1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1186/1465-9921-8-27" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/1465-9921-8-27</a>
Pages
27–27
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stimulation of MAP kinase pathways after maternal IL-1beta exposure induces fetal lung fluid absorption in guinea pigs.
Publisher
An entity responsible for making the resource available
Respiratory research
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-03
Subject
The topic of the resource
Absorption/drug effects; Animal/*metabolism; Animals; Body Fluids/*metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Fetus/metabolism; Gestational Age; Guinea Pigs; Hydrocortisone/*metabolism; Injections; Interleukin-1beta/administration & dosage/*pharmacology; Lung/*embryology; Mitogen-Activated Protein Kinase Kinases/metabolism; Mitogen-Activated Protein Kinases/*metabolism; Pregnancy; Rats; Recombinant Proteins/administration & dosage/pharmacology; Subcutaneous
Creator
An entity primarily responsible for making the resource
Bhattacharjee Reshma; Li Tianbo; Koshy Shyny; Beard LaMonta L; Sharma Kapil; Carter Ethan P; Garat Chrystelle; Folkesson Hans G
Description
An account of the resource
BACKGROUND: We tested the hypothesis that maternal interleukin-1beta (IL-1beta) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. METHODS: IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for three days. Fetuses were obtained by abdominal hysterotomy and instilled with isosmolar 5% albumin into the lungs and lung fluid movement was measured over 1 h by mass balance. MAP kinase expression was measured by western blot. RESULTS: Lung fluid absorption was induced at 61 days (D) gestation and stimulated at 68D gestation by IL-1beta. Maternal IL-1beta pretreatment upregulated ERK and upstream MEK expression at both 61 and 68D gestation, albeit being much more pronounced at 61D gestation. U0126 instillation completely blocked IL-1beta-induced lung fluid absorption as well as IL-1beta-induced/stimulated ERK expression. Cortisol synthesis inhibition by metyrapone attenuated ERK expression and lung fluid absorption in IL-1beta-pretreated fetal lungs. JNK expression after maternal
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/1465-9921-8-27" target="_blank" rel="noreferrer noopener">10.1186/1465-9921-8-27</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Absorption/drug effects
Animal/*metabolism
Animals
Beard LaMonta L
Bhattacharjee Reshma
Body Fluids/*metabolism
Carter Ethan P
Extracellular Signal-Regulated MAP Kinases/metabolism
Female
Fetus/metabolism
Folkesson Hans G
Garat Chrystelle
Gestational Age
Guinea Pigs
Hydrocortisone/*metabolism
Injections
Interleukin-1beta/administration & dosage/*pharmacology
Koshy Shyny
Li Tianbo
Lung/*embryology
Mitogen-Activated Protein Kinase Kinases/metabolism
Mitogen-Activated Protein Kinases/*metabolism
Pregnancy
Rats
Recombinant Proteins/administration & dosage/pharmacology
Respiratory research
Sharma Kapil
Subcutaneous
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/me.2009-0482" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/me.2009-0482</a>
Pages
1151–1164
Issue
6
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Publisher
An entity responsible for making the resource available
Molecular endocrinology (Baltimore, Md.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
Calcitriol/*metabolism; Calcitriol/pharmacology; Cell Membrane/drug effects/metabolism; Cell Nucleus/drug effects/metabolism; Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics; Enzyme Activation/drug effects; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Genetic/genetics; Hep G2 Cells; Hepatocyte Nuclear Factor 4/metabolism; Hepatocytes/*drug effects/enzymology/*metabolism; Humans; Intracellular Space/drug effects/metabolism; Ligands; Lithocholic Acid/*pharmacology; Mitogen-Activated Protein Kinase Kinases/metabolism; Phosphorylation/drug effects; Phosphotyrosine/metabolism; Promoter Regions; Protein Kinase Inhibitors/pharmacology; Protein Transport/drug effects; Proto-Oncogene Proteins c-raf/metabolism; Receptors; Retinoid X Receptor alpha/metabolism; Signal Transduction/*drug effects; src-Family Kinases/metabolism; Steroid Hydroxylases/genetics/metabolism; Vitamin D3 24-Hydroxylase
Creator
An entity primarily responsible for making the resource
Han Shuxin; Li Tiangang; Ellis Ewa; Strom Stephen; Chiang John Y L
Description
An account of the resource
Vitamin D receptor (VDR) is activated by natural ligands, 1alpha,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/me.2009-0482" target="_blank" rel="noreferrer noopener">10.1210/me.2009-0482</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Calcitriol/*metabolism
Calcitriol/pharmacology
Cell Membrane/drug effects/metabolism
Cell Nucleus/drug effects/metabolism
Chiang John Y L
Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics
Department of Integrative Medical Sciences
Ellis Ewa
Enzyme Activation/drug effects
Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors
Genetic/genetics
Han Shuxin
Hep G2 Cells
Hepatocyte Nuclear Factor 4/metabolism
Hepatocytes/*drug effects/enzymology/*metabolism
Humans
Intracellular Space/drug effects/metabolism
Li Tiangang
Ligands
Lithocholic Acid/*pharmacology
Mitogen-Activated Protein Kinase Kinases/metabolism
Molecular endocrinology (Baltimore, Md.)
NEOMED College of Medicine
Phosphorylation/drug effects
Phosphotyrosine/metabolism
Promoter Regions
Protein Kinase Inhibitors/pharmacology
Protein Transport/drug effects
Proto-Oncogene Proteins c-raf/metabolism
Receptors
Retinoid X Receptor alpha/metabolism
Signal Transduction/*drug effects
src-Family Kinases/metabolism
Steroid Hydroxylases/genetics/metabolism
Strom Stephen
Vitamin D3 24-Hydroxylase