Infusion of iodine-based contrast agents into poly(p-dioxanone) as a radiopaque resorbable IVC filter
degradation; Engineering; in-vivo; Materials Science; release; triclosan; vena-cava filters
To determine the feasibility of infusing resorbable inferior vena cava (IVC) filter with iodine-based contrast agents to produce a radiopaque, computed tomography (CT)-visible IVC filter. Infused poly(p-dioxanone) (PPDO) was obtained by incubating PPDO in different concentrations of 4-iodobenzoyl chloride (IBC) and 2,3,5-triiodobenzoic acid (TIBA). Characterizations of infused and nascent PPDO were done using elemental analysis, micro-CT, tensile strength analysis, scanning electron microscopy, and differential scanning calorimetry. Elemental analysis showed percentage loading of 1.07 +/- 0.08 for IBC and 0.73 +/- 0.01 for TIBA. The iodine loading remained the same within 2 weeks for TIBA but decreased to about 80 % with IBC when subjected to physiological conditions. Micro-CT images showed increased attenuation of the infused PPDO compared with the nascent PPDO. The Hounsfield unit values for infused and nascent sutures were 110 +/- 40 and 153 +/- 53 for PPDO infused with 2 mg/mL IBC and TIBA, respectively, but only 11.35 +/- 2 for nascent PPDO. In contrast the HU for bone was 116 +/- 37. Tensile strength analysis showed maximum loads of 1.01 +/- 0.43 kg and 10.02 +/- 0.54 kg for IBC and TIBA, respectively, and 10.10 +/- 0.64 kg for nascent PPDO. Scanning electron microscopy showed that the morphology of the PPDO surface did not change after coating and preliminary cytotoxicity assay showed no killing effect on Hela cells. PPDO infused with a contrast agent is significantly more radiopaque than nascent PPDO on micro-CT imaging. This radiopacity could allow the position and integrity of infused resorbable IVC filter to be monitored while it is in place, thus increasing its safety and efficacy as a medical device.
Singhana B; Chen A; Slattery P; Yazdi I K; Qiao Y; Tasciotti E; Wallace M; Huang S; Eggers M; Melancon M P
Journal of Materials Science-Materials in Medicine
2015
2015-03
Journal Article
<a href="http://doi.org/10.1007/s10856-015-5460-0" target="_blank" rel="noreferrer noopener">10.1007/s10856-015-5460-0</a>
Light-Activatable Gold Nanoshells for Drug Delivery Applications
cancer nanotheranostics; drug delivery; gold nanoshells; growth-factor receptor; in-vitro; nanocarrier; nanoparticles; nf-kappa-b; Pharmacology & Pharmacy; photothermal-chemotherapy; release; surface-plasmon resonance; targeted delivery; theranostics; thermal therapy; triggered; triggered release
Gold nanoshells (AuNSs) are currently being investigated as nanocarriers for drug delivery systems and have both diagnostic and therapeutic applications, including photothermal ablation, hyperthermia, drug delivery, and diagnostic imaging, particularly in oncology. AuNSs are valuable for their localized surface plasmon resonance, biocompatibility, low immunogenicity, and facile functionalization. AuNSs used for drug delivery can be spatially and temporally triggered to release controlled quantities of drugs inside the target cells when illuminated with a near-infrared (NIR) laser. Recently, many research groups have demonstrated that these AuNS complexes are able to deliver antitumor drugs (e.g., doxorubicin, paclitaxel, small interfering RNA, and single-stranded DNA) into cancer cells, which enhances the efficacy of treatment. AuNSs can also be functionalized with active targeting ligands such as antibodies, aptamers, and peptides to increase the particles' specific binding to the desired targets. This article reviews the current research on NIR light-activatable AuNSs used as nanocarriers for drug delivery systems and cancer theranostics.
Singhana B; Slattery P; Chen A; Wallace M; Melancon M P
Aaps Pharmscitech
2014
2014-06
Journal Article
<a href="http://doi.org/10.1208/s12249-014-0097-8" target="_blank" rel="noreferrer noopener">10.1208/s12249-014-0097-8</a>