Browse Items (315 total)
- Tags: Mice
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.
Tags: *gp91(phox), *Microglia, *MPTP, *Na(v)1.6, *Neuroinflammation, *Parkinson's disease, *TNF-alpha, *Voltage-gated sodium channels, *Zonisamide, 2018, Aged, Animals, Antiparkinson Agents/*pharmacology, Experimental neurology, Female, Gearing Marla, Hossain Muhammad M, Humans, Inbred C57BL, Inflammation/metabolism, Male, Mice, Microglia/drug effects/*metabolism, NAV1.6 Voltage-Gated Sodium Channel/*biosynthesis, Neuroprotective Agents/pharmacology, Parkinsonian Disorders/*metabolism/pathology, Reuhl Kenneth, Richardson Jason R, Weig Blair, Wu Long-Jun, Zonisamide/*pharmacology
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.
Tags: *Signal Transduction, 2018, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*antagonists & inhibitors/pharmacology, Department of Integrative Medical Sciences, Disease Models, Ferrell Jessica M, G-Protein-Coupled/*metabolism, Gastrointestinal Microbiome/*drug effects, Glucagon-Like Peptide 1/metabolism, Gonzalez Frank J, GTP-Binding Proteins/*metabolism, Hepatology (Baltimore, Md.), Inbred C57BL, Krausz Kristopher W, Lipid Metabolism, Male, Mice, NEOMED College of Medicine, Nichols Robert G, Pathak Preeti, Patterson Andrew D, Random Allocation, Receptors, Sensitivity and Specificity, Xie Cen
Propofol restores transient receptor potential vanilloid receptor subtype-1 sensitivity via activation of transient receptor potential ankyrin receptor subtype-1 in sensory neurons.
Tags: 2011, Anesthesiology, Anesthetics, Animal Studies, Bratz Ian N, Bratz IN, Capsaicin, Carrier Proteins – Drug Effects, Carrier Proteins – Metabolism, Cells, Damron Derek S, Damron DS, Genes – Drug Effects, Intravenous – Pharmacodynamics, Male, Mice, Propofol – Pharmacodynamics, Sensory Receptor Cells – Drug Effects, Sinha S, Sinha Sayantani, Wickley Peter J, Wickley PJ, Zhang H, Zhang Hongyu
Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction.
Tags: 2012, Agarwal U, Animal Studies, Apoptosis – Physiology, Cardiovascular System Physiology, Cell Movement – Physiology, Cell Physiology, Cell Surface, Cell Surface – Metabolism, Cells, Circulation, Coronary Circulation – Physiology, Cytokines – Metabolism, Department of Integrative Medical Sciences, Dong F, Finan A, Gene Expression – Physiology, Harvey J, Mice, myocardial infarction, Myocardial Infarction – Pathology, Myocardial Infarction – Therapy, Myocardium, NEOMED College of Medicine, Penn M S, Proteins, Receptors, Stem Cells – Metabolism, Stem Cells – Transplantation, Weber K
Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload.
Tags: 2014, Animal Studies, Aorta – Physiopathology, Blotting, Descriptive Statistics, Echocardiography, Evidence-based Complementary & Alternative Medicine (eCAM), Funding Source, Gene Expression Profiling, Gong Kaizheng, Guo Liheng, Heart Diseases – Prevention and Control, Hypertrophy – Prevention and Control, In Vivo Studies, Liu Qin, Mice, One-Way Analysis of Variance, Phosphorylation – Drug Effects, Plant Extracts – Therapeutic Use, Post Hoc Analysis, Protein Kinases – Antagonists and Inhibitors, Qi Jianyong, Signal Transduction, Staining and Labeling, T-Tests, Vasoconstriction, Wang Lei, Western, Wu Jiashin, Yu Juan, Zhang Minzhou, Zhou Miao
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.
Tags: 1999, Animals, Base Sequence, Blotting, Cell Line, Chiang J Y, Chromosome Mapping, Cloning, Codon, Complementary/biosynthesis/*isolation & purification, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA, Genetic, Genetic/genetics, Humans, Hydroxycholesterols/metabolism, Initiator, Javitt N B, Journal of lipid research, Luciferases/genetics, Martin K O, Mice, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Northern, Nucleic Acid, Promoter Regions, Regulatory Sequences, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Wu Z
Natural cytotoxins in human plasma: isolation and characterization of phospholipids associated with cytotoxic lipoproteins.
Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration.
Tags: *Gene Transfer Techniques, *Genes, *Microglia/cytology, *Stem Cells/cytology, 1999, Animals, Cell Line, env, Hematopoietic Stem Cell Transplantation, Journal of virology, Lynch W P, Mice, Nerve Degeneration, Retroviridae Infections/pathology/*virology, Retroviridae/genetics/*physiology, Sharpe A H, Snyder E Y
Monoamine-activated alpha 2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction.
Tags: 1994, Adrenal Gland Neoplasms, alpha-Macroglobulins/isolation & purification/*metabolism/pharmacology, Animals, ErbB Receptors/isolation & purification/metabolism, Fibrinolysin/metabolism, Humans, Koo P H, Male, Mice, Mitogen-Activated Protein Kinase 1, Nerve Growth Factor/drug effects/isolation & purification/*metabolism, Nerve Growth Factors/*pharmacology, Neurites/drug effects/*physiology, PC12 Cells, Pheochromocytoma, Phosphorylation, Platelet-Derived Growth Factor/isolation & purification/metabolism, Protein-Serine-Threonine Kinases/metabolism, Protein-Tyrosine Kinases/metabolism, Proto-Oncogene Proteins/drug effects/isolation & purification/*metabolism, Qiu W S, Receptor, Receptor Protein-Tyrosine Kinases/drug effects/isolation & purification/*metabolism, Receptors, Serotonin/*metabolism/pharmacology, Signal Transduction/drug effects/*physiology, The Journal of biological chemistry, trkA
Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin.
Tags: *Mitogen-Activated Protein Kinases, 1998, 3T3 Cells/chemistry/cytology/enzymology, alpha-Macroglobulins/*pharmacology, Animals, Antineoplastic Agents/pharmacology, Brain-Derived Neurotrophic Factor/pharmacology, Calcium-Calmodulin-Dependent Protein Kinases/metabolism, Cell Differentiation/drug effects, Ciliary Neurotrophic Factor, Cultured/chemistry/cytology/enzymology, Hu Y Q, Humans, Isoenzymes/metabolism, Journal of neurochemistry, Koo P H, Mice, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3, Nerve Growth Factor/*metabolism, Nerve Growth Factors/pharmacology, Neuroblastoma, Neuroprotective Agents/*metabolism, Neurotrophin 3, Phospholipase C gamma, Phosphorylation, Receptor, Receptor Protein-Tyrosine Kinases/*metabolism, Receptors, Serotonin/metabolism, Signal Transduction/drug effects/*physiology, Tretinoin/pharmacology, trkC, Tumor Cells, Type C Phospholipases/metabolism
Antitumor effect of novel silatranes on renal cell carcinoma in mice.
Tags: *Bridged Bicyclo Compounds, *Organosilicon Compounds, 1992, Animals, Anticancer research, Antineoplastic Agents/pharmacology/*therapeutic use, Bridged Bicyclo Compounds/pharmacology/*therapeutic use, Carcinoma, Female, Grna A, Heterocyclic, Hogan J, Inbred BALB C, Kidney Neoplasms/*drug therapy, Koo P H, Mice, Renal Cell/*drug therapy, Silicon/pharmacology/*therapeutic use, Structure-Activity Relationship
Modulatory effects of testosterone on
Tags: *MPTP Poisoning, 1-Methyl-4-phenyl-1, 1994, 2, 3, 6-tetrahydropyridine/antagonists & inhibitors, Animals, Corpus Striatum/drug effects/*metabolism, Dluzen D, Dopamine/*metabolism, Drug Implants, Inbred C57BL, Inbred Strains, Jain R, Journal of neurochemistry, Levodopa/pharmacology, Liu B, Male, Mice, Neurotoxins/antagonists & inhibitors/*toxicity, Orchiectomy, Parkinson Disease, Reference Values, Secondary/chemically induced/*physiopathology, Species Specificity, Testosterone/administration & dosage/*pharmacology
Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.
