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Text
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<a href="http://doi.org/10.1111/j.1553-2712.2001.tb02111.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1553-2712.2001.tb02111.x</a>
Pages
337–342
Issue
4
Volume
8
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Title
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Intranasal lidocaine for the treatment of migraine headache: a randomized, controlled trial.
Publisher
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Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Date
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2001
2001-04
Subject
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Administration; Adolescent; Adult; Anesthetics; Confidence Intervals; Double-Blind Method; Female; Hospitals; Humans; Intranasal; Lidocaine/*administration & dosage; Local; Male; Middle Aged; Migraine without Aura/diagnosis/*drug therapy; Ohio; Pain Measurement; Patient Satisfaction; Reference Values; Severity of Illness Index; Teaching; Treatment Outcome
Creator
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Blanda M; Rench T; Gerson L W; Weigand J V
Description
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OBJECTIVE: To evaluate the effect of intranasal lidocaine for immediate relief (5 minutes) of migraine headache pain. METHODS: A randomized, double-blind, placebo-controlled clinical trial at two university-affiliated community teaching hospitals enrolled patients 18-50 years old with migraine headache as defined by the International Headache Society. Patients who were pregnant, lactating, known to abuse alcohol or drugs, or allergic to one of the study drugs, those who used analgesics within two hours, or those with a first headache were excluded. Statistical significance was assessed by using chi-square or Fisher's exact test for categorical variables and Student's t-test for continuous variables. Patients rated their pain on a 10-centimeter visual analog scale (VAS) prior to drug administration and at 5, 10, 15, 20, and 30 minutes after the initial dose. Medication was either 1 mL of 4% lidocaine or normal saline (placebo) intranasally in split doses 2 minutes apart and intravenous prochlorperazine. Medications were packaged so physicians and patients were unaware of the contents. Successful pain relief was achieved if there was a 50% reduction in pain score or a score below 2.5 cm on the VAS. RESULTS: Twenty-seven patients received lidocaine and 22 placebo. No significant difference was observed between groups in initial pain scores, 8.4 (95% CI = 7.8 to 9.0) lidocaine and 8.6 (95% CI = 8.0 to 9.2) placebo (p = 0.75). Two of 27 patients (7.4%, 95% CI = 0.8, 24.3) in the lidocaine group and three of 22 patients (13.6%, 95% CI = 2.8 to 34.9) in the placebo group had immediate successful pain relief (p = 0.47), with average pain scores of 6.9 (95% CI = 5.9 to 7.8) and 7.0 (95% CI = 5.8 to 8.2), respectively. No difference in pain relief was detected at subsequent measurements. CONCLUSION: There was no evidence that intranasal lidocaine provided rapid relief for migraine headache pain in the emergency department setting.
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<a href="http://doi.org/10.1111/j.1553-2712.2001.tb02111.x" target="_blank" rel="noreferrer noopener">10.1111/j.1553-2712.2001.tb02111.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Administration
Adolescent
Adult
Anesthetics
Blanda M
Confidence Intervals
Department of Emergency Medicine
Double-Blind Method
Female
Gerson L W
Hospitals
Humans
Intranasal
Lidocaine/*administration & dosage
Local
Male
Middle Aged
Migraine without Aura/diagnosis/*drug therapy
NEOMED College of Medicine
Ohio
Pain Measurement
Patient Satisfaction
Reference Values
Rench T
Severity of Illness Index
Teaching
Treatment Outcome
Weigand J V