2
40
108
-
Text
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URL Address
<a href="http://doi.org/10.1155/2013/873595" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2013/873595</a>
Pages
873595–873595
Volume
2013
Dublin Core
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Title
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A gradient boosting algorithm for survival analysis via direct optimization of concordance index.
Publisher
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Computational and mathematical methods in medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-07
Subject
The topic of the resource
*Survival Analysis; Algorithms; Artificial Intelligence; Breast Neoplasms/*epidemiology/*mortality; Clinical; Databases; Decision Support Systems; Factual; Female; Humans; Internet; Models; Prognosis; Proportional Hazards Models; Software; Theoretical
Creator
An entity primarily responsible for making the resource
Chen Yifei; Jia Zhenyu; Mercola Dan; Xie Xiaohui
Description
An account of the resource
Survival analysis focuses on modeling and predicting the time to an event of interest. Many statistical models have been proposed for survival analysis. They often impose strong assumptions on hazard functions, which describe how the risk of an event changes over time depending on covariates associated with each individual. In particular, the prevalent proportional hazards model assumes that covariates are multiplicatively related to the hazard. Here we propose a nonparametric model for survival analysis that does not explicitly assume particular forms of hazard functions. Our nonparametric model utilizes an ensemble of regression trees to determine how the hazard function varies according to the associated covariates. The ensemble model is trained using a gradient boosting method to optimize a smoothed approximation of the concordance index, which is one of the most widely used metrics in survival model performance evaluation. We implemented our model in a software package called GBMCI (gradient boosting machine for concordance index) and benchmarked the performance of our model against other popular survival models with a large-scale breast cancer prognosis dataset. Our experiment shows that GBMCI consistently outperforms other methods based on a number of covariate settings. GBMCI is implemented in R and is freely available online.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2013/873595" target="_blank" rel="noreferrer noopener">10.1155/2013/873595</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Survival Analysis
2013
Algorithms
Artificial Intelligence
Breast Neoplasms/*epidemiology/*mortality
Chen Yifei
Clinical
Computational and mathematical methods in medicine
Databases
Decision Support Systems
Factual
Female
Humans
Internet
Jia Zhenyu
Mercola Dan
Models
Prognosis
Proportional Hazards Models
Software
Theoretical
Xie Xiaohui
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.90390.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.90390.2008</a>
Pages
629–645
Issue
2
Volume
100
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intracellular recordings from combination-sensitive neurons in the inferior colliculus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-08
Subject
The topic of the resource
Acoustic Stimulation/methods; Afferent/classification/*physiology; Animals; Auditory/physiology; Biological; Chiroptera; Evoked Potentials; Inferior Colliculi/*cytology; Membrane Potentials/physiology/radiation effects; Models; Neural Inhibition/*physiology; Neural Pathways/physiology; Neurons; Psychophysics; Reaction Time; Wakefulness
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Voytenko Sergiy; Gans Donald; Galazyuk Alexander; Wenstrup Jeffrey
Description
An account of the resource
In vertebrate auditory systems, specialized combination-sensitive neurons analyze complex vocal signals by integrating information across multiple frequency bands. We studied combination-sensitive interactions in neurons of the inferior colliculus (IC) of awake mustached bats, using intracellular somatic recording with sharp electrodes. Facilitated combinatorial neurons are coincidence detectors, showing maximum facilitation when excitation from low- and high-frequency stimuli coincide. Previous work showed that facilitatory interactions originate in the IC, require both low and high frequency-tuned glycinergic inputs, and are independent of glutamatergic inputs. These results suggest that glycinergic inputs evoke facilitation through either postinhibitory rebound or direct depolarizing mechanisms. However, in 35 of 36 facilitated neurons, we observed no evidence of low frequency-evoked transient hyperpolarization or depolarization that was closely related to response facilitation. Furthermore, we observed no evidence of shunting inhibition that might conceal inhibitory inputs. Since these facilitatory interactions originate in IC neurons, the results suggest that inputs underlying facilitation are electrically segregated from the soma. We also recorded inhibitory combinatorial interactions, in which low frequency sounds suppress responses to higher frequency signals. In 43% of 118 neurons, we observed low frequency-evoked hyperpolarizations associated with combinatorial inhibition. For these neurons, we conclude that low frequency-tuned inhibitory inputs terminate on neurons primarily excited by high-frequency signals; these inhibitory inputs may create or enhance inhibitory combinatorial interactions. In the remainder of inhibited combinatorial neurons (57%), we observed no evidence of low frequency-evoked hyperpolarizations, consistent with observations that inhibitory combinatorial responses may originate in lateral lemniscal nuclei.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.90390.2008" target="_blank" rel="noreferrer noopener">10.1152/jn.90390.2008</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
Acoustic Stimulation/methods
Afferent/classification/*physiology
Animals
Auditory/physiology
Biological
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk Alexander
Gans Donald
Inferior Colliculi/*cytology
Journal of neurophysiology
Membrane Potentials/physiology/radiation effects
Models
NEOMED College of Medicine
Neural Inhibition/*physiology
Neural Pathways/physiology
Neurons
Peterson Diana Coomes
Psychophysics
Reaction Time
Voytenko Sergiy
Wakefulness
Wenstrup Jeffrey
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1991.66.5.1538</a>
Pages
1538–1548
Issue
5
Volume
66
Dublin Core
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Title
A name given to the resource
Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Animals; Bicuculline/analogs & derivatives/pharmacology; Chlorides/pharmacology; Dendrites/drug effects/*physiology; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/*physiology; Hippocampus/*physiology; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials/drug effects; Models; Neurological; Neurons/drug effects/*physiology; Organophosphorus Compounds/pharmacology; Pyramidal Tracts/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABAA and late, GABAB receptor-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) and were not changed by the GABAB receptor antagonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">10.1152/jn.1991.66.5.1538</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Bicuculline/analogs & derivatives/pharmacology
Borroni A M
Chlorides/pharmacology
Dendrites/drug effects/*physiology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lambert N A
Mathematics
Membrane Potentials/drug effects
Models
Neurological
Neurons/drug effects/*physiology
Organophosphorus Compounds/pharmacology
Pyramidal Tracts/drug effects/*physiology
Quinoxalines/pharmacology
Rats
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.01152.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.01152.2004</a>
Pages
3294–3312
Issue
6
Volume
93
Dublin Core
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Title
A name given to the resource
Roles of inhibition in creating complex auditory responses in the inferior colliculus: facilitated combination-sensitive neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-06
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/*physiology; Animals; Auditory Pathways/physiology; Bicuculline/pharmacology; Cell Count; Drug Interactions; GABA Antagonists/pharmacology; Glycine Agents/pharmacology; Inferior Colliculi/*cytology; Iontophoresis/methods; Models; Neural Inhibition/drug effects/*physiology; Neurological; Neurons/classification/drug effects/*physiology/radiation effects; Otters; Reaction Time/*physiology/radiation effects; Regression Analysis; Strychnine/pharmacology; Time Factors; Wakefulness/physiology
Creator
An entity primarily responsible for making the resource
Nataraj Kiran; Wenstrup Jeffrey J
Description
An account of the resource
We studied roles of inhibition on temporally sensitive facilitation in combination-sensitive neurons from the mustached bat's inferior colliculus (IC). In these integrative neurons, excitatory responses to best frequency (BF) tones are enhanced by much lower frequency signals presented in a specific temporal relationship. Most facilitated neurons (76%) showed inhibition at delays earlier than or later than the delays causing facilitation. The timing of inhibition at earlier delays was closely related to the best delay of facilitation, but the inhibition had little influence on the duration or strength of the facilitatory interaction. Local iontophoretic application of antagonists to receptors for glycine (strychnine, STRY) and gamma-aminobutyric acid (GABA) (bicuculline, BIC) showed that STRY abolished facilitation in 96% of tested units, but BIC eliminated facilitation in only 28%. This suggests that facilitatory interactions are created in IC and reveals a differential role for these neurotransmitters. The facilitation may be created by coincidence of a postinhibitory rebound excitation activated by the low-frequency signal with the BF-evoked excitation. Unlike facilitation, inhibition at earlier delays was not eliminated by application of antagonists, suggesting an origin in lower brain stem nuclei. However, inhibition at delays later than facilitation, like facilitation itself, appears to originate within IC and to be more dependent on glycinergic than GABAergic mechanisms. Facilitatory and inhibitory interactions displayed by these combination-sensitive neurons encode information within sonar echoes and social vocalizations. The results indicate that these complex response properties arise through a series of neural interactions in the auditory brain stem and midbrain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.01152.2004" target="_blank" rel="noreferrer noopener">10.1152/jn.01152.2004</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Acoustic Stimulation/methods
Action Potentials/*physiology
Animals
Auditory Pathways/physiology
Bicuculline/pharmacology
Cell Count
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Drug Interactions
GABA Antagonists/pharmacology
Glycine Agents/pharmacology
Inferior Colliculi/*cytology
Iontophoresis/methods
Journal of neurophysiology
Models
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurological
Neurons/classification/drug effects/*physiology/radiation effects
Otters
Reaction Time/*physiology/radiation effects
Regression Analysis
Strychnine/pharmacology
Time Factors
Wakefulness/physiology
Wenstrup Jeffrey J
-
Text
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URL Address
<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00883.2006</a>
Pages
1018–1029
Issue
2
Volume
97
Dublin Core
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Title
A name given to the resource
Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Amino Acids/pharmacology; Animals; Chickens/*physiology; Cochlear Nucleus/*cytology/*physiology; Electric Stimulation; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/physiology; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; GABA-B/physiology; gamma-Aminobutyric Acid/*physiology; Glycine/analogs & derivatives/pharmacology; In Vitro Techniques; Kinetics; Membrane Potentials/drug effects; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology; Models; Neurological; Neurons/*physiology; Patch-Clamp Techniques; Receptors; Resorcinols/pharmacology; Synapses/physiology; Synaptic Transmission/*physiology; Xanthenes/pharmacology
Creator
An entity primarily responsible for making the resource
Lu Yong
Description
An account of the resource
GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic glutamate receptors (mGluRs) with whole cell recordings in brain slice preparations. I found that tACPD, a nonspecific mGluR agonist, exerted dose-dependent suppression on evoked inhibitory postsynaptic currents (eIPSCs) in NM neurons. At concentrations of 100 or 200 microM, tACPD increased the failure rate of GABAergic transmission. Agonists for group I (3,5-DHPG, 200 microM), group II (DCG-IV, 2 microM), and group III (L-AP4, 10 microM) mGluRs produced a significant reduction in the amplitude of eIPSCs and a significant increase in failure rate, indicating the involvement of multiple mGluRs in this modulation. The frequency, but not the amplitude, of miniature IPSCs (mIPSCs) was decreased significantly by 3,5-DHPG or DCG-IV. Neither frequency nor amplitude of mIPSCs was affected by L-AP4. mGluR antagonists LY341495 (20 microM) plus CPPG (10 microM) significantly increased the amplitude of eIPSCs, indicating that endogenous mGluR activity suppresses GABA release to NM neurons. Furthermore, blockage of mGluRs increased GABA-evoked discharges recorded under physiological Cl(-) concentrations, whereas tACPD (100 microM) eliminated them. The results indicate that mGluRs play important roles in achieving balanced excitation and inhibition in NM and preserving fidelity of temporal information encoded by NM neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">10.1152/jn.00883.2006</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2-Amino-5-phosphonovalerate/pharmacology
