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Text
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URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0202-13.2013</a>
Pages
15964–15977
Issue
40
Volume
33
Dublin Core
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Title
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Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.
Publisher
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The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
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2013
2013-10
Subject
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Animals; Chick Embryo; Synaptic Transmission/drug effects/*physiology; Excitatory Amino Acid Antagonists/pharmacology; Amino Acids/pharmacology; Cochlear Nucleus/drug effects/metabolism; Cyclopropanes/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; GABAergic Neurons/drug effects/*metabolism; Glycine/analogs & derivatives/pharmacology; Inhibitory Postsynaptic Potentials/drug effects/physiology; Long-Term Synaptic Depression/drug effects/*physiology; Neural Inhibition/drug effects/physiology; Synapses/drug effects/*metabolism; Xanthenes/pharmacology; Receptors; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
Creator
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Tang Zheng-Quan; Liu Yu-Wei; Shi Wei; Dinh Emilie Hoang; Hamlet William R; Curry Rebecca J; Lu Yong
Description
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Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory synapses. Here we report that pharmacological or synaptic activation of group II mGluRs (mGluR II) induces LTD at GABAergic synapses without affecting the excitatory glutamatergic transmission in neurons of the chicken cochlear nucleus. Coefficient of variation and failure rate analysis suggested that the LTD was expressed presynaptically. The LTD requires presynaptic spike activity, but does not require the activation of NMDA receptors. The classic cAMP-dependent protein kinase A signaling is involved in the transduction pathway. Remarkably, blocking mGluR II increased spontaneous GABA release, indicating the presence of tonic activation of mGluR II by ambient glutamate. Furthermore, synaptically released glutamate induced by electrical stimulations that concurrently activated both the glutamatergic and GABAergic pathways resulted in significant and constant suppression of GABA release at various stimulus frequencies (3.3, 100, and 300 Hz). Strikingly, low-frequency stimulation (1 Hz, 15 min) of the glutamatergic synapses induced heterosynaptic LTD of GABAergic transmission, and the LTD was blocked by mGluR II antagonist, indicating that synaptic activation of mGluR II induced the LTD. This novel form of long-term plasticity in the avian auditory brainstem may play a role in the development as well as in temporal processing in the sound localization circuit.
Identifier
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<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0202-13.2013</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Amino Acids/pharmacology
Animals
Chick Embryo
Cochlear Nucleus/drug effects/metabolism
Curry Rebecca J
Cyclopropanes/pharmacology
Department of Anatomy & Neurobiology
Dinh Emilie Hoang
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
GABAergic Neurons/drug effects/*metabolism
Glycine/analogs & derivatives/pharmacology
Hamlet William R
Inhibitory Postsynaptic Potentials/drug effects/physiology
Liu Yu-Wei
Long-Term Synaptic Depression/drug effects/*physiology
Lu Yong
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
NEOMED College of Medicine
Neural Inhibition/drug effects/physiology
Receptors
Shi Wei
Synapses/drug effects/*metabolism
Synaptic Transmission/drug effects/*physiology
Tang Zheng-Quan
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xanthenes/pharmacology