; pulsed dye-laser
Seborrheic karatoses are benign lesions that are easily irritated and often cosmetically objectionable. Liquid nitrogen cryotherapy and other surgical methods are useful in treating these lesions, but are difficult to tolerate in patients who have large numbers of lesions requiring treatment. The alexandrite laser was used in one patient to quickly and efficiently destroy hundreds of seborrheic keratoses. The treatment was tolerable and excellent cosmetic results were achieved.
Mehrabi D; Brodell R T
Dermatologic Surgery
2002
2002-05
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1046/j.1524-4725.2002.01213.x" target="_blank" rel="noreferrer noopener">10.1046/j.1524-4725.2002.01213.x</a>
Removal of keratinous and pilar cysts with the punch incision technique: Analysis of surgical outcomes
Dermatology; Surgery
BACKGROUND. The removal of keratinous and pilar cysts by the punch incision technique is an alternative to traditional excision methods. It is easy to perform with commonly available instruments, and quick. Faster healing and less scarring are advantages because of the small opening through which the cysts are removed. No previous studies have documented recurrence rates of cysts removed by this technique or the recurrence rates following either traditional excision surgery or other alternative minimal excision techniques. We provide data demonstrating that the removal of keratinous and pilar cysts by the punch incision technique is a viable option with an acceptably low recurrence rate. OBJECTIVE. To evaluate the overall recurrence rates of keratinous and pilar cysts removed by the punch incision technique and rates of recurrence by location and using other cyst characteristics. METHODS. A preliminary retrospective chart review of cysts removed exclusively by the punch incision technique from 1989 to 1998 was performed. The rate of cyst recurrence and average time to patient-initiated follow-up visit for evaluation and removal were determined. In a second study, a survey requested information on the presence of cyst recurrence. This was mailed to all 646 patients who had cysts removed by the punch incision technique from 1989 to 1998 to evaluate possible cyst recurrence in patients who did not choose to follow-up at the office. Statistical analysis was performed to determine the overall recurrence rates and recurrence rates based on location and other cyst characteristics. RESULTS. Preliminary chart review revealed a recurrence rate of 3.6%, with a mean time to patient-initiated follow-up of 79.3 weeks. In the second study, an analysis of cyst recurrence rates in patients returning the survey revealed an 8.3% recurrence rate. Subanalysis revealed a trend showing that inflamed cysts had a lower recurrence rate. Another trend noted was that cysts removed from the back and ear had the highest recurrence rates (13.8 and 13.0%, respectively) compared to those removed from other locations. Most cysts (54.5%) recurred within the first year after punch incision removal. CONCLUSION. This is the first study to document recurrence rates using the punch incision technique for removal of epithelial cysts. Though most recurrences occur within the first year, there is a delay in patients reporting to their doctors for reexcision, perhaps because recurrent cysts are often asymptomatic. Studies to determine the recurrence rates for cyst excision using other techniques should be performed. The punch incision technique, when properly performed, is a satisfactory removal method with a recurrence rate of less then 10%.
Mehrabi D; Leonhardt J M; Brodell R T
Dermatologic Surgery
2002
2002-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1046/j.1524-4725.2002.02020.x" target="_blank" rel="noreferrer noopener">10.1046/j.1524-4725.2002.02020.x</a>