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Text
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URL Address
<a href="http://doi.org/10.1534/genetics.116.193805" target="_blank" rel="noreferrer noopener">http://doi.org/10.1534/genetics.116.193805</a>
Pages
1559–1572
Issue
4
Volume
204
Dublin Core
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Title
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Genetics of Skeletal Evolution in Unusually Large Mice from Gough Island.
Publisher
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Genetics
Date
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2016
2016-12
Subject
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Female; Male; Animals; *body size; *complex trait; *island syndrome; *phenotypic extreme; *pleiotropy; *Quantitative Trait Loci; *skeletal evolution; Body Size/*genetics; Bone and Bones/*anatomy & histology; Genetic Pleiotropy; Islands; Mice/*genetics; Molecular; *Evolution
Creator
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Parmenter Michelle D; Gray Melissa M; Hogan Caley A; Ford Irene N; Broman Karl W; Vinyard Christopher J; Payseur Bret A
Description
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Organisms on islands often undergo rapid morphological evolution, providing a platform for understanding mechanisms of phenotypic change. Many examples of evolution on islands involve the vertebrate skeleton. Although the genetic basis of skeletal variation has been studied in laboratory strains, especially in the house mouse Mus musculus domesticus, the genetic determinants of skeletal evolution in natural populations remain poorly understood. We used house mice living on the remote Gough Island-the largest wild house mice on record-to understand the genetics of rapid skeletal evolution in nature. Compared to a mainland reference strain from the same subspecies (WSB/EiJ), the skeleton of Gough Island mice is considerably larger, with notable expansions of the pelvis and limbs. The Gough Island mouse skeleton also displays changes in shape, including elongations of the skull and the proximal vs. distal elements in the limbs. Quantitative trait locus (QTL) mapping in a large F2 intercross between Gough Island mice and WSB/EiJ reveals hundreds of QTL that control skeletal dimensions measured at 5, 10, and/or 16 weeks of age. QTL exhibit modest, mostly additive effects, and Gough Island alleles are associated with larger skeletal size at most QTL. The QTL with the largest effects are found on a few chromosomes and affect suites of skeletal traits. Many of these loci also colocalize with QTL for body weight. The high degree of QTL colocalization is consistent with an important contribution of pleiotropy to skeletal evolution. Our results provide a rare portrait of the genetic basis of skeletal evolution in an island population and position the Gough Island mouse as a model system for understanding mechanisms of rapid evolution in nature.
Identifier
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<a href="http://doi.org/10.1534/genetics.116.193805" target="_blank" rel="noreferrer noopener">10.1534/genetics.116.193805</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*body size
*complex trait
*Evolution
*island syndrome
*phenotypic extreme
*pleiotropy
*Quantitative Trait Loci
*skeletal evolution
2016
Animals
Body Size/*genetics
Bone and Bones/*anatomy & histology
Broman Karl W
Female
Ford Irene N
Genetic Pleiotropy
Genetics
Gray Melissa M
Hogan Caley A
Islands
Male
Mice/*genetics
Molecular
Parmenter Michelle D
Payseur Bret A
Vinyard Christopher J