2007
Amino Acids/pharmacology
Animals
Chickens/*physiology
Cochlear Nucleus/*cytology/*physiology
Department of Anatomy & Neurobiology
Electric Stimulation
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/physiology
GABA-B Receptor Agonists
GABA-B Receptor Antagonists
GABA-B/physiology
gamma-Aminobutyric Acid/*physiology
Glycine/analogs & derivatives/pharmacology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lu Yong
Membrane Potentials/drug effects
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology
Models
NEOMED College of Medicine
Neurological
Neurons/*physiology
Patch-Clamp Techniques
Receptors
Resorcinols/pharmacology
Synapses/physiology
Synaptic Transmission/*physiology
Xanthenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00451.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00451.2009</a>
Pages
2050–2061
Issue
4
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Responses in the inferior colliculus of the guinea pig to concurrent harmonic series and the effect of inactivation of descending controls.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-04
Subject
The topic of the resource
*Acoustic Stimulation; Action Potentials/physiology; Animal; Animals; Auditory Cortex/*physiology; Auditory Pathways/*physiology; Female; Guinea Pigs; Inferior Colliculi/*physiology; Male; Models; Pitch Perception/physiology
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Shackleton Trevor M; Palmer Alan R
Description
An account of the resource
One of the fundamental questions of auditory research is how sounds are segregated because, in natural environments, multiple sounds tend to occur at the same time. Concurrent sounds, such as two talkers, physically add together and arrive at the ear as a single input sound wave. The auditory system easily segregates this input into a coherent perception of each of the multiple sources. A common feature of speech and communication calls is their harmonic structure and in this report we used two harmonic complexes to study the role of the corticofugal pathway in the processing of concurrent sounds. We demonstrate that, in the inferior colliculus (IC) of the anesthetized guinea pig, deactivation of the auditory cortex altered the temporal and/or the spike response to the concurrent, monaural harmonic complexes. More specifically, deactivating the auditory cortex altered the representation of the relative level of the complexes. This suggests that the auditory cortex modulates the representation of the level of two harmonic complexes in the IC. Since sound level is a cue used in the segregation of auditory input, the corticofugal pathway may play a role in this segregation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00451.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00451.2009</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Acoustic Stimulation
2010
Action Potentials/physiology
Animal
Animals
Auditory Cortex/*physiology
Auditory Pathways/*physiology
Female
Guinea Pigs
Inferior Colliculi/*physiology
Journal of neurophysiology
Male
Models
Nakamoto Kyle T
Palmer Alan R
Pitch Perception/physiology
Shackleton Trevor M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1993.74.6.3068" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1993.74.6.3068</a>
Pages
3068–3072
Issue
6
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of peak inspiratory pressure on the filtration coefficient in the isolated perfused rat lung.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-06
Subject
The topic of the resource
Animals; Biological; Body Fluids/physiology; Capillary Permeability; Evaluation Studies as Topic; In Vitro Techniques; Lung/blood supply/*physiology; Male; Models; Perfusion; Positive-Pressure Respiration; Pressure; Rats; Respiration/physiology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Omlor G; Niehaus G D; Maron M B
Description
An account of the resource
Positive inspiratory pressure- (PIP) ventilated, isolated rat lungs become edematous when perfused at rates approximately the normal cardiac output. The study was conducted to test the hypothesis that high peak inspiratory pressures contribute to the edema development. Five isolated lungs were perfused at a rate of 24.4 +/- 2.2 ml.min-1.100 g body wt-1 with 40% whole blood (diluted with saline containing 4.0 g/100 ml bovine serum albumin) and ventilated with peak pressures ranging from 0 to 20 mmHg. The lungs exhibited edema at PIP values \textgreater 9.3 mmHg. The stable pulmonary vascular pressure and resistance suggested that the edema may have resulted from a PIP-induced increase in microvascular permeability. In a second study, the stability of the preparation was evaluated during a 3-h test period. Seven lungs were ventilated at a peak inspiratory pressure of 8.0 mmHg and perfused at 26.8 +- 1.7 ml.min-1 x 100 g body wt-1. Microvascular integrity was maintained for approximately 2 h as indicated by filtration coefficient measurements of 0.175 +/- 0.068, 0.197 +/- 0.066, and 0.169 +/- 0.067 g.min-1 x mmHg-1 x 100 g-1 at 25, 70, and 115 min, respectively, after initiation of the study. The results suggest that isolated rat lungs perfused at rates that parallel normal rat cardiac output and ventilated at low peak inspiratory pressures provide a viable mechanism for evaluation of the pathophysiology of microvascular injury.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1993.74.6.3068" target="_blank" rel="noreferrer noopener">10.1152/jappl.1993.74.6.3068</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Biological
Body Fluids/physiology
Capillary Permeability
Department of Integrative Medical Sciences
Evaluation Studies as Topic
In Vitro Techniques
Journal of applied physiology (Bethesda, Md. : 1985)
Lung/blood supply/*physiology
Male
Maron M B
Models
NEOMED College of Medicine
Niehaus G D
Omlor G
Perfusion
Positive-Pressure Respiration
Pressure
Rats
Respiration/physiology
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1992.73.1.50" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1992.73.1.50</a>
Pages
50–58
Issue
1
Volume
73
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pulmonary vascular protein sieving capability after exposure to high vascular pressures.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-07
Subject
The topic of the resource
Animals; Barotrauma/physiopathology; Blood Pressure/physiology; Blood Proteins/chemistry/*metabolism; Chemical; Dogs; Electrophoresis; Hypertension; Lymph/cytology/metabolism; Male; Models; Muscle; Permeability; Polyacrylamide Gel; Pulmonary Circulation/*physiology; Pulmonary Edema/physiopathology; Pulmonary/*physiopathology; Smooth; Vascular/*physiology
Creator
An entity primarily responsible for making the resource
Bosso F J; Maron M B; Pilati C F; Jarjoura D G
Description
An account of the resource
We evaluated the ability of the canine in situ left lower lobe (LLL) vasculature to sieve endogenous plasma proteins of various molecular radii (34-124 A) after LLL arterial pressure had been transiently elevated to 23.8 +/- 0.9 (control group, n = 5) or 92.3 +/- 1.4 (SE) Torr (high-pressure group, n = 9) by restricting LLL venous outflow under conditions of constant flow. After LLL flow was returned to natural perfusion, left atrial pressure was elevated in step increments, and LLL lymph and blood samples were collected until filtration-independent lymph-to-plasma protein concentration ratios (CL/CP) were obtained. The osmotic reflection coefficients (sigma d) for total proteins and seven protein fractions (separated by gradient gel electrophoresis) were calculated. The average total protein sigma d of the high-pressure group [0.51 +/- 0.06 (SE)] was significantly lower than that of the control group (0.68 +/- 0.03). Several LLLs of the high-pressure group, however, exhibited normal sigma d's. Protein fraction CL/CP's decreased with increasing molecular radius in both groups, but the CL/CP-molecular radius relationship was displaced upward in the high-pressure group. Pore analysis suggested that the decreases in sigma d could be explained by increases in the fractional flow through a large-pore system.
Identifier
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<a href="http://doi.org/10.1152/jappl.1992.73.1.50" target="_blank" rel="noreferrer noopener">10.1152/jappl.1992.73.1.50</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Animals
Barotrauma/physiopathology
Blood Pressure/physiology
Blood Proteins/chemistry/*metabolism
Bosso F J
Chemical
Dogs
Electrophoresis
Hypertension
Jarjoura D G
Journal of applied physiology (Bethesda, Md. : 1985)
Lymph/cytology/metabolism
Male
Maron M B
Models
Muscle
Permeability
Pilati C F
Polyacrylamide Gel
Pulmonary Circulation/*physiology
Pulmonary Edema/physiopathology
Pulmonary/*physiopathology
Smooth
Vascular/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1988.64.4.1746" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1988.64.4.1746</a>
Pages
1746–1748
Issue
4
Volume
64
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Calculation of the reflection coefficient from measurements of endogenous vascular indicators.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-04
Subject
The topic of the resource
Animals; Blood Proteins/*analysis; Blood Volume; Capillary Permeability; Filtration; Humans; Mathematics; Methods; Models; Theoretical
Creator
An entity primarily responsible for making the resource
Maron M B; Pilati C F
Description
An account of the resource
The solvent drag reflection coefficient (sigma) for total proteins can be estimated by comparing the relative degrees of concentration of erythrocytes and plasma proteins that occur during fluid filtration in an isolated perfused organ. In this analysis, we evaluated the accuracy of equations proposed by Pilati and Maron [Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H1-H7, 1984] and Wolf et al. [Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H194-H204, 1987] to calculate sigma from these concentration changes. We calculated sigma with each equation using data generated from a mathematical model of fluid and solute flux in membranes with known sigma's. We found that the equation of Wolf et al. provided the closest approximation to the true sigma over the entire range of filtration fractions tested (0.1-0.6), with the differences between the two equations increasing with filtration fraction. At low filtration fractions, the difference in sigma obtained using either approach was found to be inconsequential. At larger filtration fractions, a closer approximation of the true sigma can be obtained using the equation of Wolf et al.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1988.64.4.1746" target="_blank" rel="noreferrer noopener">10.1152/jappl.1988.64.4.1746</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Blood Proteins/*analysis
Blood Volume
Capillary Permeability
Filtration
Humans
Journal of applied physiology (Bethesda, Md. : 1985)
Maron M B
Mathematics
Methods
Models
Pilati C F
Theoretical
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1994.266.2.H531" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1994.266.2.H531</a>
Pages
H531–539
Issue
2
Volume
266
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Myocardial work load is a major determinant of norepinephrine-induced left ventricular dysfunction.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-02
Subject
The topic of the resource
Anesthesia; Animals; Blood Pressure/*drug effects; Cardiovascular; Consciousness; Diastole/drug effects; Dose-Response Relationship; Drug; General; Heart Rate/*drug effects; Heart/drug effects/*physiology; Left/drug effects/*physiology; Models; Norepinephrine/*pharmacology; Pentobarbital; Rabbits; Systole/drug effects; Time Factors; Ventricular Function
Creator
An entity primarily responsible for making the resource
Bosso F J; Allman F D; Pilati C F
Description
An account of the resource
This study was conducted to determine whether increased myocardial energy demand plays a role in norepinephrine (NE)-induced left ventricular (LV) dysfunction. A range of arterial pressure-heart rate (P-R) products (myocardial energy demand) was produced in both conscious and pentobarbital sodium-anesthetized rabbits with the same dose of NE (10 micrograms priming bolus plus 2.5 micrograms.kg-1 x min-1 for 2.5 h). After NE treatment, LV function was evaluated in vitro and found to be markedly diminished in the rabbits that had an elevated P-R product. In contrast, LV function was not significantly affected when the P-R product was maintained near control levels during NE treatment. In separate experiments, rabbit hearts were isolated and exposed to NE (10,000 or 50,000 pg/ml) for 2.5 h under low P-R product conditions. These hearts exhibited a dose-dependent decrease in LV function that was modest compared with that observed in rabbits that had elevated P-R products during in vivo NE treatment. Our results suggest that high concentrations of NE may cause modest degrees of LV dysfunction independently of increases in myocardial energy demand, but the LV dysfunction is exacerbated when myocardial energy demand is elevated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1994.266.2.H531" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1994.266.2.H531</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Allman F D
Anesthesia
Animals
Blood Pressure/*drug effects
Bosso F J
Cardiovascular
Consciousness
Diastole/drug effects
Dose-Response Relationship
Drug
General
Heart Rate/*drug effects
Heart/drug effects/*physiology
Left/drug effects/*physiology
Models
Norepinephrine/*pharmacology
Pentobarbital
Pilati C F
Rabbits
Systole/drug effects
The American journal of physiology
Time Factors
Ventricular Function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/pr.113.008201" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/pr.113.008201</a>
Pages
948–983
Issue
4
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bile acid signaling in metabolic disease and drug therapy.