Tags: 2002, Anderson Linda I, Animals, Body Temperature/drug effects, Body Weight/drug effects, Corpus Striatum/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Drug Interactions, Estrogens/pharmacology/*physiology, Female, Heart Rate/drug effects, Heart Ventricles/metabolism, Inbred Strains, Male, Methamphetamine/*toxicity, Mice, Neurotoxicology and teratology, Norepinephrine/metabolism, Orchiectomy, Organ Size/drug effects, Ovariectomy, Pilati Charles F, Pituitary Gland/anatomy & histology, Sex Factors, Testosterone/pharmacology/*physiology
The effects of intranasal infusion of
Tags: 1-Methyl-4-phenyl-1, 1996, 2, 3, 6-tetrahydropyridine/administration & dosage/*pharmacology, Administration, Animals, Brain research, Catecholamines/*metabolism, Corpus Striatum/drug effects/*metabolism, Department of Internal Medicine, Dluzen D E, Dopamine Agents/administration & dosage/*pharmacology, Dopamine/metabolism, Inbred C57BL, Injections, Intranasal, Intraperitoneal, Kefalas G, Male, Mice, NEOMED College of Medicine, Norepinephrine/metabolism, Olfactory Bulb/drug effects/*metabolism
Intrastrain variants of herpes simplex virus type 1 isolated from a neonate with fatal disseminated infection differ in the ICP34.5 gene, glycoprotein processing, and neuroinvasiveness.
Tags: *Genetic Variation, *Protein Processing, 1999, Amino Acid, Amino Acid Sequence, Animal, Animals, Base Sequence, Bower J R, Deoxyribonuclease BamHI, Deoxyribonuclease EcoRI, Detwiler M, Disease Models, DNA, Durishin C, Genes, Glycoproteins/metabolism, Herpesvirus 1, Human/*genetics/growth & development/isolation & purification, Humans, Inbred BALB C, Journal of virology, Karban T L, Male, Mao H, Mice, Molecular Sequence Data, Nucleic Acid, Polymerase Chain Reaction/methods, Polymorphism, Post-Translational, Rempinski D, Restriction Fragment Length, Rosenthal K S, Rozenbom E, Sequence Analysis, Sequence Homology, Viral, Viral Envelope Proteins/analysis, Viral Proteins/*genetics
Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction.
Tags: *Disease Models, 2014, Animal, Animal Studies, Animals, Antioxidants – Administration and Dosage, Antioxidants – Metabolism, Antioxidants – Pharmacokinetics, Antioxidants – Therapeutic Use, Antioxidants/administration & dosage/*metabolism/pharmacokinetics/therapeutic use, Apolipoprotein A-I/blood/genetics/*metabolism, Apolipoproteins, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Biological, Cardiotonic Agents – Administration and Dosage, Cardiotonic Agents – Metabolism, Cardiotonic Agents – Pharmacokinetics, Cardiotonic Agents – Therapeutic Use, Cardiotonic Agents/administration & dosage/metabolism/pharmacokinetics/therapeutic use, Coenzyme Q, Coenzyme Q – Administration and Dosage, Coenzyme Q – Metabolism, Coenzyme Q – Pharmacokinetics, Coenzyme Q – Therapeutic Use, Dadabayev Alisher R, Dietary Supplements, Electron Transport – Drug Effects, Electron Transport Complex II/chemistry/metabolism, Electron Transport Complex III/chemistry/metabolism, Electron Transport/drug effects, Heart – Drug Effects, Heart/drug effects, Heart/drug effects/enzymology/*metabolism, Hypoalphalipoproteinemias/physiopathology, Inborn Errors – Physiopathology, Injections, Intestinal Absorption, Intraperitoneal, Knockout, Latchoumycandane Calivarathan, Lesnefsky Edward J, Lipid Metabolism, Male, McIntyre Thomas M, Mice, Mitochondria, Mitochondria – Drug Effects, Mitochondria – Metabolism, Models, Myocardial Infarction – Etiology, Myocardial Infarction – Metabolism, Myocardial Infarction – Pathology, Myocardial Infarction – Therapy, Myocardial Infarction/etiology/metabolism/pathology/*therapy, Myocardial Reperfusion Injury – Blood, Myocardial Reperfusion Injury – Metabolism, Myocardial Reperfusion Injury – Pathology, Myocardial Reperfusion Injury – Prevention and Control, Myocardial Reperfusion Injury/blood/metabolism/pathology/prevention & control, Myocardium, Myocardium – Metabolism, Myocardium – Pathology, Myocardium/enzymology/*metabolism/pathology, Penn Marc S, Proteins, Proteins – Metabolism, The Journal of nutrition, Tissue Distribution, Ubiquinone/administration & dosage/*analogs & derivatives/metabolism/pharmacokinetics/therapeutic use, Yin Guotian
High concentrations of divalent cations isolate monosynaptic inputs from local circuits in the auditory midbrain.
