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Text
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<a href="http://doi.org/10.1111/j.1365-2826.2007.01581.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1365-2826.2007.01581.x</a>
Pages
725–731
Issue
9
Volume
19
Dublin Core
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Title
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Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice.
Publisher
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Journal of neuroendocrinology
Date
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2007
2007-09
Subject
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Adrenergic Uptake Inhibitors/*metabolism; Animals; Corpus Striatum/anatomy & histology/*metabolism; Dopamine Agents/metabolism; Dopamine/*metabolism; Female; Male; Methamphetamine/metabolism; Mice; Potassium/*metabolism; Reserpine/*metabolism; Sex Factors; Tissue Culture Techniques; Vesicular Monoamine Transport Proteins/metabolism
Creator
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Ji J; McDermott J L; Dluzen D E
Description
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Reserpine inhibits vesicular monoamine transporter-2 (VMAT-2) function and thereby impairs vesicular dopamine (DA) storage within nerve terminals. The present report compared the effects of reserpine treatment upon the striatal dopaminergic system in male and female mice as a means to assess potential sex differences in VMAT-2/DA storage function. After treatment with reserpine, male mice showed significantly greater striatal DA concentrations and K+ -evoked DA output from the striatum compared to females. By contrast, no statistically significant sex differences were observed in methamphetamine-evoked DA output in reserpine-treated mice. These results demonstrate a clear sex difference in the striatal dopaminergic responses to reserpine and suggest that females possess a more active VMAT-2/DA storage capacity, as indicated by the greater degree of deficits observed when VMAT-2/DA storage function is inhibited by reserpine. Such findings have important implications for understanding some of the bases for sex differences in neurotoxicity and neurodegeneration of the nigrostriatal dopaminergic system.
Identifier
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<a href="http://doi.org/10.1111/j.1365-2826.2007.01581.x" target="_blank" rel="noreferrer noopener">10.1111/j.1365-2826.2007.01581.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Adrenergic Uptake Inhibitors/*metabolism
Animals
Corpus Striatum/anatomy & histology/*metabolism
Dluzen D E
Dopamine Agents/metabolism
Dopamine/*metabolism
Female
Ji J
Journal of neuroendocrinology
Male
McDermott J L
Methamphetamine/metabolism
Mice
Potassium/*metabolism
Reserpine/*metabolism
Sex Factors
Tissue Culture Techniques
Vesicular Monoamine Transport Proteins/metabolism