Publisher
An entity responsible for making the resource available
Pharmacological reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-10
Subject
The topic of the resource
Animals; Bile Acids and Salts/biosynthesis/*metabolism/therapeutic use; Biological; Circadian Rhythm/physiology; G-Protein-Coupled/metabolism; Glucose/metabolism; Humans; Lipid Metabolism/physiology; Liver/metabolism; Metabolic Diseases/*drug therapy/*metabolism; Microbiota/physiology; MicroRNAs/metabolism; Models; Receptors; Signal Transduction/physiology
Creator
An entity primarily responsible for making the resource
Li Tiangang; Chiang John Y L
Description
An account of the resource
Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates hepatobiliary secretion of lipids, lipophilic metabolites, and xenobiotics. In the intestine, bile acids are essential for the absorption, transport, and metabolism of dietary fats and lipid-soluble vitamins. Extensive research in the last 2 decades has unveiled new functions of bile acids as signaling molecules and metabolic integrators. The bile acid-activated nuclear receptors farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, vitamin D receptor, and G protein-coupled bile acid receptor play critical roles in the regulation of lipid, glucose, and energy metabolism, inflammation, and drug metabolism and detoxification. Bile acid synthesis exhibits a strong diurnal rhythm, which is entrained by fasting and refeeding as well as nutrient status and plays an important role for maintaining metabolic homeostasis. Recent research revealed an interaction of liver bile acids and gut microbiota in the regulation of liver metabolism. Circadian disturbance and altered gut microbiota contribute to the pathogenesis of liver diseases, inflammatory bowel diseases, nonalcoholic fatty liver disease, diabetes, and obesity. Bile acids and their derivatives are potential therapeutic agents for treating metabolic diseases of the liver.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/pr.113.008201" target="_blank" rel="noreferrer noopener">10.1124/pr.113.008201</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Bile Acids and Salts/biosynthesis/*metabolism/therapeutic use
Biological
Chiang John Y L
Circadian Rhythm/physiology
Department of Integrative Medical Sciences
G-Protein-Coupled/metabolism
Glucose/metabolism
Humans
Li Tiangang
Lipid Metabolism/physiology
Liver/metabolism
Metabolic Diseases/*drug therapy/*metabolism
Microbiota/physiology
MicroRNAs/metabolism
Models
NEOMED College of Medicine
Pharmacological reviews
Receptors
Signal Transduction/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/jep.13042" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/jep.13042</a>
Pages
1293–1309
Issue
6
Volume
24
Dublin Core
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Title
A name given to the resource
Exploring comorbid depression and physical health trajectories: A case-based computational modelling approach.
Publisher
An entity responsible for making the resource available
Journal of evaluation in clinical practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-12
Subject
The topic of the resource
artificial intelligence; case-based modelling; Child Abuse; cluster analysis; comorbid depression and physical health; Comorbidity; complexity theory; Computer Simulation; Depression – Therapy; differential equations; Health Status; Human; Intimate Partner Violence; longitudinal analysis; Models; nonlinear dynamics; primary care; Primary Health Care; Prospective Studies; Questionnaires; Research Personnel; Scales; Theoretical
Creator
An entity primarily responsible for making the resource
Castellani Brian; Griffiths Frances; Rajaram Rajeev; Gunn Jane
Description
An account of the resource
While comorbid depression/physical health is a major clinical concern, the conventional methods of medicine make it difficult to model the complexities of this relationship. Such challenges include cataloguing multiple trends, developing multiple complex aetiological explanations, and modelling the collective large-scale dynamics of these trends. Using a case-based complexity approach, this study engaged in a richly described case study to demonstrate the utility of computational modelling for primary care research. N = 259 people were subsampled from the Diamond database, one of the largest primary care depression cohort studies worldwide. A global measure of depressive symptoms (PHQ-9) and physical health (PCS-12) were assessed at 3, 6, 9, and 12 months and then annually for a total of 7 years. Eleven trajectories and 2 large-scale collective dynamics were identified, revealing that while depression is comorbid with poor physical health, chronic illness is often low dynamic and not always linked to depression. Also, some of the cases in the unhealthy and oscillator trends remain ill without much chance of improvement. Finally, childhood abuse, partner violence, and negative life events are greater amongst unhealthy trends. Computational modelling offers a major advance for health researchers to account for the diversity of primary care patients and for developing better prognostic models for team-based interdisciplinary care.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/jep.13042" target="_blank" rel="noreferrer noopener">10.1111/jep.13042</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Artificial Intelligence
case-based modelling
Castellani Brian
Child Abuse
Cluster Analysis
comorbid depression and physical health
Comorbidity
complexity theory
Computer Simulation
Depression – Therapy
differential equations
Griffiths Frances
Gunn Jane
Health Status
Human
Intimate Partner Violence
Journal of evaluation in clinical practice
longitudinal analysis
Models
Nonlinear Dynamics
primary care
Primary Health Care
Prospective Studies
Questionnaires
Rajaram Rajeev
Research Personnel
Scales
Theoretical
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1749-6632.2002.tb04157.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1749-6632.2002.tb04157.x</a>
Pages
136–156
Volume
965
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-06
Subject
The topic of the resource
*Neurotoxins; *Sex Characteristics; Animals; Biological; Estrogen Antagonists/*pharmacology; Estrogens/*physiology; Female; Humans; Male; Methamphetamine/*toxicity; Mice; Models; Tamoxifen/pharmacology; Testosterone/pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; McDermott Janet L
Description
An account of the resource
In Part 1 of this report, we review data on the effects of estrogen (E), the anti-E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)-induced neurotoxicity in female and male CD-1 mice. Treatment of gonadectomized females with a physiological regimen of E significantly diminished the amount of striatal dopamine (DA) depletion to METH compared with non-E-treated mice. If these
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1749-6632.2002.tb04157.x" target="_blank" rel="noreferrer noopener">10.1111/j.1749-6632.2002.tb04157.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Neurotoxins
*Sex Characteristics
2002
Animals
Annals of the New York Academy of Sciences
Biological
Dluzen Dean E
Estrogen Antagonists/*pharmacology
Estrogens/*physiology
Female
Humans
Male
McDermott Janet L
Methamphetamine/*toxicity
Mice
Models
Tamoxifen/pharmacology
Testosterone/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1601-6343.2005.00353.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1601-6343.2005.00353.x</a>
Pages
303–312
Issue
4
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Design and assessment of a tissue-engineered model of human phalanges and a small joint.
Publisher
An entity responsible for making the resource available
Orthodontics & craniofacial research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-11
Subject
The topic of the resource
*Bioartificial Organs; *Biomimetic Materials; *Finger Joint; *Finger Phalanges; *Tissue Engineering; Animals; Biological; Bone and Bones; Cartilage; Cattle; Humans; Lactic Acid; Mice; Models; Nude; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tendons
Creator
An entity primarily responsible for making the resource
Landis W J; Jacquet R; Hillyer J; Lowder E; Yanke A; Siperko L; Asamura S; Kusuhara H; Enjo M; Chubinskaya S; Potter K; Isogai N
Description
An account of the resource
OBJECTIVES: To develop models of human phalanges and small joints by suturing different cell-polymer constructs that are then implanted in athymic (nude) mice. DESIGN: Models consisted of bovine periosteum, cartilage, and/or tendon cells seeded onto biodegradable polymer scaffolds of either polyglycolic acid (PGA) or copolymers of PGA and poly-L-lactic acid (PLLA) or poly-epsilon-caprolactone (PCL) and PLLA. Constructs were fabricated to produce a distal phalanx, middle phalanx, or distal interphalangeal joint. SETTING AND SAMPLE POPULATION: Studies of more than 250 harvested implants were conducted at the Northeastern Ohio Universities College of Medicine. EXPERIMENTAL VARIABLE: Polymer scaffold, cell type, and implantation time were examined. OUTCOME MEASURE: Tissue-engineered specimens were characterized by histology, transmission electron microscopy, in situ hybridization, laser capture microdissection and qualitative and quantitative polymerase chain reaction analysis, magnetic resonance microscopy, and X-ray microtomography. RESULTS: Over periods to 60 weeks of implantation, constructs developed through vascularity from host mice; formed new cartilage, bone, and/or tendon; expressed characteristic genes of bovine origin, including type I, II and X collagen, osteopontin, aggrecan, biglycan, and bone sialoprotein; secreted corresponding proteins; responded to applied mechanical stimuli; and maintained shapes of human phalanges with small joints. CONCLUSION: Results give insight into construct processes of tissue regeneration and development and suggest more complete tissue-engineered cartilage, bone, and tendon models. These should have significant future scientific and clinical applications in medicine, including their use in plastic surgery, orthopaedics, craniofacial reconstruction, and teratology.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1601-6343.2005.00353.x" target="_blank" rel="noreferrer noopener">10.1111/j.1601-6343.2005.00353.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Bioartificial Organs
*Biomimetic Materials
*Finger Joint
*Finger Phalanges
*Tissue Engineering
2005
Animals
Asamura S
Biological
Bone and Bones
Cartilage
Cattle
Chubinskaya S
Enjo M
Hillyer J
Humans
Isogai N
Jacquet R
Kusuhara H
Lactic Acid
Landis W J
Lowder E
Mice
Models
Nude
Orthodontics & craniofacial research
Polyglycolic Acid
Polylactic Acid-Polyglycolic Acid Copolymer
Polymers
Potter K
Siperko L
Tendons
Yanke A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1553-2712.2003.tb00633.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1553-2712.2003.tb00633.x</a>
Pages
881–882
Issue
8
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inferences from aggregated data.
Publisher
An entity responsible for making the resource available
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-08
Subject
The topic of the resource
*Data Collection; *Data Interpretation; *Emergency Medical Services; Bias; Humans; Models; Statistical; Theoretical
Creator
An entity primarily responsible for making the resource
Jarjoura David
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1553-2712.2003.tb00633.x" target="_blank" rel="noreferrer noopener">10.1111/j.1553-2712.2003.tb00633.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Data Collection
*Data Interpretation
*Emergency Medical Services
2003
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Bias
Humans
Jarjoura David
Models
Statistical
Theoretical
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/WON.0000000000000130" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/WON.0000000000000130</a>
Pages
346–351
Issue
4
Volume
42
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Analysis of the Pressure Distribution Qualities of a Silicone Border Foam Dressing.
Publisher
An entity responsible for making the resource available
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-08
Subject
The topic of the resource
*Bandages; *Pressure; *Silicones; Adult; Body Mass Index; Comparative Studies; Convenience Sample; Data Analysis Software; Descriptive Statistics; Female; Foam Dressings; Heel; Heel – Pathology; Human; Humans; Interface Pressure; Male; Middle Age; Models; Ohio; P-Value; Pearson's Correlation Coefficient; Pressure Ulcer – Prevention and Control; Pressure Ulcer/prevention & control; Prospective Studies; Regression; Silicones; Statistical; Supine Position; Surveys; T-Tests
Creator
An entity primarily responsible for making the resource
Miller Stephannie K; Sharma Neal; Aberegg Lauren C; Blasiole Kimberly N; Fulton Judith A
Description
An account of the resource
PURPOSE: To determine whether application of a silicone foam dressing is associated with decreased interface pressures when applied to the heel. DESIGN: Prospective, within-subjects design. SUBJECTS AND SETTING: The study was conducted in a community-based hospital using a convenience sample of 50 healthy volunteers with a mean age of 39.6 years and mean body mass index of 26.6; 70% were female. METHODS: Application of the silicone border foam dressing was randomized between the left and right heels. Participants were asked to lie down in the supine position on a viscoelastic foam mattress. Interface pressure measurements were captured using a pressure mapping system; measurements were taken once with the dressing applied to the heel (intervention map) and once without (control map). Data were captured after a 4-minute time period allowing stabilization. Analysis was based on mean interface pressure; data points were collected for both heels in each of the 2 frames, yielding 4 observations per subject. RESULTS: Application of the dressing was associated with a significant decrease in average pressure measurements as compared to the heel with no dressing applied (P \textless .001). Application of the dressing did not impact pressure readings for the heel to which no dressing was applied (P = .53), and application of the dressing to either the left or right heel did not impact pressure readings (ie, the random effect was insignificant; P = .9). CONCLUSIONS: Application of a silicone border foam dressing is associated with significant reduction in interface pressure and may be considered as part of a pressure ulcer prevention program.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/WON.0000000000000130" target="_blank" rel="noreferrer noopener">10.1097/WON.0000000000000130</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Bandages
*Pressure
*Silicones
2015
Aberegg Lauren C
Adult
Blasiole Kimberly N
Body Mass Index
Comparative Studies
Convenience Sample
Data Analysis Software
Descriptive Statistics
Female
Foam Dressings
Fulton Judith A
Heel
Heel – Pathology
Human
Humans
Interface Pressure
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society
Male
Middle Age
Miller Stephannie K
Models
Ohio
P-Value
Pearson's Correlation Coefficient
Pressure Ulcer – Prevention and Control
Pressure Ulcer/prevention & control
Prospective Studies
Regression
Sharma Neal
Silicones
Statistical
Supine Position
Surveys
T-Tests
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/SPV.0000000000000394" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/SPV.0000000000000394</a>
Pages
449–456
Issue
6
Volume
23
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of Pregnancy and Delivery on Cytokine Expression in a Mouse Model of Pelvic Organ Prolapse.
