1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jid.2017.08.034</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 219-227 Issue 1 Volume 138 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair. Publisher An entity responsible for making the resource available The Journal of investigative dermatology Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-01 Subject The topic of the resource Humans; Male; Animals; Mice; Cell Differentiation; Wound Healing/*physiology; Macrophages/*physiology; Diabetes Mellitus; Cells; Cultured; Inbred C57BL; Animal; Disease Models; Administration; Cutaneous; Cell Communication/*physiology; Eye Proteins/administration & dosage/genetics/*physiology; Membrane Glycoproteins/administration & dosage/genetics/*physiology; Mesenchymal Stem Cells/*physiology; Recombinant Proteins/administration & dosage/genetics/metabolism; Skin/*injuries/metabolism; Type 2/complications/pathology Creator An entity primarily responsible for making the resource Yu Bing; Alboslemy Talib; Safadi Fayez; Kim Min-Ho Description An account of the resource The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited to the site of injury, where they participate in the repair process. Despite considerable understanding of the role of each cell type in the process of wound repair, the nature of the dynamic interplay between these two cell types and how this interaction influences the process of wound repair are not well understood. Here, using an in vivo model of cutaneous wound healing in mice, we provide evidence that GPNMB is functionally important in promoting the recruitment of MSCs to the site of skin injury, which in turn modulates inflammatory responses by directing the M2 polarization of macrophages in acute wound healing. Furthermore, we show that GPNMB activity is impaired in a diabetic wound environment, which is associated with impaired MSC recruitment that is reversed by the topical administration of recombinant GPNMB protein to the wounds of diabetic mice. Our study provides important insight into the crosstalk between macrophages and endogenous MSCs toward wound repair. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">10.1016/j.jid.2017.08.034</a> 2018 Administration Alboslemy Talib Animal Animals Cell Communication/*physiology Cell Differentiation Cells Cultured Cutaneous Diabetes Mellitus Disease Models Eye Proteins/administration & dosage/genetics/*physiology Humans Inbred C57BL Kim Min-Ho Macrophages/*physiology Male Membrane Glycoproteins/administration & dosage/genetics/*physiology Mesenchymal Stem Cells/*physiology Mice Recombinant Proteins/administration & dosage/genetics/metabolism Safadi Fayez Skin/*injuries/metabolism The Journal of investigative dermatology Type 2/complications/pathology Wound Healing/*physiology Yu Bing