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Text
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URL Address
<a href="http://doi.org/10.1016/j.brainres.2004.09.043" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2004.09.043</a>
Pages
186–194
Issue
2
Volume
1029
Dublin Core
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Title
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Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice.
Publisher
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Brain research
Date
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2004
2004-12
Subject
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Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine Agents/*pharmacology; Dopamine Plasma Membrane Transport Proteins; Dopamine/*metabolism; Drug Synergism; Estrogen Antagonists/*pharmacology; Inbred Strains; Male; Membrane Glycoproteins/metabolism; Membrane Transport Proteins/metabolism; Methamphetamine/*pharmacology; Mice; Nerve Tissue Proteins/metabolism; Tamoxifen/*pharmacology
Creator
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Willett Matthew C; Dluzen Dean E
Description
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The antiestrogen, tamoxifen (TMX), has been shown to function as a neuroprotectant against the nigrostriatal dopaminergic (NSDA) neurotoxin, methamphetamine (MA), within male mice. In the present report, we examined the effects of a combined infusion of TMX and MA within superfused striatal tissue fragments of male mice as an approach to understand some of the bases for TMX to function as a NSDA neuroprotectant within male mice. In Experiment 1, a coinfusion of TMX at 1, 10, or 100 pg/ml were all equally effective in increasing
Identifier
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<a href="http://doi.org/10.1016/j.brainres.2004.09.043" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2004.09.043</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animals
Brain research
Corpus Striatum/*drug effects/*metabolism
Dluzen Dean E
Dopamine Agents/*pharmacology
Dopamine Plasma Membrane Transport Proteins
Dopamine/*metabolism
Drug Synergism
Estrogen Antagonists/*pharmacology
Inbred Strains
Male
Membrane Glycoproteins/metabolism
Membrane Transport Proteins/metabolism
Methamphetamine/*pharmacology
Mice
Nerve Tissue Proteins/metabolism
Tamoxifen/*pharmacology
Willett Matthew C