Publisher
An entity responsible for making the resource available
Female pelvic medicine & reconstructive surgery
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
Amino Acid Oxidoreductases/*genetics/metabolism; Animal; Animals; Chemokine CCL7/genetics/metabolism; Chemokine CXCL12/genetics/metabolism; Delivery; Female; Humans; Knockout; Mice; Models; Obstetric/*adverse effects/methods; Pelvic Organ Prolapse/*genetics/metabolism/pathology; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Urethra/metabolism; Urinary Bladder/metabolism; Vagina/metabolism
Creator
An entity primarily responsible for making the resource
Couri Bruna M; Lenis Andrew T; Borazjani Ali; Balog Brian M; Kuang Mei; Butler Robert S; Penn Marc S; Damaser Margot S
Description
An account of the resource
OBJECTIVES: The aim of this study was to determine the effect of pregnancy and delivery mode on cytokine expression in the pelvic organs and serum of lysyl oxidase like-1 knockout (LOXL1 KO) mice, which develop pelvic organ prolapse after delivery. METHODS: Bladder, urethra, vagina, rectum, and blood were harvested from female LOXL1 KO mice during pregnancy, after vaginal or cesarean delivery, and from sham cesarean and unmanipulated controls. Pelvic organs and blood were also harvested from pregnant and vaginally delivered wild-type (WT) mice and from unmanipulated female virgin WT controls. Specimens were assessed using quantitative real-time reverse transcription polymerase chain reaction and/or enzyme-linked immunosorbent assay. RESULTS: Both CXCL12 and CCL7 mRNA were significantly up-regulated in the vagina, urethra, bladder, and rectum of pregnant LOXL1 KO mice compared with pregnant WT mice, suggesting systemic dysregulation of both of these cytokines in LOXL1 KO mice as a response to pregnancy.The differences in cytokine expression between LOXL1 KO and WT mice in pregnancy persisted after vaginal delivery. CCL7 gene expression increases faster and to a greater extent in LOXL1 KO mice, translating to longer lasting increases in CCL7 in serum of LOXL1 KO mice after vaginal delivery, compared with pregnant mice. CONCLUSIONS: Lysyl oxidase like-1 KO mice have an increased cytokine response to pregnancy perhaps because they are less able to reform and re-cross-link stretched elastin to accommodate pups, and this resultant tissue stretches during pregnancy. The up-regulation of CCL7 after delivery could provide an indicator of level of childbirth injury, to which the urethra and vagina seem to be particularly vulnerable.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/SPV.0000000000000394" target="_blank" rel="noreferrer noopener">10.1097/SPV.0000000000000394</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Amino Acid Oxidoreductases/*genetics/metabolism
Animal
Animals
Balog Brian M
Borazjani Ali
Butler Robert S
Chemokine CCL7/genetics/metabolism
Chemokine CXCL12/genetics/metabolism
Couri Bruna M
Damaser Margot S
Delivery
Female
Female pelvic medicine & reconstructive surgery
Humans
Knockout
Kuang Mei
Lenis Andrew T
Mice
Models
Obstetric/*adverse effects/methods
Pelvic Organ Prolapse/*genetics/metabolism/pathology
Penn Marc S
Pregnancy
Reverse Transcriptase Polymerase Chain Reaction
Urethra/metabolism
Urinary Bladder/metabolism
Vagina/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/ACM.0b013e31826b8498" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/ACM.0b013e31826b8498</a>
Pages
1600–1608
Issue
11
Volume
87
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The scope and variety of combined baccalaureate-MD programs in the United States.
Publisher
An entity responsible for making the resource available
Academic medicine : journal of the Association of American Medical Colleges
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
*Curriculum; *Faculty; Achievement; Cultural Diversity; Education; Educational; Humans; Medical; Models; Premedical/*methods; School Admission Criteria; Schools; Undergraduate/*methods; United States
Creator
An entity primarily responsible for making the resource
Eaglen Robert H; Arnold Louise; Girotti Jorge A; Cosgrove Ellen M; Green Marianne M; Kollisch Donald O; McBeth Dani L; Penn Mark A; Tracy Sarah W
Description
An account of the resource
The landscape of combined baccalaureate-MD programs has changed substantially in the last two decades but has not been documented in detail. The authors review the current state of these programs and discuss opportunities for future study of their evolving role and potential impact.In 2011, using a definition of baccalaureate-MD program built on prior research, the authors reviewed Association of American Medical Colleges sources and medical school Web sites to identify and characterize 81 active programs. In addition, they surveyed the 57 medical schools offering those programs; 31 schools with 39 programs responded. The resulting database inventories the number and distribution of programs; institutional affiliations; missions or goals; length; size; admissions criteria; curricula; and retention requirements.Since the inception of combined programs in 1961, their number and curricular length have increased. Pressures that spurred earlier programs remain evident in the goals of today's programs: attract talented high school or early college students, especially from diverse backgrounds; prepare physicians to meet societal needs; and offer an enriched premedical environment. Baccalaureate educational activities achieve program goals through special courses, medical experiences, community service, and learning communities tailored to students' needs. Admission and retention criteria are comparable to those of traditional medical schools.Combined baccalaureate-MD programs have evolved along several paths during the last half century and have enriched the baccalaureate experiences of medical students. Shifting expectations for the selection and education of future physicians warrant focused research on these programs to document their effectiveness in addressing those expectations.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/ACM.0b013e31826b8498" target="_blank" rel="noreferrer noopener">10.1097/ACM.0b013e31826b8498</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Curriculum
*Faculty
2012
Academic medicine : journal of the Association of American Medical Colleges
Achievement
Arnold Louise
Cosgrove Ellen M
Cultural Diversity
Eaglen Robert H
Education
Educational
Girotti Jorge A
Green Marianne M
Humans
Kollisch Donald O
McBeth Dani L
Medical
Models
Penn Mark A
Premedical/*methods
School Admission Criteria
Schools
Tracy Sarah W
Undergraduate/*methods
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/ACM.0b013e3181ba9946" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/ACM.0b013e3181ba9946</a>
Pages
1500–1504
Issue
11
Volume
84
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Perspective: A perfect storm: the convergence of bullet points, competencies, and screen reading in medical education.
Publisher
An entity responsible for making the resource available
Academic medicine : journal of the Association of American Medical Colleges
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-11
Subject
The topic of the resource
*Curriculum; *Professional Competence; *Software; *Teaching; Attention; Cognition; Education; Educational; Humans; Medical/*methods; Models; Physician's Role; Reading
Creator
An entity primarily responsible for making the resource
Wear Delese
Description
An account of the resource
Three distinct phenomena are currently at play in medical education: (1) the pervasive use of PowerPoint in teaching, (2) the wholesale application of competency models, and (3) the shift from paper reading to screen reading regardless of course, text, or genre. Finding themselves placed at this intersection, students encounter fewer and fewer opportunities to practice some of the very cognitive and affective habits medical educators say they value in physicians, particularly critical reflection and deliberation, an eye for nuance, context, and ambiguity, and an appreciation that becoming a doctor involves more than learning content or performing skills. This article confronts these phenomena singly and then at their intersection, which may discourage, even dismantle, many of these habits. The author proposes that the rapid shift over the past decade to a technology-driven, competency-oriented environment in medical education is the medical educators' creation, one that sets up conditions for a perfect cognitive storm.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/ACM.0b013e3181ba9946" target="_blank" rel="noreferrer noopener">10.1097/ACM.0b013e3181ba9946</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Curriculum
*Professional Competence
*Software
*Teaching
2009
Academic medicine : journal of the Association of American Medical Colleges
Attention
Cognition
Department of Family & Community Medicine
Education
Educational
Humans
Medical/*methods
Models
NEOMED College of Medicine
Physician's Role
Reading
Wear Delese
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00001888-199809000-00011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00001888-199809000-00011</a>
Pages
943–947
Issue
9
Volume
73
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Understanding the costs of ambulatory care training.
Publisher
An entity responsible for making the resource available
Academic medicine : journal of the Association of American Medical Colleges
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-09
Subject
The topic of the resource
*Ambulatory Care; Costs and Cost Analysis; Education; Faculty; Graduate/*economics; Medical; Models; Theoretical; United States
Creator
An entity primarily responsible for making the resource
Boex J R; Blacklow R; Boll A; Fishman L; Gamliel S; Garg M; Gilchrist V; Hogan A; Meservey P; Pearson S; Politzer R; Veloski J J
Description
An account of the resource
While patient care has been shifting to the ambulatory setting, the education of health care professionals has remained essentially hospital-based. One factor discouraging the movement of training into community-based ambulatory settings is the lack of understanding of what the costs of such training are and how these costs might be offset. The authors describe a model for ambulatory care training that makes it easier to generalize about to quantify its educational costs. Since ambulatory care training does not exist in a vacuum separate from inpatient education, the model is compatible with the way hospital-based education costs are derived. Thus, the model's elements can be integrated with comparable hospital-based training cost elements in a straightforward way to allow a total-costing approach. The model is built around two major sets of variables affecting cost. The first comprises three types of costs–direct, indirect, and infrastructure–and the second consists of factors related to the training site and factors related to the educational activities of the training. The model is constructed to show the various major ways these two sets of variables can influence training costs. With direct Medicare funding for some ambulatory-setting-based education pending, and with other regulatory and market dynamics already in play, it is important that educators, managers, and policymakers understand how costs, the characteristics of the training, and the characteristics of the setting interact. This model should assist them. Without generalizable cost estimates, realistic reimbursement policies and financial incentives cannot be formulated, either in the broad public policy context or in simple direct negotiations between sites and sponsors.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00001888-199809000-00011" target="_blank" rel="noreferrer noopener">10.1097/00001888-199809000-00011</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ambulatory Care
1998
Academic medicine : journal of the Association of American Medical Colleges
Blacklow R
Boex J R
Boll A
Costs and Cost Analysis
Department of Family & Community Medicine
Education
Faculty
Fishman L
Gamliel S
Garg M
Gilchrist V
Graduate/*economics
Hogan A
Medical
Meservey P
Models
NEOMED College of Medicine
Pearson S
Politzer R
Theoretical
United States
Veloski J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00001888-199712000-00015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00001888-199712000-00015</a>
Pages
1056–1062
Issue
12
Volume
72
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Professional development of medical students: problems and promises.
Publisher
An entity responsible for making the resource available
Academic medicine : journal of the Association of American Medical Colleges
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-12
Subject
The topic of the resource
*Character; *Education; *Professional Practice; Cultural Diversity; Feminism; Humans; Knowledge; Medical; Medical/*psychology; Models; Students; Theoretical; United States
Creator
An entity primarily responsible for making the resource
Wear D
Description
An account of the resource
Observers and critics of the medical profession, both within and without, urge that more attention be paid to the moral sensibilities, the characters, of medical students. Passing on particular moral values and actions to physicians has always been an essential core of medical training, and this call for renewal is not new in modern medicine. Some of the structures and characteristics of modern medical education, however, often work directly against the professionalism that the education espouses. For example, medical students are socialized into a hierarchy that has broad implications for relations among health care professionals, other health care workers, and patients, and academic medicine has not promoted and taught critical reflection about the values and consequences of this hierarchy. Further, behind the formal curriculum lies the "hidden curriculum" of values that are unconsciously or half-consciously passed on from the faculty and older trainees. Two resources for thinking anew about professional development for medical students are feminist standpoint theory and critical multicultural theory, each of which raises important and fundamental questions about defining the role of medicine in society and the role of the physician in medicine. The author discusses these two theories and their implications for medical education, showing how they can be used to move discussions of professional development into analysis of the widespread social consequences of how a society organizes its health care and into critical reflection on the nature of medical knowledge.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00001888-199712000-00015" target="_blank" rel="noreferrer noopener">10.1097/00001888-199712000-00015</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Character
*Education
*Professional Practice
1997
Academic medicine : journal of the Association of American Medical Colleges
Cultural Diversity
Department of Family & Community Medicine
Feminism
Humans
Knowledge
Medical
Medical/*psychology
Models
NEOMED College of Medicine
Students
Theoretical
United States
Wear D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/10408398.2014.982243" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/10408398.2014.982243</a>
Pages
1753–1775
Issue
10
Volume
56
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.