Tags: 2013, Acoustic Stimulation, Animals, Cations, Divalent/*pharmacology, first spike latency, Frontiers in neural circuits, Grimsley Calum Alex, high divalents, Inferior Colliculi/drug effects/*physiology, inferior colliculus, local circuits, Mice, monosynaptic, Neural Inhibition/drug effects/*physiology, Reaction Time/drug effects/physiology, Sanchez Jason Tait, Sivaramakrishnan Shobhana, Synapses/drug effects/*physiology
Midbrain local circuits shape sound intensity codes.
Tags: 2013, Acoustic Stimulation, Animals, Auditory Pathways/*physiology, Auditory Perception/*physiology, Auditory Threshold/physiology, Frontiers in neural circuits, Grimsley Calum Alex, high divalents, Inferior Colliculi/*physiology, inferior colliculus, local circuits, Mice, monosynaptic, Neural Inhibition/*physiology, Neurons/physiology, Sanchez Jason Tait, Sivaramakrishnan Shobhana, sound intensity
Functional architecture of the inferior colliculus revealed with voltage-sensitive dyes.
Tags: 2013, Acoustic Stimulation/methods, Animals, Auditory Pathways/chemistry/cytology/physiology, Chandrasekaran Lakshmi, Fluorescent Dyes/*analysis, Frontiers in neural circuits, Inbred CBA, Inferior Colliculi/*chemistry/*cytology/physiology, laminar organization, local circuits, Long-Evans, Mice, microcircuits, Nerve Net/*chemistry/*cytology/physiology, population coding, post-inhibitory rebound, Rats, Sivaramakrishnan Shobhana, Voltage-Sensitive Dye Imaging/*methods, Xiao Ying
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N
Gelucire-stabilized nanoparticles as a potential DNA delivery system.
Tags: *Gene Transfer Techniques, 2016, Animals, Cationic lipids, Cell Line, Cell Survival/drug effects/physiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, DNA/*administration & dosage/chemistry, gene therapy, Hep G2 Cells, Humans, macrophage activation, Macrophages/drug effects/physiology, Mice, Nanoparticles, Nanoparticles/*administration & dosage/chemistry, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Oyewumi Moses O, Pharmaceutical development and technology, Polyethylene Glycols/*administration & dosage/chemistry, Sadana Prabodh, Transfection, Wehrung Daniel
Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.
Tags: *Drug Delivery Systems, 2011, Adenosine Triphosphatases/metabolism, Animals, Antineoplastic Agents, ATP Binding Cassette Transporter, Blood-Brain Barrier/metabolism, Brain Neoplasms/drug therapy, Bui Thong, Cell Death/drug effects, Cell Line, Coumarins/administration & dosage/pharmacokinetics, Delayed-Action Preparations, Geldenhuys Werner, Glioma/drug therapy/pathology, Glutathione/*chemistry, Harrison Kimberly, Humans, Inbred C57BL, Journal of drug targeting, Male, Mbimba Thomas, Member 1/metabolism, Mice, Microtubules/metabolism, Nanoparticles, Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology, Particle Size, Permeability, Phytogenic/administration & dosage/*pharmacokinetics/pharmacology, Rats, Subfamily B, Sutariya Vijaykumar, Thiazoles/administration & dosage/pharmacokinetics, Tubulin/metabolism, Tumor
Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.
