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Text
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URL Address
<a href="http://doi.org/10.1152/ajpgi.00207.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpgi.00207.2004</a>
Pages
G685–695
Issue
4
Volume
288
Dublin Core
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Title
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Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.
Publisher
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American journal of physiology. Gastrointestinal and liver physiology
Date
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2005
2005-04
Subject
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Cell Line; Chenodeoxycholic Acid/pharmacology; Chromosome Mapping; DNA-Binding Proteins/genetics/metabolism; Enzyme Inhibitors/pharmacology; Gene Expression Regulation/*drug effects; Genetic/drug effects; Genetic/physiology; Hepatocyte Nuclear Factor 4; Hepatocytes/metabolism; Humans; Interleukin-1/*pharmacology; MAP Kinase Signaling System/drug effects/physiology; Messenger/antagonists & inhibitors; Mitogen-Activated Protein Kinase 8/metabolism; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Phosphoproteins/genetics/metabolism; Phosphorylation; Promoter Regions; Response Elements/genetics; RNA; Steroid 12-alpha-Hydroxylase/antagonists & inhibitors/*genetics; Transcription; Transcription Factors/genetics/metabolism
Creator
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Jahan Asmeen; Chiang John Y L
Description
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Sterol 12alpha-hydroxylase (CYP8B1) catalyzes cholic acid synthesis in the liver and is feedback inhibited by bile acids. In addition to activating farnesoid X receptor (nuclear receptor subfamily 1H4), bile acids also induce inflammatory cytokines in hepatocytes. The objective of this study was to investigate the mechanism by which inflammatory cytokines inhibit human CYP8B1 gene transcription. Real-time PCR assays revealed that both chenodeoxycholic acid (CDCA) and interleukin-1beta (IL-1beta) markedly reduced CYP8B1, cholesterol 7alpha-hydroxylase CYP7A1 and hepatic nuclear factor 4alpha (HNF4alpha) mRNA expression levels in human primary hepatocytes. However, CDCA induced, but
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpgi.00207.2004" target="_blank" rel="noreferrer noopener">10.1152/ajpgi.00207.2004</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
American journal of physiology. Gastrointestinal and liver physiology
Cell Line
Chenodeoxycholic Acid/pharmacology
Chiang John Y L
Chromosome Mapping
Department of Integrative Medical Sciences
DNA-Binding Proteins/genetics/metabolism
Enzyme Inhibitors/pharmacology
Gene Expression Regulation/*drug effects
Genetic/drug effects
Genetic/physiology
Hepatocyte Nuclear Factor 4
Hepatocytes/metabolism
Humans
Interleukin-1/*pharmacology
Jahan Asmeen
MAP Kinase Signaling System/drug effects/physiology
Messenger/antagonists & inhibitors
Mitogen-Activated Protein Kinase 8/metabolism
Mitogen-Activated Protein Kinases/antagonists & inhibitors
NEOMED College of Medicine
Phosphoproteins/genetics/metabolism
Phosphorylation
Promoter Regions
Response Elements/genetics
RNA
Steroid 12-alpha-Hydroxylase/antagonists & inhibitors/*genetics
Transcription
Transcription Factors/genetics/metabolism