Publisher
An entity responsible for making the resource available
Critical reviews in food science and nutrition
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-07
Subject
The topic of the resource
aerodigestive and gastrointestinal tract; Animal; Animal Studies; Animals; Anthocyanins/analysis/pharmacology; Anticarcinogenic Agents/*analysis/pharmacology; Antineoplastic Agents – Analysis; Antineoplastic Agents – Pharmacodynamics; Benzopyrans – Analysis; Benzopyrans – Pharmacodynamics; Berry; Biological; cancer; chemoprevention; Clinical Trials; Clinical Trials as Topic; Digestion – Drug Effects; Digestion/drug effects; Disease Models; Ellagic Acid/analysis/pharmacology; Fruit; Fruit/*chemistry; Gastrointestinal Neoplasms – Prevention and Control; Gastrointestinal Neoplasms/*prevention & control; Human; Humans; Models; Phytochemicals – Analysis; Phytochemicals – Pharmacodynamics; Phytochemicals/analysis/pharmacology; Plant Extracts – Analysis; Plant Extracts – Pharmacodynamics; Plant Extracts/*analysis/pharmacology; Polyphenols – Analysis; Polyphenols – Pharmacodynamics; Polyphenols/analysis/pharmacology; treatment
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Haskell Yennie; Do Chau; Siveen Kodappully Sivaraman; Mohandas Nima; Sethi Gautam; Stoner Gary D
Description
An account of the resource
Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/10408398.2014.982243" target="_blank" rel="noreferrer noopener">10.1080/10408398.2014.982243</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
aerodigestive and gastrointestinal tract
Animal
Animal Studies
Animals
Anthocyanins/analysis/pharmacology
Anticarcinogenic Agents/*analysis/pharmacology
Antineoplastic Agents – Analysis
Antineoplastic Agents – Pharmacodynamics
Benzopyrans – Analysis
Benzopyrans – Pharmacodynamics
Berry
Biological
Bishayee Anupam
Cancer
Chemoprevention
Clinical Trials
Clinical Trials as Topic
Critical reviews in food science and nutrition
Digestion – Drug Effects
Digestion/drug effects
Disease Models
Do Chau
Ellagic Acid/analysis/pharmacology
Fruit
Fruit/*chemistry
Gastrointestinal Neoplasms – Prevention and Control
Gastrointestinal Neoplasms/*prevention & control
Haskell Yennie
Human
Humans
Models
Mohandas Nima
Phytochemicals – Analysis
Phytochemicals – Pharmacodynamics
Phytochemicals/analysis/pharmacology
Plant Extracts – Analysis
Plant Extracts – Pharmacodynamics
Plant Extracts/*analysis/pharmacology
Polyphenols – Analysis
Polyphenols – Pharmacodynamics
Polyphenols/analysis/pharmacology
Sethi Gautam
Siveen Kodappully Sivaraman
Stoner Gary D
Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/10401334.2012.715255" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/10401334.2012.715255</a>
Pages
309–314
Issue
4
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mindfulness as a predictor of positive reappraisal and burnout in standardized patients.
Publisher
An entity responsible for making the resource available
Teaching and learning in medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012
Subject
The topic of the resource
*Adaptation; *Emotions; *Patient Satisfaction; 80 and over; Adult; Aged; Burnout; Clinical Assessment Tools; Coefficient Alpha; Convenience Sample; Descriptive Statistics; Education; Female; Human; Humans; Job Characteristics; Male; Medical; Middle Aged; Mind Body Techniques; Models; Multiple Regression; Ohio; Patient Simulation; Professional – Risk Factors; Psychological; Psychological/*complications/psychology; Psychometrics; Questionnaires; Regression Analysis; Risk Assessment; Statistics as Topic; Stress; Summated Rating Scaling
Creator
An entity primarily responsible for making the resource
Gerzina Holly A; Porfeli Erik J
Description
An account of the resource
BACKGROUND: Standardized patients (SPs) portray emotionally intense roles that can have unintended deleterious effects including burnout. PURPOSE: This study explored SP characteristics that could serve as protective factors against these adverse effects. The literature suggests that positive reappraisal and mindfulness are protective factors, with positive reappraisal mediating the relationship between mindfulness and burnout. METHODS: Seventy-six SPs completed an instrument measuring burnout, positive reappraisal, and mindfulness. Multiple regression was performed to test the hypothesized mediator model. RESULTS: The results revealed that mindfulness and positive reappraisal explained a meaningful portion of SP burnout variance (R (2) = .31 p \textless .01). Germane to the mediator model, all correlations were significant: mindfulness and positive reappraisal (a) r = .668; positive reappraisal and burnout (b) r = -.527; and mindfulness and burnout (c) r = -.496, p \textless 01. When positive reappraisal and mindfulness were included in the model, the previously significant relationship c was no longer statistically significant. The combination of these three relationships supports a mediator model. CONCLUSIONS: Education to enhance mindfulness and positive reappraisal offers a way to offset the adverse effects of portraying intense emotional patient experiences.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/10401334.2012.715255" target="_blank" rel="noreferrer noopener">10.1080/10401334.2012.715255</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Adaptation
*Emotions
*Patient Satisfaction
2012
80 and over
Adult
Aged
Burnout
Clinical Assessment Tools
Coefficient Alpha
Convenience Sample
Department of Family & Community Medicine
Descriptive Statistics
Education
Female
Gerzina Holly A
Human
Humans
Job Characteristics
Male
Medical
Middle Aged
Mind Body Techniques
Models
Multiple Regression
NEOMED College of Medicine
Ohio
Patient Simulation
Porfeli Erik J
Professional – Risk Factors
Psychological
Psychological/*complications/psychology
Psychometrics
Questionnaires
Regression Analysis
Risk Assessment
Statistics as Topic
Stress
Summated Rating Scaling
Teaching and learning in medicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.M109.083899" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.M109.083899</a>
Pages
3035–3043
Issue
5
Volume
285
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.
Publisher
An entity responsible for making the resource available
The Journal of biological chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-01
Subject
The topic of the resource
Absorption; Animals; Biological; Cell Line; Cholesterol/*metabolism; Class B/*genetics/metabolism; Coronary Disease/metabolism; Cytoplasmic and Nuclear/*metabolism; Glucose/metabolism; Hepatocyte Nuclear Factor 4/metabolism; Homeostasis; Humans; Lipoproteins/metabolism; Liver/metabolism; Mice; Models; Receptors; Scavenger Receptors
Creator
An entity primarily responsible for making the resource
Zhang Yanqiao; Yin Liya; Anderson Jody; Ma Huiyan; Gonzalez Frank J; Willson Timothy M; Edwards Peter A
Description
An account of the resource
Farnesoid X receptor (FXR) plays important regulatory roles in bile acid, lipoprotein, and glucose homeostasis. Here, we have utilized Fxr(-/-) mice and mice deficient in scavenger receptor class B type I (SR-BI), together with an
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.M109.083899" target="_blank" rel="noreferrer noopener">10.1074/jbc.M109.083899</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Absorption
Anderson Jody
Animals
Biological
Cell Line
Cholesterol/*metabolism
Class B/*genetics/metabolism
Coronary Disease/metabolism
Cytoplasmic and Nuclear/*metabolism
Department of Integrative Medical Sciences
Edwards Peter A
Glucose/metabolism
Gonzalez Frank J
Hepatocyte Nuclear Factor 4/metabolism
Homeostasis
Humans
Lipoproteins/metabolism
Liver/metabolism
Ma Huiyan
Mice
Models
NEOMED College of Medicine
Receptors
Scavenger Receptors
The Journal of biological chemistry
Willson Timothy M
Yin Liya
Zhang Yanqiao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1073/pnas.170295297" target="_blank" rel="noreferrer noopener">http://doi.org/10.1073/pnas.170295297</a>
Pages
9967–9971
Issue
18
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Using O2 to probe membrane immersion depth by 19F NMR.
Publisher
An entity responsible for making the resource available
Proceedings of the National Academy of Sciences of the United States of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-08
Subject
The topic of the resource
*Hydrocarbons; *Oxygen; Biological; Cyclic N-Oxides; Dimyristoylphosphatidylcholine/*chemistry; Fluorinated; Fluorine; Lipid Bilayers/*chemistry; Magnetic Resonance Spectroscopy/*methods; Maltose/*analogs & derivatives; Models; Phospholipid Ethers/*chemistry; Pressure; Spin Labels
Creator
An entity primarily responsible for making the resource
Prosser R S; Luchette P A; Westerman P W
Description
An account of the resource
A fluorinated detergent, CF(3)(CF(2))(5)C(2)H(4)-O-maltose, was reconstituted into a lipid bilayer model membrane system to demonstrate the feasibility of determining solvent accessibility and membrane immersion depth of each fluorinated group by (19)F NMR. Apolar oxygen, which is known to partition with an increasing concentration gradient toward the hydrophobic membrane interior, exhibits a range of paramagnetic relaxation effects on (19)F nuclei, depending on its depth in the membrane. This effect, which is predominately associated with spin-lattice relaxation rates (R(1)) and chemical shifts, can be amplified greatly with minimal line broadening by increasing the partial pressure of O(2) at least 100-fold (i.e., P(O(2)) greater than 20 bar). The differences of longitudinal relaxation rates at 20 bar of oxygen pressure to those under ambient pressure (R(1)(20bar) - R(1)(0)) are largest for those fluorine groups expected to be most deeply buried in the membrane bilayer. This result contrasts with the reverse trend, which is observed on addition of a membrane surface-associated paramagnetic species, 4-(N,N-dimethyl-N-hexadecyl) ammonium-2,2,6,6-tetramethylpiperidine-1-oxyl iodide (CAT-16) at ambient pressures. Thus, differential relaxation rates may be observed in (19)F-labeled membrane-associated molecules resulting from the addition of apolar oxygen under high pressure. The results demonstrate that the degree of solvent accessibility and membrane immersion depth of specific fluorinated species in membrane-associated macromolecules can be probed by (19)F NMR.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1073/pnas.170295297" target="_blank" rel="noreferrer noopener">10.1073/pnas.170295297</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Hydrocarbons
*Oxygen
2000
Biological
Cyclic N-Oxides
Dimyristoylphosphatidylcholine/*chemistry
Fluorinated
Fluorine
Lipid Bilayers/*chemistry
Luchette P A
Magnetic Resonance Spectroscopy/*methods
Maltose/*analogs & derivatives
Models
Phospholipid Ethers/*chemistry
Pressure
Proceedings of the National Academy of Sciences of the United States of America
Prosser R S
Spin Labels
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1524-475x.2003.11208.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1524-475x.2003.11208.x</a>
Pages
127–131
Issue
2
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of vascular endothelial growth factor on wound closure rates in the genetically diabetic mouse model.