Tags: 2011, Ahmed Shamima, Animals, Anticarcinogenic Agents/chemistry/*therapeutic use, Antineoplastic Agents, Bishayee Anupam, Brankov Nikoleta, Breast Neoplasms/*drug therapy/*prevention & control, Chemoprevention, Frontiers in bioscience (Landmark edition), Glycosides/therapeutic use, Humans, Mice, Oleanolic Acid/analogs & derivatives/therapeutic use, Perloff Marjorie, Phytogenic/therapeutic use, Triterpenes/*therapeutic use
Ligand epitope antigen presentation system vaccines against herpes simplex virus.
Tags: *Antigen Presentation, *Cancer Vaccines, *Epitopes, 2005, Animals, Frontiers in bioscience : a journal and virtual library, Glycoproteins/chemistry, Goel Neena, Herpesvirus 1, Human/metabolism, Humans, Immediate-Early Proteins/chemistry, Ligands, Mice, Rosenthal Kenneth S, Simplexvirus/*metabolism, Zimmerman Daniel H
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.
Tags: 2017, ADME, Animals, Antineoplastic Agents/*therapeutic use, Apoptosis, Brain cancer, Brain Neoplasms/*drug therapy/pathology/*secondary, Breast Neoplasms/*pathology, Cell Line, Chemotherapy, CNS, Current cancer drug targets, Department of Anatomy & Neurobiology, distribution, Drug Discovery, Drug Resistance, Female, Geldenhuys Werner J, Griffith Jessica I G, Humans, Lockman Paul R, Mice, NEOMED College of Medicine, Safadi Fayez F, Sondag Gregory R, Terell-Hall Tori B, Tumor, Venishetty Vinay K
TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.
Tags: 2016, Adapala Ravi K, Animals, Cappelli Holly C, Carcinoma, Cell Movement/physiology, Department of Integrative Medical Sciences, endothelial cell, Endothelial Cells/metabolism/pathology, Inbred C57BL, Kanugula Anantha K, Knockout, Lewis Lung/metabolism/*pathology, Mechanotransduction, Mice, NEOMED College of Medicine, Neovascularization, Oncotarget, Paruchuri Sailaja, Pathologic/*metabolism/pathology, rho-Associated Kinases/*metabolism, Rho/Rho kinase, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/*metabolism, TRPV4, tumor angiogenesis
Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells.
Tags: *Cell Movement, *Cell Proliferation, 2016, Animals, Apoptosis, Biomarkers, Carcinoma, Cell Adhesion, Cultured, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Female, GPNMB, Humans, integrin, Lung cancer, Lung Neoplasms/metabolism/*pathology, Manickavasagam Dharani, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, NEOMED College of Pharmacy, Neoplasm Invasiveness, Non-Small-Cell Lung/metabolism/*pathology, Novak Kimberly, NSCLC, Nude, Oncotarget, Oyewumi Moses O, Paulic Nikola, Protein Domains, Safadi Fayez F, Sondag Gregory R, Tumor Cells, Tumor/*metabolism, Wehrung Daniel, Xenograft Model Antitumor Assays
Coding the meaning of sounds: contextual modulation of auditory responses in the basolateral amygdala.
Tags: 2013, Acoustic Stimulation/*methods, Action Potentials/*physiology, Amygdala/*physiology, Animal/*physiology, Animals, Auditory Perception/*physiology, Cats, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Female, Grimsley Jasmine M S, Hazlett Emily G, Inbred CBA, Male, Mice, NEOMED College of Medicine, The Journal of neuroscience : the official journal of the Society for Neuroscience, Vocalization, Wenstrup Jeffrey J
TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.
Tags: 13-dienoic Acid/*antagonists & inhibitors/pharmacology, 15-Hydroxy-11 alpha, 2017, 9 alpha-(epoxymethano)prosta-5, Andrei Spencer R, Animals, Bratz Ian N, Cells, Coronary Vessels/*drug effects/metabolism, Cultured, Damron Derek S, Endothelial Cells/drug effects/metabolism, Inbred C57BL, Knockout, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism, Male, Mice, Microvessels/drug effects/metabolism, Nitric Oxide Synthase Type III/metabolism, PloS one, Propofol/*pharmacology, Showalter Loral E, Sinha Sayantani, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*metabolism, TRPA1 Cation Channel, TRPV Cation Channels/genetics/*metabolism, Vasoconstrictor Agents/antagonists & inhibitors/pharmacology, Vasodilation/drug effects/physiology, Vasodilator Agents/*pharmacology
Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.
