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Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.

Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has emerged as a novel form of neural inhibition in the CNS. However, little is known about its presence and function in the auditory system. Using whole-cell recordings in…

Cardiac mitochondria and reactive oxygen species generation.

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the…

Tags: 2014, Animals, Cardiac/*metabolism, Cardiovascular Diseases/*metabolism, Chen Yeong-Renn, Circulation research, Department of Integrative Medical Sciences, electron transport chain complex proteins, Heart/*metabolism, Humans, Membrane Potentials/physiology, Mitochondria, myocardial infarction, Myocytes, NEOMED College of Medicine, reactive oxygen species, Reactive Oxygen Species/*metabolism, Signal Transduction/physiology, Zweier Jay L

VDCCs and NMDARs underlie two forms of LTP in CA1 hippocampus in vivo.

N-methyl-D-aspartate receptor/channel (NMDAR) and voltage-dependent calcium channel (VDCC) antagonists applied independently reduce the magnitude of long-term potentiation (LTP) in area CA1 of the hippocampal slice preparation. When used in…

Tags: 1999, Animals, Calcium Channel Blockers/*pharmacology, Dizocilpine Maleate/pharmacology, Excitatory Amino Acid Antagonists/*pharmacology, Excitatory Postsynaptic Potentials/drug effects, Hippocampus/*drug effects, Journal of neurophysiology, Long-Evans, Long-Term Potentiation/*drug effects, Male, Membrane Potentials/physiology, Morgan S L, N-Methyl-D-Aspartate/*antagonists & inhibitors, Rats, Receptors, Teyler T J, Verapamil/pharmacology

Role of HCO3- ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus.

1. Activation of GABAA receptors can produce both hyperpolarizing and depolarizing responses in CA1 pyramidal cells. The hyperpolarizing response is mediated by a Cl- conductance, but the ionic basis of the depolarizing response is not clear. We…

Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.

Certain retroviruses induce progressive spongiform motor neuron disease with features resembling prion diseases and amyotrophic lateral sclerosis. With the neurovirulent murine leukemia virus (MLV) FrCasE, Env protein expression within glia leads to…

Tags: 2014, Action Potentials/physiology, Animals, Antigens/metabolism, auditory midbrain, Calcium/metabolism, Davey Robert A, Department of Integrative Medical Sciences, env/metabolism, Experimental/physiopathology, Gene Products, Hearing Loss/physiopathology, Inferior Colliculi/physiopathology/virology, inferior colliculus, Journal of neurophysiology, Leukemia, Leukemia Virus, Li Ying, Lynch William P, Membrane Potentials/physiology, Mice, Microglia/physiology/virology, Murine/*physiology, NEOMED College of Medicine, Neural Pathways/physiopathology, Neurodegenerative Diseases/*physiopathology, Neuroglia/physiology/virology, Neurons/*physiology/virology, Patch-Clamp Techniques, postinhibitory rebound neurons, Proteoglycans/metabolism, Retroviridae Infections/*physiopathology/virology, retrovirus, Sivaramakrishnan Shobhana, Tissue Culture Techniques, Tumor Virus Infections/*physiopathology/virology, Voltage-Sensitive Dye Imaging, voltage-sensitive dyes

Presynaptic mechanism for heterosynaptic, posttetanic depression in area CA1 of rat hippocampus.

Conditioning stimulation applied to afferent fibers in stratum radiatum or stratum oriens of hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of excitatory postsynaptic potentials (EPSPs). PTD amounted to a

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