Publisher
An entity responsible for making the resource available
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-04
Subject
The topic of the resource
Administration; Angiogenesis Inducing Agents/*administration & dosage; Animal; Animals; Diabetes Mellitus/*physiopathology; Endothelial Growth Factors/*administration & dosage; Intercellular Signaling Peptides and Proteins/*administration & dosage; Lymphokines/*administration & dosage; Mice; Models; Topical; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing/*drug effects
Creator
An entity primarily responsible for making the resource
Kirchner Loren M; Meerbaum Sharon O; Gruber Brian S; Knoll Andrew K; Bulgrin Jeffery; Taylor R A J; Schmidt Steven P
Description
An account of the resource
Impaired wound healing is characteristic of diabetic patients. Potential reasons include poor inflammatory response, granulation tissue formation, and abnormal patterns of cytokine release and response. Vascular endothelial growth factor, abnormally regulated during healing in diabetics, is the major factor stimulating angiogenesis during normal wound healing. We tested our hypothesis that topically applied vascular endothelial growth factor would improve wound closure rates in diabetic animals in a full-thickness wound model in genetically diabetic mice (C57 BL/KsJ db/db). Animals received either 1.0 micro g of vascular endothelial growth factor165 or polyethylene glycol alone topically to wounds daily between days 0 and 4 post-wounding. Wound area was measured at days 0, 5, 10, 15, and 21. Data were analyzed using probit analysis and expressed as length-of-time (LT) to 50, 90, and 95% wound closure. Among untreated animals, nondiabetics had an LT50 of 8.5 days (fiducial limits 8.3-8.7), while diabetics had an LT50 of 15.8 days (15.6-16.1). Vascular endothelial growth factor-treated animals had LT50 values of 7.8 (7.6-8.1) and 11.8 days (11.6-12.0) for nondiabetics and diabetics, respectively, representing a 25% improvement in time to 50% closure in treated diabetics. We conclude that topically applied vascular endothelial growth factor improves time to wound closure in the genetically diabetic mouse model.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1524-475x.2003.11208.x" target="_blank" rel="noreferrer noopener">10.1046/j.1524-475x.2003.11208.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Administration
Angiogenesis Inducing Agents/*administration & dosage
Animal
Animals
Bulgrin Jeffery
College of Graduate Studies
Department of Pharmaceutical Sciences
Diabetes Mellitus/*physiopathology
Endothelial Growth Factors/*administration & dosage
Gruber Brian S
Intercellular Signaling Peptides and Proteins/*administration & dosage
Kirchner Loren M
Knoll Andrew K
Lymphokines/*administration & dosage
Meerbaum Sharon O
Mice
Models
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Schmidt Steven P
Taylor R A J
Topical
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Wound Healing/*drug effects
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1037/a0032597" target="_blank" rel="noreferrer noopener">http://doi.org/10.1037/a0032597</a>
Pages
458–463
Issue
3
Volume
50
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Clinical process examples of cognitive behavioral therapy for psychosis.
Publisher
An entity responsible for making the resource available
Psychotherapy (Chicago, Ill.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-09
Subject
The topic of the resource
*Psychotherapeutic Processes; Adult; Cognitive Behavioral Therapy/*methods; Cognitive Therapy – Methods; Cooperative Behavior; Culture; Defense Mechanisms; Delusions – Psychosocial Factors; Delusions – Therapy; Delusions/psychology/therapy; Female; Hallucinations – Psychosocial Factors; Hallucinations – Therapy; Hallucinations/psychology/therapy; Humans; Internal-External Control; Locus of Control; Male; Middle Age; Middle Aged; Models; Paranoid Disorders – Psychosocial Factors; Paranoid Disorders – Therapy; Paranoid Disorders/psychology/therapy; Psychological; Psychology; Psychotherapeutic Processes; Psychotic Disorders – Psychosocial Factors; Psychotic Disorders – Therapy; Psychotic Disorders/psychology/*therapy; Schizophrenia – Therapy; Schizophrenia/therapy; Schizophrenic Psychology
Creator
An entity primarily responsible for making the resource
Sivec Harry J; Montesano Vicki L
Description
An account of the resource
Interest in the practice of Cognitive Behavioral Therapy for persistent psychotic symptoms (CBT-p) has increased dramatically in the last decade. Despite the widespread interest, it remains challenging to obtain adequate training in this approach in the United States. This article provides a few hypothetical examples of the types of interventions commonly used in CBT-p. We provide information about the theoretical basis for the techniques and related research support. We also provide references that offer more detailed discussion of the theory and application of the techniques.
Identifier
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<a href="http://doi.org/10.1037/a0032597" target="_blank" rel="noreferrer noopener">10.1037/a0032597</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Psychotherapeutic Processes
2013
Adult
Cognitive Behavioral Therapy/*methods
Cognitive Therapy – Methods
Cooperative Behavior
Culture
Defense Mechanisms
Delusions – Psychosocial Factors
Delusions – Therapy
Delusions/psychology/therapy
Female
Hallucinations – Psychosocial Factors
Hallucinations – Therapy
Hallucinations/psychology/therapy
Humans
Internal-External Control
Locus of Control
Male
Middle Age
Middle Aged
Models
Montesano Vicki L
Paranoid Disorders – Psychosocial Factors
Paranoid Disorders – Therapy
Paranoid Disorders/psychology/therapy
Psychological
Psychology
Psychotherapeutic Processes
Psychotherapy (Chicago, Ill.)
Psychotic Disorders – Psychosocial Factors
Psychotic Disorders – Therapy
Psychotic Disorders/psychology/*therapy
Schizophrenia – Therapy
Schizophrenia/therapy
Schizophrenic Psychology
Sivec Harry J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s1070-3241(16)30402-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s1070-3241(16)30402-3</a>
Pages
541–548
Issue
10
Volume
24
Dublin Core
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Title
A name given to the resource
Hospital participation in community partnerships to improve health.
Publisher
An entity responsible for making the resource available
The Joint Commission journal on quality improvement
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-10
Subject
The topic of the resource
*Community-Institutional Relations; *Hospital Administration; Boston; Chicago; Community Health Planning/*organization & administration; Cooperative Behavior; Economic Competition; Humans; Marketing of Health Services; Models; Ohio; Organizational; Organizational Case Studies; Total Quality Management/*organization & administration
Creator
An entity primarily responsible for making the resource
Boex J R; Cooksey J; Inui T
Description
An account of the resource
BACKGROUND: The core business of hospitals now requires, for both competitiveness and quality improvement reasons, that hospitals move beyond their physical and conceptual walls to form community partnerships. THE HOSPITAL'S ROLE AS A PARTNER IN COMMUNITY-BASED HEALTH IMPROVEMENT SYSTEMS: Hospitals, as organizations that are significant health care, social, and economic institutions in their communities, should play a leading role in mobilizing resources for such community-level health improvement efforts. MOVING OUTSIDE THE WALLS TO IMPROVE QUALITY: Three examples of extending hospital efforts into the community demonstrate that improvement of a problem involving hospital care can derive from a collaborative, community-based activity. In Boston, infection control–once a standard, strictly in-house procedure–has been forced by altered patterns of hospital use to become a largely community-based process. In Chicago, a variety of health care providers and community representatives have worked effectively to reduce mortality and morbidity in a single disease (asthma) model. In Akron, Ohio, Lifelink program hospitals, working together with community agencies and groups in a door-to-door neighborhood program, improved the effectiveness of prenatal care and the quality of birth outcomes. CONCLUSION: Efforts to work with community groups to improve health status should not be simply an optional do-good endeavor, as they have often been in the past, but rather an essential part of quality improvement and good business practice. Marketplace incentives will increasingly reward hospitals that are able to form successful community partnerships.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s1070-3241(16)30402-3" target="_blank" rel="noreferrer noopener">10.1016/s1070-3241(16)30402-3</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Community-Institutional Relations
*Hospital Administration
1998
Boex J R
Boston
Chicago
Community Health Planning/*organization & administration
Cooksey J
Cooperative Behavior
Department of Family & Community Medicine
Economic Competition
Humans
Inui T
Marketing of Health Services
Models
NEOMED College of Medicine
Ohio
Organizational
Organizational Case Studies
The Joint Commission journal on quality improvement
Total Quality Management/*organization & administration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0028-3932(98)00061-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0028-3932(98)00061-x</a>
Pages
1077–1082
Issue
10
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sperry's concept of mind as an emergent property of brain function and its implications for the future of humankind.
Publisher
An entity responsible for making the resource available
Neuropsychologia
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-10
Subject
The topic of the resource
*Forecasting; *Humanism; *Psychophysiology; Biological; Brain/physiology; Conscience; Humans; Models; Psychology/trends
Creator
An entity primarily responsible for making the resource
Voneida T J
Description
An account of the resource
Sperry's proposal that subjective experience plays a major role in brain function and in the emergence of mind, consciousness and human values represent a challenge to behaviorism as the dominant force in psychology. Mind is viewed as an emergent property of the brain, generated from and dependent upon neural activity, but nonetheless separate from it. Macrodeterministic factors result in the evolution of human values, which represent a critical key to world change. Two major conferences resulted from Sperry's challenge to the scientific community. The Trieste Conference led to a 'Declaration of Human Responsibilities', presently under consideration by the United Nations as a corollary to the 'Declaration of Human Rights'. The Japan Conference inspired work toward a Network University of the Green World, in which computer networking will support international communication in areas of environmental concern.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0028-3932(98)00061-x" target="_blank" rel="noreferrer noopener">10.1016/s0028-3932(98)00061-x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Forecasting
*Humanism
*Psychophysiology
1998
Biological
Brain/physiology
Conscience
Humans
Models
Neuropsychologia
Psychology/trends
Voneida T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.yjmcc.2009.06.017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.yjmcc.2009.06.017</a>
Pages
530–537
Issue
3
Volume
48
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Non-fibrillar collagens: key mediators of post-infarction cardiac remodeling?
Publisher
An entity responsible for making the resource available
Journal of molecular and cellular cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-03
Subject
The topic of the resource
Animals; Biological; Humans; Matrix Metalloproteinases/metabolism; Models; Myocardial Infarction/*metabolism/physiopathology; Myocardium/metabolism/pathology; Non-Fibrillar Collagens/*metabolism; Wound Healing/physiology
Creator
An entity primarily responsible for making the resource
Shamhart Patricia E; Meszaros J Gary
Description
An account of the resource
Cardiac remodeling is accelerated during pathological conditions and several anabolic and catabolic regulators work in concert to repair the myocardium and maintain its functionality. The fibroblasts play a major role in this process via collagen deposition as well as supplying the degradative matrix metalloproteinases. During the more acute responses to a myocardial infarction (MI) the heart relies on a more aggressive wound healing sequence that includes the myofibroblasts, specialized secretory cells necessary for infarct scar formation and thus, rescue of the myocardium. The activated fibroblasts and myofibroblasts deposit large amounts of fibrillar collagen during the post-MI wound healing phase, type I and III collagen are the most abundant collagens in the heart and they maintain the structural integrity under normal and disease states. While collagen I and III have been the traditional focus of the myocardial matrix, recent studies have suggested that the non-fibrillar collagens (types IV and VI) are also deposited during pathological wound healing and may play key roles in myofibroblast differentiation and organization of the fibrillar collagen network. This review highlights the potential roles of the non-fibrillar collagens and how they work in concert with the fibrillar collagens in mediating myocardial remodeling.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.yjmcc.2009.06.017" target="_blank" rel="noreferrer noopener">10.1016/j.yjmcc.2009.06.017</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Animals
Biological
Department of Integrative Medical Sciences
Humans
Journal of molecular and cellular cardiology
Matrix Metalloproteinases/metabolism
Meszaros J Gary
Models
Myocardial Infarction/*metabolism/physiopathology
Myocardium/metabolism/pathology
NEOMED College of Medicine
Non-Fibrillar Collagens/*metabolism
Shamhart Patricia E
Wound Healing/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.semcdb.2006.03.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.semcdb.2006.03.003</a>
Pages
334–344
Issue
3
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins).
Publisher
An entity responsible for making the resource available
Seminars in cell & developmental biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-06
Subject
The topic of the resource
*Signal Transduction; Animals; Biological; G-Protein-Coupled/*metabolism; Heterotrimeric GTP-Binding Proteins/*metabolism; Humans; Models; Receptors
Creator
An entity primarily responsible for making the resource
Cismowski Mary J
Description
An account of the resource
G-protein coupled receptor (GPCR) signaling represents one of the most conserved and ubiquitous means in mammalian cells for transferring information across the plasma membrane to the intracellular environment. Heterotrimeric G-protein subunits play key roles in transducing these signals, and intracellular regulators influencing the activation state and interaction of these subunits regulate the extent and duration of GPCR signaling. One class of intracellular regulator, the non-receptor activators of G-protein signaling (or AGS proteins), are the major focus of this review. AGS proteins provide a basis for understanding the function of heterotrimeric G-proteins in both GPCR-driven and GPCR independent cellular signaling pathways.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.semcdb.2006.03.003" target="_blank" rel="noreferrer noopener">10.1016/j.semcdb.2006.03.003</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Signal Transduction
2006
Animals
Biological
Cismowski Mary J
G-Protein-Coupled/*metabolism
Heterotrimeric GTP-Binding Proteins/*metabolism
Humans
Models
Receptors
Seminars in cell & developmental biology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neubiorev.2010.12.015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neubiorev.2010.12.015</a>
Pages
2073–2083
Issue
10
Volume
35
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Neural processing of target distance by echolocating bats: functional roles of the auditory midbrain.