Tags: 2016, Animal, Animals, Aorta, Benzofurans/chemistry/*pharmacology, Blood Pressure/drug effects, Brain/blood, Cardiac/cytology/drug effects/metabolism, Cell Line, Chen Renshan, Chinese Herbal/chemistry/pharmacology, Disease Models, Drugs, GATA4 Transcription Factor/metabolism, Gu Weiwang, Heart Failure/metabolism/*pathology, Heart Ventricles/diagnostic imaging, Inbred C57BL, Male, Mice, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Myocardium/metabolism/pathology, Myocytes, Natriuretic Peptide, Phosphorylation/drug effects, PloS one, Proto-Oncogene Proteins c-akt/metabolism, Qi Jianyong, Rats, Signal Transduction/*drug effects, Tan Yafang, Thoracic/surgery, Wu Jiashin, Yu Juan, Zhang Minzhou
Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channels.
Tags: 2015, Animals, Arterial Pressure/drug effects, Bratz Ian N, Damron Derek S, Drug Evaluation, Female, Inbred C57BL, Knockout, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*physiology, Male, Mice, Nitric Oxide/*physiology, PloS one, Preclinical, Propofol/*pharmacology, Signal Transduction, Sinha Sayantani, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*metabolism, TRPA1 Cation Channel, TRPV Cation Channels/genetics/metabolism, Vasodilator Agents/*pharmacology
Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation.
Tags: *Cell Differentiation, 2015, Animals, Barbe Mary F, Cell Adhesion, Cell Line, Connective Tissue Growth Factor/chemistry/*metabolism, Core Binding Factor Alpha 1 Subunit/metabolism, Cytoskeleton/*metabolism, Department of Anatomy & Neurobiology, Extracellular Signal-Regulated MAP Kinases/metabolism, Focal Adhesion Protein-Tyrosine Kinases/metabolism, Hendesi Honey, Integrins/*metabolism, Mice, Monroy M Alexandra, NEOMED College of Medicine, Osteoblasts/*cytology/*metabolism, PloS one, Popoff Steven N, rac GTP-Binding Proteins/metabolism, Receptors, Safadi Fayez F, Signal Transduction, Transcriptional Activation, Vitronectin/metabolism
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.
Tags: *Postprandial Period, 2014, Acetylation/drug effects, Animals, ATP Citrate (pro-S)-Lyase/metabolism, Blood Glucose/*metabolism, Carboxylic Ester Hydrolases/*metabolism, Cheng Gang, Chromatin/metabolism, Department of Integrative Medical Sciences, Enzymologic/drug effects, Gene Expression Regulation, Glucose/*pharmacology, Histones/metabolism, Homeostasis, Inbred C57BL, Li Yuanyuan, Liver/*enzymology, Male, Mice, NEOMED College of Medicine, Nutritional Status, PloS one, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Bone marrow SSEA1+ cells support the myocardium in cardiac pressure overload.
Tags: *Bone Marrow Transplantation, 2013, Animals, Bone Marrow Cells/cytology/*metabolism, Cardiac/cytology/metabolism, Cell Tracking, Department of Integrative Medical Sciences, Dong Feng, Finan Amanda, Kiedrowski Matthew, Lewis X Antigen/*metabolism, Male, Mesenchymal Stem Cells/cytology/metabolism, Mice, Myocardium/cytology/*metabolism/pathology, Myocytes, NEOMED College of Medicine, Penn Marc S, PloS one, Sopko Nikolai, Turturice Ben, Ventricular Remodeling
Development of social vocalizations in mice.
Tags: *Social Behavior, 2011, Acoustics, Aging/physiology, Animal/*physiology, Animals, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Female, Grimsley Jasmine M S, Male, Mice, Monaghan Jessica J M, NEOMED College of Medicine, Newborn, Nonlinear Dynamics, Phonetics, PloS one, Sound Spectrography, Vocal Cords/physiology, Vocalization, Wenstrup Jeffrey J
Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.
