1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0202-13.2013</a> Pages 15964–15977 Issue 40 Volume 33 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons. Publisher An entity responsible for making the resource available The Journal of neuroscience : the official journal of the Society for Neuroscience Date A point or period of time associated with an event in the lifecycle of the resource 2013 2013-10 Subject The topic of the resource Animals; Chick Embryo; Synaptic Transmission/drug effects/*physiology; Excitatory Amino Acid Antagonists/pharmacology; Amino Acids/pharmacology; Cochlear Nucleus/drug effects/metabolism; Cyclopropanes/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; GABAergic Neurons/drug effects/*metabolism; Glycine/analogs & derivatives/pharmacology; Inhibitory Postsynaptic Potentials/drug effects/physiology; Long-Term Synaptic Depression/drug effects/*physiology; Neural Inhibition/drug effects/physiology; Synapses/drug effects/*metabolism; Xanthenes/pharmacology; Receptors; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism Creator An entity primarily responsible for making the resource Tang Zheng-Quan; Liu Yu-Wei; Shi Wei; Dinh Emilie Hoang; Hamlet William R; Curry Rebecca J; Lu Yong Description An account of the resource Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory synapses. Here we report that pharmacological or synaptic activation of group II mGluRs (mGluR II) induces LTD at GABAergic synapses without affecting the excitatory glutamatergic transmission in neurons of the chicken cochlear nucleus. Coefficient of variation and failure rate analysis suggested that the LTD was expressed presynaptically. The LTD requires presynaptic spike activity, but does not require the activation of NMDA receptors. The classic cAMP-dependent protein kinase A signaling is involved in the transduction pathway. Remarkably, blocking mGluR II increased spontaneous GABA release, indicating the presence of tonic activation of mGluR II by ambient glutamate. Furthermore, synaptically released glutamate induced by electrical stimulations that concurrently activated both the glutamatergic and GABAergic pathways resulted in significant and constant suppression of GABA release at various stimulus frequencies (3.3, 100, and 300 Hz). Strikingly, low-frequency stimulation (1 Hz, 15 min) of the glutamatergic synapses induced heterosynaptic LTD of GABAergic transmission, and the LTD was blocked by mGluR II antagonist, indicating that synaptic activation of mGluR II induced the LTD. This novel form of long-term plasticity in the avian auditory brainstem may play a role in the development as well as in temporal processing in the sound localization circuit. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0202-13.2013</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2013 Amino Acids/pharmacology Animals Chick Embryo Cochlear Nucleus/drug effects/metabolism Curry Rebecca J Cyclopropanes/pharmacology Department of Anatomy & Neurobiology Dinh Emilie Hoang Excitatory Amino Acid Agonists/pharmacology Excitatory Amino Acid Antagonists/pharmacology Excitatory Postsynaptic Potentials/drug effects/physiology GABAergic Neurons/drug effects/*metabolism Glycine/analogs & derivatives/pharmacology Hamlet William R Inhibitory Postsynaptic Potentials/drug effects/physiology Liu Yu-Wei Long-Term Synaptic Depression/drug effects/*physiology Lu Yong Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism NEOMED College of Medicine Neural Inhibition/drug effects/physiology Receptors Shi Wei Synapses/drug effects/*metabolism Synaptic Transmission/drug effects/*physiology Tang Zheng-Quan The Journal of neuroscience : the official journal of the Society for Neuroscience Xanthenes/pharmacology