Publisher
An entity responsible for making the resource available
Neuroscience and biobehavioral reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Animals; Auditory Cortex/physiology; Auditory Pathways/*physiology; Auditory Perception/*physiology; Brain Mapping/psychology; Chiroptera/*physiology; Echolocation/*physiology; Inferior Colliculi/*physiology; Models; Neurological; Neurons/physiology
Creator
An entity primarily responsible for making the resource
Wenstrup Jeffrey J; Portfors Christine V
Description
An account of the resource
Using their biological sonar, bats estimate distance to avoid obstacles and capture moving prey. The primary distance cue is the delay between the bat's emitted echolocation pulse and the return of an echo. The mustached bat's auditory midbrain (inferior colliculus, IC) is crucial to the analysis of pulse-echo delay. IC neurons are selective for certain delays between frequency modulated (FM) elements of the pulse and echo. One role of the IC is to create these "delay-tuned", "FM-FM" response properties through a series of spectro-temporal integrative interactions. A second major role of the midbrain is to project target distance information to many parts of the brain. Pathways through auditory thalamus undergo radical reorganization to create highly ordered maps of pulse-echo delay in auditory cortex, likely contributing to perceptual features of target distance analysis. FM-FM neurons in IC also project strongly to pre-motor centers including the pretectum and the pontine nuclei. These pathways may contribute to rapid adjustments in flight, body position, and sonar vocalizations that occur as a bat closes in on a target.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neubiorev.2010.12.015" target="_blank" rel="noreferrer noopener">10.1016/j.neubiorev.2010.12.015</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Auditory Cortex/physiology
Auditory Pathways/*physiology
Auditory Perception/*physiology
Brain Mapping/psychology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/*physiology
Inferior Colliculi/*physiology
Models
NEOMED College of Medicine
Neurological
Neurons/physiology
Neuroscience and biobehavioral reviews
Portfors Christine V
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jpainsymman.2011.03.023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jpainsymman.2011.03.023</a>
Pages
10–19
Issue
1
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Professional judgments about advance care planning with community-dwelling consumers.
Publisher
An entity responsible for making the resource available
Journal of pain and symptom management
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
*Attitude of Health Personnel; *Decision Making; *Health Care Surveys; Advance Care Planning; Advance Care Planning/organization & administration/*statistics & numerical data; Attitude of Health Personnel; Consumer Behavior/*statistics & numerical data; Consumer Satisfaction – Statistics and Numerical Data; Decision Making; Human; Humans; Management; Midwestern United States; Models; Organizational; Patient Satisfaction – Statistics and Numerical Data; Patient Satisfaction/*statistics & numerical data; Population Surveillance; Questionnaires; Randomized Controlled Trials; Surveys; Surveys and Questionnaires
Creator
An entity primarily responsible for making the resource
Baughman Kristin R; Ludwick Ruth E; Merolla David M; Palmisano Barbara; Hazelett Susan; Winchell Janice; Hewit Michael
Description
An account of the resource
CONTEXT: There is limited research on how community-based long-term care (CBLTC) providers' personal characteristics and attitudes affect their decisions to initiate advance care planning (ACP) conversations with consumers. OBJECTIVES: To examine judgments by CBLTC providers as to whether a consumer was in need of ACP and to compare the relative influence of situational features of the consumer with the influence of personal characteristics of the CBLTC provider. METHODS: Factorial surveys with vignettes with randomly assigned situational features of a hypothetical consumer were obtained from 182 CBLTC providers at three Area Agencies on Aging located in the Midwestern U.S. Measures included the consumer's situational features, such as demographics, diagnosis, pain level, level of functioning, and caregiver involvement. Personal characteristics of the CBLTC provider included demographics, discipline, past experience with ACP, and attitudes toward ACP. RESULTS: Hierarchical linear models indicated that most variability in ACP decisions was the result of differences among CBLTC providers (64%) rather than consumers' situational features. Positive decisions to discuss ACP were associated with consumers who needed assistance with legal issues and had a cancer diagnosis; these variables explained 8% of the vignette level variance. Significant personal characteristics of the CBLTC provider included a nursing background, less direct contact with consumers, past experience with ACP, and positive attitudes toward ACP; these variables explained 41% of the person-level variance. CONCLUSION: This study shows the lack of normative consensus about ACP and highlights the need for consistent educational programs regarding the role of the CBLTC provider in the ACP process.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jpainsymman.2011.03.023" target="_blank" rel="noreferrer noopener">10.1016/j.jpainsymman.2011.03.023</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Attitude of Health Personnel
*Decision Making
*Health Care Surveys
2012
advance care planning
Advance Care Planning/organization & administration/*statistics & numerical data
Attitude of Health Personnel
Baughman Kristin R
Consumer Behavior/*statistics & numerical data
Consumer Satisfaction – Statistics and Numerical Data
Decision Making
Department of Family & Community Medicine
Hazelett Susan
Hewit Michael
Human
Humans
Journal of pain and symptom management
Ludwick Ruth E
Management
Merolla David M
Midwestern United States
Models
NEOMED College of Medicine
Organizational
Palmisano Barbara
Patient Satisfaction – Statistics and Numerical Data
Patient Satisfaction/*statistics & numerical data
Population Surveillance
Questionnaires
RANDOMIZED controlled trials
Surveys
Surveys and Questionnaires
Winchell Janice
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jhevol.2012.01.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jhevol.2012.01.003</a>
Pages
473–485
Issue
4
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ontogeny of limb force distribution in squirrel monkeys (Saimiri boliviensis): insights into the mechanical bases of primate hind limb dominance.
Publisher
An entity responsible for making the resource available
Journal of human evolution
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-04
Subject
The topic of the resource
*Locomotion; Age Factors; Animals; Biological; Biomechanical Phenomena; Female; Leg/anatomy & histology/*growth & development/*physiology; Models; Saimiri/anatomy & histology/*growth & development/*physiology; Videotape Recording; Weight-Bearing
Creator
An entity primarily responsible for making the resource
Young Jesse W
Description
An account of the resource
The distribution of peak vertical forces between the forelimbs and the hind limbs is one of the key traits distinguishing primate quadrupedal locomotion from that of other mammals. Whereas most mammals generate greater peak vertical forelimb forces, primates generate greater peak vertical hind limb forces. At the ultimate level, hind limb dominance in limb force distribution is typically interpreted as an adaptation to facilitate fine-branch arboreality. However, the proximate biomechanical bases for primate limb force distribution remain controversial. Three models have been previously proposed. The Center of Mass (COM) Position model attributes primates' unique mode of limb loading to differences in the position of the whole-body COM relative to the hands and feet. The Active Weight Shift model asserts that primates actively redistribute body weight to their hind limbs by pitching the trunk up via the activation of hind limb retractor muscles. Finally, the Limb Compliance model argues that primates selectively mitigate forelimb forces by maintaining a compliant forelimb and a flat shoulder trajectory. Here, a detailed dataset of ontogenetic changes in morphology and locomotor mechanics in Bolivian squirrel monkeys (Saimiri boliviensis) was employed as a model system to evaluate each of these proposed models in turn. Over the first 10 months of life, squirrel monkeys transitioned from forelimb dominant infants to hind limb dominant juveniles, a change that was precipitated by decreases in peak vertical forelimb forces and increases in peak vertical hind limb forces. Results provided some support for all three of the models, although the COM Position and Active Weight Shift models were most strongly supported by the data. Overall, this study suggests that primates may use a variety of biomechanical strategies to achieve hind limb dominance in limb force distribution.
Identifier
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<a href="http://doi.org/10.1016/j.jhevol.2012.01.003" target="_blank" rel="noreferrer noopener">10.1016/j.jhevol.2012.01.003</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*locomotion
2012
Age Factors
Animals
Biological
Biomechanical Phenomena
Department of Anatomy & Neurobiology
Female
Journal of human evolution
Leg/anatomy & histology/*growth & development/*physiology
Models
NEOMED College of Medicine
Saimiri/anatomy & histology/*growth & development/*physiology
Videotape Recording
Weight-Bearing
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jcrc.2016.09.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jcrc.2016.09.011</a>
Pages
126–129
Volume
37
Dublin Core
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Title
A name given to the resource
Hematologic counts as predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
Publisher
An entity responsible for making the resource available
Journal of critical care
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-02
Subject
The topic of the resource
*Blood Cell Count; *Inflammation; *Intracranial vasospasm; *Subarachnoid hemorrhage; *Transcranial Doppler sonography; Anemia/blood/diagnosis; Brain Ischemia/blood/complications/*diagnosis/epidemiology; Cerebrovascular Circulation/physiology; Critical Care; Databases; Doppler; Factual; Female; Humans; Leukocytosis/blood/diagnosis; Logistic Models; Male; Middle Aged; Models; Odds Ratio; Ohio/epidemiology; Sensitivity and Specificity; Subarachnoid Hemorrhage/*complications/diagnostic imaging; Theoretical; Transcranial; Ultrasonography
Creator
An entity primarily responsible for making the resource
Da Silva Ivan Rocha Ferreira; Gomes Joao Antonio; Wachsman Ari; de Freitas Gabriel Rodriguez; Provencio Jose Javier
Description
An account of the resource
PURPOSE: Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality, but currently no single clinical method or ancillary test can reliably predict which subset of patients will develop delayed cerebral ischemia (DCI). The aim of this study was to find hematologic derangements and clinical factors present during the first 7 days after bleeding that could help identify patients at risk for development of DCI. MATERIALS AND METHODS: Databank analysis of patients with SAH admitted between 2010 and 2012 in a single center. Data from demographics, imaging, laboratory, and clinical factors were collected. Statistical testing was conducted to test for association to the outcome, and multivariate logistic regression was used to design a predictive model. RESULTS: Of 55 patients, 14 developed DCI (25%). Anemia and leukocytosis on the third day after bleeding were significantly correlated with the outcome (for anemia: P\textless.032; confidence interval, 1.12-15.16; odds ratio, 4.12; for leukocytosis: P\textless.046; confidence interval, 1.03-26.13; odds ratio, 5.18). Anemia and leukocytosis were still statistically significant after adjustment for age, sex, modified Fisher scale, and Hunt-Hess scale. CONCLUSION: The presence of leukocytosis and anemia during the third day after SAH was statistically correlated with the occurrence of DCI.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jcrc.2016.09.011" target="_blank" rel="noreferrer noopener">10.1016/j.jcrc.2016.09.011</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Blood Cell Count
*Inflammation
*Intracranial vasospasm
*Subarachnoid hemorrhage
*Transcranial Doppler sonography
2017
Anemia/blood/diagnosis
Brain Ischemia/blood/complications/*diagnosis/epidemiology
Cerebrovascular Circulation/physiology
Critical Care
Da Silva Ivan Rocha Ferreira
Databases
de Freitas Gabriel Rodriguez
Doppler
Factual
Female
Gomes Joao Antonio
Humans
Journal of critical care
Leukocytosis/blood/diagnosis
Logistic Models
Male
Middle Aged
Models
Odds Ratio
Ohio/epidemiology
Provencio Jose Javier
Sensitivity and Specificity
Subarachnoid Hemorrhage/*complications/diagnostic imaging
Theoretical
Transcranial
Ultrasonography
Wachsman Ari
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ijlp.2014.02.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ijlp.2014.02.004</a>
Pages
341–350
Issue
4
Volume
37
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Police officer perceptions of the impact of Crisis Intervention Team (CIT) programs.
