1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a> Pages 7027-7042 Issue 37 Volume 40 ISSN 2706474 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: </a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number September 2020 List NEOMED College NEOMED College of Medicine Postdoc NEOMED Department NEOMED Postdoc Publications Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mechanisms underlying enhancement of spontaneous glutamate release by group I mGluRs at a central auditory synapse Publisher An entity responsible for making the resource available Journal Of Neuroscience Date A point or period of time associated with an event in the lifecycle of the resource 2020 2020-09-09 Subject The topic of the resource SYNAPTIC vesicles; auditory; mGluR; MNTB; EPSC; spontaneous glutamate release; voltage-gated sodium channel; DIRECTIONAL hearing; GLUTAMIC acid; MEMBRANE potential; SYNAPSES Creator An entity primarily responsible for making the resource Kang P;Wang X;Yuan W;Dainan L;Hai H;Yong L Description An account of the resource One emerging concept in neuroscience states that synaptic vesicles and the molecular machinery underlying spontaneous transmitter release are different from those underlying action potential-driven synchronized transmitter release. Differential neuromodulation of these two distinct release modes by metabotropic glutamate receptors (mGluRs) constitutes critical supporting evidence. However, the mechanisms underlying such a differential modulation are not understood. Here, we investigated the mechanisms of the modulation by group I mGluRs (mGluR I) on spontaneous glutamate release in the medial nucleus of the trapezoid body (MNTB), an auditory brainstem nucleus critically involved in sound localization. Whole-cell patch recordings from brainstem slices of mice of both sexes were performed. Activation of mGluR I by 3,5-DHPG (200 μM) produced an inward current at -60 mV, and increased spontaneous glutamate release in MNTB neurons. Pharmacological evidence indicated involvement of both mGluR1 and mGluR5, which was further supported for mGluR5 by immunolabeling results. The modulation was eliminated by blocking NaV channels (tetrodotoxin, 1 μM), persistent Na+ current (INaP) (Riluzole, 10 μM), or CaV channels (CdCl2, 100 µM). Presynaptic calyx recordings revealed that 3,5-DHPG shifted the activation of INaP to more hyperpolarized voltages and increased INaP at resting membrane potential. Our data indicate that mGluR I enhance spontaneous glutamate release via regulation of INaP and subsequent Ca2+-dependent processes under rest condition. [ABSTRACT FROM AUTHOR] Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2020 Auditory Dainan L directional hearing EPSC Glutamic Acid Hai H Journal of Neuroscience journalArticle Kang P Membrane Potential mGluR MNTB NEOMED College of Medicine Postdoc NEOMED Postdoc Publications September 2020 List spontaneous glutamate release synapses SYNAPTIC vesicles voltage-gated sodium channel Wang X Yong L Yuan W Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1166/jbn.2012.1361" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jbn.2012.1361</a> Pages 161–171 Issue 1 Volume 8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antitumor effect of novel gallium compounds and efficacy of nanoparticle-mediated gallium delivery in lung cancer. Publisher An entity responsible for making the resource available Journal of biomedical nanotechnology Date A point or period of time associated with an event in the lifecycle of the resource 2012 2012-02 Subject The topic of the resource Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics; Biocompatible Materials/administration & dosage/chemistry/pharmacokinetics; Cell Line; Cell Survival/drug effects; Coordination Complexes/*administration & dosage/chemistry/pharmacokinetics; Drug Carriers/administration & dosage/chemistry; Drug Stability; Endocytosis/drug effects; Gallium/*administration & dosage/chemistry/pharmacokinetics; Hemolysis/drug effects; Humans; Lung Neoplasms/*drug therapy/metabolism; Materials Testing; Membrane Potential; Mitochondrial/drug effects; Nanoparticles/*administration & dosage/chemistry; Particle Size; Platelet Aggregation/drug effects; Reactive Oxygen Species/metabolism; Transferrin/chemistry/pharmacology; Tumor Creator An entity primarily responsible for making the resource Wehrung Daniel; Oyewumi Moses O Description An account of the resource The widespread application of gallium (Ga) in cancer therapy has been greatly hampered by lack of specificity resulting in poor tumor accumulation and retention. To address the challenge, two lipophilic gallium (III) compounds (gallium hexanedione; GaH and gallium acetylacetonate; GaAcAc) were synthesized and antitumor studies were conducted in human lung adenocarcinoma (A549) cells. Nanoparticles (NPs) containing various concentrations of the Ga compounds were prepared using a binary mixture of Gelucire 44/14 and cetyl alcohol as matrix materials. NPs were characterized based on size, morphology, stability and biocompatibility. Antitumor effects of free or NP-loaded Ga compounds were investigated based on cell viability, production of reactive oxygen species and reduction of mitochondrial potential. Compared to free Ga compounds, cytotoxicity of NP-loaded Ga (5-150 microg/ml) was less dependent on concentration and incubation time (exposure) with A549 cells. NP-mediated delivery (5-150 microg Ga/ml) enhanced antitumor effects of Ga compounds and the effect was pronounced at: (i) shorter incubation times; and (ii) at low concentrations of gallium (approximately 50 microg/ml) (p \textless 0.0006). Additional studies showed that Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1166/jbn.2012.1361" target="_blank" rel="noreferrer noopener">10.1166/jbn.2012.1361</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2012 Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics Biocompatible Materials/administration & dosage/chemistry/pharmacokinetics Cell Line Cell Survival/drug effects Coordination Complexes/*administration & dosage/chemistry/pharmacokinetics Department of Pharmaceutical Sciences Drug Carriers/administration & dosage/chemistry Drug Stability Endocytosis/drug effects Gallium/*administration & dosage/chemistry/pharmacokinetics Hemolysis/drug effects Humans Journal of biomedical nanotechnology Lung Neoplasms/*drug therapy/metabolism Materials Testing Membrane Potential Mitochondrial/drug effects Nanoparticles/*administration & dosage/chemistry NEOMED College of Pharmacy Oyewumi Moses O Particle Size Platelet Aggregation/drug effects Reactive Oxygen Species/metabolism Transferrin/chemistry/pharmacology Tumor Wehrung Daniel