Tags: 2017, Abdala Carolina, Animals, Coate Thomas Matthew, Cruz Charlene, Female, Friedman Rick A, Ge Marshall X, Gundimeda Usha, Inbred C57BL, Kelley Matthew William, Knockout, Lael Cantu Homero, Lavinsky Joel, Male, Mice, Michelle Baum Leah, Myint Anthony, Neurogenesis, Neurons/cytology, Neuropilin-1/genetics/*metabolism, Nikolakopoulou Angeliki Maria, Ohyama Takahiro, PLoS genetics, Salehi Pezhman, Semaphorin-3A/genetics/*metabolism, Signal Transduction, Spiral Ganglion/cytology/*embryology, Tao Litao, Wang Juemei
Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Askew Michael J, Biomechanical Phenomena, Body Weight/drug effects, Bone and Bones/drug effects, Bone/prevention & control, Collagen Type I, Collagen/genetics, Densitometry, Department of Family & Community Medicine, Disease Models, Femur/drug effects/pathology, Fractures, Growth Hormone/*therapeutic use, Heterozygote, Humans, Inbred C57BL, Jarjoura David, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, King Donna, Lumbar Vertebrae/drug effects, McEwen Heather A, Mice, Mutation, NEOMED College of Medicine, Osteoblasts/*drug effects/metabolism, Osteogenesis Imperfecta/*drug therapy, Phenotype, Time Factors, Transgenic
Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.
Tags: 2012, Adipose Tissue, Adiposity/genetics, Animals, Brown/pathology, Carcinoma/etiology/*genetics, Cell Transformation, Chen Wei-Dong, Cytoplasmic and Nuclear/*deficiency/genetics, Diet, Dietary Fats/metabolism, Edwards Peter A, Energy Metabolism/genetics, Female, Ge Xuemei, Gene Knockout Techniques, Glucose Intolerance/complications/genetics, Heemstra Lydia A, High-Fat/*adverse effects, Intestinal Absorption, Kasim Neda, Knockout, Leptin/deficiency/genetics, Liver Neoplasms/etiology/*genetics, Liver/pathology, Ma Huiyan, Male, Mice, Molecular endocrinology (Baltimore, Md.), Muscle, Neoplastic/genetics, Novak Colleen M, Obese, Obesity/*etiology/genetics, Receptors, Sex Factors, Skeletal/metabolism, Smith Joseph L, Weight Gain/genetics, Xu Jiesi, Zhang Yanqiao
Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes.
Tags: 2018, Adult, Aged, Animal Studies, Animals, Apolipoprotein A-I/blood/*metabolism, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Bena James, Biochemical Phenomena, Case Control Studies, Case-Control Studies, Cells, Comparative Studies, Cultured, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Dyslipidemias/complications/diet therapy/*metabolism, Evaluation Research, Female, Funding Source, Glycosylation, Golizeh Makan, HDL – Metabolism, HDL/*metabolism, Human, Humans, Hyperglycemia – Complications, Hyperglycemia – Diet Therapy, Hyperglycemia – Metabolism, Hyperglycemia/complications/diet therapy/*metabolism, Hyperlipidemia – Complications, Hyperlipidemia – Diet Therapy, Hyperlipidemia – Metabolism, Ilchenko Serguei, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Lipoproteins, Male, Mice, Middle Age, Middle Aged, Multicenter Studies, NEOMED College of Pharmacy, Osme Abdullah, Previs Stephen F, Protein Stability, Smith Jonathan D, The Journal of clinical endocrinology and metabolism, Type 2 – Complications, Type 2 – Diet Therapy, Type 2 – Metabolism, Type 2/complications/*diet therapy/metabolism, Validation Studies, Wang Shuhui
Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia.
Tags: *Drug Delivery Systems, *Inflammation, *Microglia, *neuroprotection, *polymersomes, *simvastatin, 2017, Animals, Anti-Inflammatory Agents/*pharmacology, Department of Pharmaceutical Sciences, Inbred BALB C, Interleukin-6/antagonists & inhibitors/biosynthesis, Lactates/*administration & dosage, Manickavasagam Dharani, Mice, Microglia/*drug effects, NEOMED College of Pharmacy, Nitric Oxide/antagonists & inhibitors/biosynthesis, Novak Kimberly, Oyewumi Moses O, Polyethylene Glycols/*administration & dosage, Simvastatin/*administration & dosage/pharmacology, The AAPS journal, Tumor Necrosis Factor-alpha/antagonists & inhibitors/biosynthesis