Publisher
An entity responsible for making the resource available
International journal of law and psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-08
Subject
The topic of the resource
*Attitude; *Crisis Intervention; *Mentally Ill Persons; *Police; *Professional Competence; Adult; Attitude; Crisis Intervention; Crisis intervention team; Familiarity with mental illness; Female; Human; Humans; Law Enforcement; Male; Management; Middle Age; Middle Aged; Models; Officer confidence; Organizational; Police; Professional Competence; Psychiatric Patients; Social Control
Creator
An entity primarily responsible for making the resource
Bonfine Natalie; Ritter Christian; Munetz Mark R
Description
An account of the resource
The Crisis Intervention Team (CIT) program is an approach for law enforcement officers to safely response to individuals who are experiencing a mental health crisis. Research must identify the components of CIT that are instrumental to the overall effectiveness of the program. For instance, recent studies report that CIT may have a transformative effect on officers' attitudes by increasing exposure to and familiarity with mental illness. This study explores this possibility further by examining 57 CIT officers' experiences with mental illness and attitudes about CIT. Specifically, we assessed how personal and professional exposure to mental illness associates with officers' perceptions about CIT generally, as well as with opinions about the officers' confidence in their abilities and the perceived effectiveness of the police department in responding to individuals in mental health crisis. Our findings indicate that CIT is rated very positively by officers. We found that officers' attitudes about the impact of CIT on improving overall safety, accessibility of services, officer skills and techniques, and the preparedness of officers to handle calls involving persons with mental illness are positively associated with officers' confidence in their abilities or with officers' perceptions of overall departmental effectiveness. There is further evidence that personal contact with individuals with mental illness affects the relationship between attitudes that CIT impacts overall safety and perceived departmental effectiveness. The results of this exploratory study underscore the importance of CIT officers' perceptions of key elements of CIT and the role of exposure to mental illness in examining program effectiveness.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ijlp.2014.02.004" target="_blank" rel="noreferrer noopener">10.1016/j.ijlp.2014.02.004</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Attitude
*Crisis Intervention
*Mentally Ill Persons
*Police
*Professional Competence
2014
Adult
Attitude
Bonfine Natalie
College of Graduate Studies
Crisis Intervention
Crisis intervention team
Department of Family & Community Medicine
Department of Psychiatry
Familiarity with mental illness
Female
Human
Humans
International journal of law and psychiatry
Law Enforcement
Male
Management
Middle Age
Middle Aged
Models
Munetz Mark R
NEOMED College of Graduate Studies
NEOMED College of Medicine
Officer confidence
Organizational
Police
Professional Competence
Psychiatric Patients
Ritter Christian
Social Control
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2016.06.006</a>
Pages
80–93
Volume
339
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-09
Subject
The topic of the resource
*Audiometric functions; *Hearing loss; *Mouse; *Permanent threshold shift; *Sound exposure; *Temporary threshold shift; Acoustic Stimulation/*methods; Animal; Animals; Audiometry; Auditory; Auditory Threshold/*physiology; Brain Stem/*physiology; Evoked Potentials; Hearing; Inbred CBA; Male; Mice; Models; Noise; Prepulse Inhibition/*physiology; Pure-Tone/*methods; Reflex; Startle/*physiology
Creator
An entity primarily responsible for making the resource
Longenecker R J; Alghamdi F; Rosen M J; Galazyuk A V
Description
An account of the resource
The high prevalence of noise-induced and age-related hearing loss in the general population has warranted the use of animal models to study the etiology of these pathologies. Quick and accurate auditory threshold determination is a prerequisite for experimental manipulations targeting hearing loss in animal models. The standard auditory brainstem response (ABR) measurement is fairly quick and translational across species, but is limited by the need for anesthesia and a lack of perceptual assessment. The goal of this study was to develop a new method of hearing assessment utilizing prepulse inhibition (PPI) of the acoustic startle reflex, a commonly used tool that measures detection thresholds in awake animals, and can be performed on multiple animals simultaneously. We found that in control mice PPI audiometric functions are similar to both ABR and traditional operant conditioning audiograms. The hearing thresholds assessed with PPI audiometry in sound exposed mice were also similar to those detected by ABR thresholds one day after exposure. However, three months after exposure PPI threshold shifts were still evident at and near the frequency of exposure whereas ABR thresholds recovered to the pre-exposed level. In contrast, PPI audiometry and ABR wave one amplitudes detected similar losses. PPI audiometry provides a high throughput automated behavioral screening tool of hearing in awake animals. Overall, PPI audiometry and ABR assessments of the auditory system are robust techniques with distinct advantages and limitations, which when combined, can provide ample information about the functionality of the auditory system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2016.06.006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Audiometric functions
*Hearing loss
*Mouse
*Permanent threshold shift
*Sound exposure
*Temporary threshold shift
2016
Acoustic Stimulation/*methods
Alghamdi F
Animal
Animals
Audiometry
Auditory
Auditory Threshold/*physiology
Brain Stem/*physiology
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk A V
Hearing
Hearing research
Inbred CBA
Longenecker R J
Male
Mice
Models
NEOMED College of Medicine
Noise
Prepulse Inhibition/*physiology
Pure-Tone/*methods
Reflex
Rosen M J
Startle/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.freeradbiomed.2012.05.025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.freeradbiomed.2012.05.025</a>
Pages
962–973
Issue
4
Volume
53
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Protein thiyl radical mediates S-glutathionylation of complex I.
Publisher
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Free radical biology & medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
*Oxidative Stress; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Cattle; Cell Line; Cyclic N-Oxides/chemistry/pharmacology; Cysteine/chemistry/*metabolism; Electron Transport Complex I/chemistry/*metabolism; Free Radical Scavengers/chemistry/pharmacology; Free Radicals/chemistry/*metabolism; Glutathione/chemistry/*metabolism; Heart/enzymology/metabolism; Mice; Mitochondria; Models; Molecular; Molecular Sequence Data; Muscle Cells/drug effects/metabolism; Onium Compounds/pharmacology; Peptide Fragments/chemistry; Peptide Mapping; Protein; Rats; Rotenone/pharmacology; Structural Homology; Superoxides/metabolism
Creator
An entity primarily responsible for making the resource
Kang Patrick T; Zhang Liwen; Chen Chwen-Lih; Chen Jingfeng; Green Kari B; Chen Yeong-Renn
Description
An account of the resource
Complex I is a critical site of O(2)(*-) production and the major host of reactive protein thiols in mitochondria. In response to oxidative stress, complex I protein thiols at the 51- and 75-kDa subunits are reversibly
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.freeradbiomed.2012.05.025" target="_blank" rel="noreferrer noopener">10.1016/j.freeradbiomed.2012.05.025</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Oxidative Stress
2012
Amino Acid Motifs
Amino Acid Sequence
Animals
Binding Sites
Cattle
Cell Line
Chen Chwen-Lih
Chen Jingfeng
Chen Yeong-Renn
Cyclic N-Oxides/chemistry/pharmacology
Cysteine/chemistry/*metabolism
Department of Integrative Medical Sciences
Electron Transport Complex I/chemistry/*metabolism
Free radical biology & medicine
Free Radical Scavengers/chemistry/pharmacology
Free Radicals/chemistry/*metabolism
Glutathione/chemistry/*metabolism
Green Kari B
Heart/enzymology/metabolism
Kang Patrick T
Mice
Mitochondria
Models
Molecular
Molecular Sequence Data
Muscle Cells/drug effects/metabolism
NEOMED College of Medicine
Onium Compounds/pharmacology
Peptide Fragments/chemistry
Peptide Mapping
Protein
Rats
Rotenone/pharmacology
Structural Homology
Superoxides/metabolism
Zhang Liwen
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ejphar.2008.06.097" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejphar.2008.06.097</a>
Pages
1–6
Issue
1
Volume
592
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor.
Publisher
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European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-09
Subject
The topic of the resource
Amino Acid Sequence; Animals; Binding; Calcium Signaling/physiology; CHO Cells; Competitive/drug effects; Cricetinae; Cricetulus; Dose-Response Relationship; Drug; Iodine Radioisotopes; Ligands; Models; Molecular; Molecular Sequence Data; Neurokinin-1/chemistry/drug effects/*metabolism; Rats; Receptors; Substance P/chemistry/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Perrine Shane A; Beard Debbie J; Young John K; Simmons Mark A
Description
An account of the resource
Previous studies have shown that tachykinin peptide ligands of the tachykinin NK1 receptor exhibit functional selectivity with respect to signal activation and desensitization. The differences are most dramatic between the naturally occurring peptides substance P (RPKPQQFFGLM-NH2) and ranatachykinin C (HNPASFIGLM-NH2). To understand the structural features of the peptides that underlie these differences, four peptide analogs have been designed and tested. The analogs were designed to assess the major structural differences between substance P and ranatachykinin C, including the role of the N-terminal Arg and the substitution of the mid-region Glns with Ala and Ser (Q5 replaced with A and/or Q6 replaced with S). Receptor binding, receptor activation of intracellular calcium fluxes, and receptor desensitization of the rat tachykinin NK1 receptor were quantified for each ligand. All of the peptides bound to the rat tachykinin NK1 receptor with high affinity, produced robust calcium signal activation, and led to agonist-induced receptor desensitization. It was found that deletion of the N-terminal Arg of substance P or replacement of either or both Q5 and Q6 altered the functional selectivity of substance P based on the relationship of receptor binding to receptor activation and activation to desensitization. When considered in light of our previously published nuclear magnetic resonance structure data, the data presented herein suggest that the one, five and six positions of the substance P backbone are key structural residues that govern the relative degree of tachykinin peptide-mediated receptor signaling and desensitization.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejphar.2008.06.097" target="_blank" rel="noreferrer noopener">10.1016/j.ejphar.2008.06.097</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
Amino Acid Sequence
Animals
Beard Debbie J
Binding
Calcium Signaling/physiology
CHO Cells
Competitive/drug effects
Cricetinae
Cricetulus
Dose-Response Relationship
Drug
European journal of pharmacology
Iodine Radioisotopes
Ligands
Models
Molecular
Molecular Sequence Data
Neurokinin-1/chemistry/drug effects/*metabolism
Perrine Shane A
Rats
Receptors
Simmons Mark A
Substance P/chemistry/drug effects/*physiology
Young John K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cyto.2014.11.026" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cyto.2014.11.026</a>
Pages
319–325
Issue
2
Volume
73
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of type I interferons and other cytokines in dermatomyositis.
Publisher
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Cytokine
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-06
Subject
The topic of the resource
Autoantibodies/immunology; Biological; Cytokines; Dermatomyositis; Dermatomyositis/*immunology/physiopathology/therapy; Humans; Inflammatory myopathy; Interferon Type I/*metabolism; Models; Pathogenesis; Signal Transduction; Type I interferons
Creator
An entity primarily responsible for making the resource
Arshanapalli Ashish; Shah Mihir; Veerula Vindhya; Somani Ally-Khan
Description
An account of the resource
Much work has been done to unveil the mechanisms behind the pathogenesis of dermatomyositis (DM) - mainly those involving certain pathogenic cytokines, termed "pathokines" as the principal cytokines involved. Recently, it has become clear that a group of cytokines known as type I interferons (IFN-Is) play a significant role in the development of DM. We review the literature published between 1946 and 2014 using an Ovid Medline database search to provide an update on the role of IFN-Is and other cytokines in the pathogenesis of DM. We provide information about the genes and proteins induced by IFN-Is and potential mechanisms by which these downstream products relate to clinical disease activity. We also explore findings of other autoimmune phenomena that may contribute to disease onset and activity including T-helper 17 (Th17) cells and associated interleukins, as well as autoantibodies. Finally, we provide a brief update on current treatment options for DM as well as some new immunomodulatory treatment modalities in development.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cyto.2014.11.026" target="_blank" rel="noreferrer noopener">10.1016/j.cyto.2014.11.026</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Arshanapalli Ashish
Autoantibodies/immunology
Biological
Cytokine
Cytokines
Dermatomyositis
Dermatomyositis/*immunology/physiopathology/therapy
Humans
Inflammatory myopathy
Interferon Type I/*metabolism
Models
Pathogenesis
Shah Mihir
Signal Transduction
Somani Ally-Khan
Type I interferons
Veerula Vindhya