1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/mi.5.3.4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/mi.5.3.4</a>
Pages
154–157
Issue
3
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Functional selectivity, ligand-directed trafficking, conformation-specific agonism: what's in a name?
Publisher
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Molecular interventions
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-06
Subject
The topic of the resource
G-Protein-Coupled/*agonists/*chemistry; Humans; Ligands; Molecular Conformation; Protein Transport; Receptors; Signal Transduction
Creator
An entity primarily responsible for making the resource
Simmons Mark A
Description
An account of the resource
Research on the design of compounds to selectively affect specific subsets of signals downstream of receptors has burgeoned lately, and several reports discussed at Experimental Biology 2005 indicate progress is being made in the understanding of what makes a drug functionally selective. Different conformations adopted by receptors after associating with specific ligands can determine which intracellular signaling pathways get activated and which do not. The appeal of such specific compounds is enormous when one considers that many disease states might require the subtle manipulation of some (or even one) but not all downstream events stemming from specific receptor activation. Additionally, a better understanding of functional selectivity would likely improve the drug delivery process: if compounds are screened through several functional assays appropriately designed to look for compounds exhibiting a high degree of selectivity, then many potential lead compounds might not be as frequently overlooked.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/mi.5.3.4" target="_blank" rel="noreferrer noopener">10.1124/mi.5.3.4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
G-Protein-Coupled/*agonists/*chemistry
Humans
Ligands
Molecular Conformation
Molecular interventions
Protein Transport
Receptors
Signal Transduction
Simmons Mark A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0005-2736(88)90048-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0005-2736(88)90048-x</a>
Pages
64–78
Issue
1
Volume
939
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The interaction of n-alkanols with lipid bilayer membranes: a 2H-NMR study.
Publisher
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Biochimica et biophysica acta
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-03
Subject
The topic of the resource
Temperature; Molecular Conformation; Magnetic Resonance Spectroscopy; *Lipid Bilayers; *Alcohols; *Membrane Lipids; Dimyristoylphosphatidylcholine
Creator
An entity primarily responsible for making the resource
Westerman P W; Pope J M; Phonphok N; Doane J W; Dubro D W
Description
An account of the resource
The interaction of eight n-alkanols with bilayers of dimyristoylphosphatidylcholine (DMPC) has been studied by deuterium nuclear magnetic resonance (2H-NMR). At comparable temperatures and concentrations of solute in the bilayer, order parameters measured at the 1-methylene segment of the n-alkanols show a maximum for n-dodecanol. For both n-dodecanol and n-tetradecanol, orientational ordering shows a maximum at the C-4 to C-7 methylene segments, with labels at both ends of the n-alkanol exhibiting reduced order. These observations are consistent with earlier findings for n-octanol and n-decanol. Unlike the longer chain n-alkanols, ordering in n-butanol decreases from the hydroxyl group end to the methyl group end of the molecule. Orientational ordering at nine inequivalent sites in DMPC, has also been measured as a function of temperature, for bilayers containing n-butanol, n-octanol, n-dodecanol and n-tetradecanol. At the 3R,S sites on the glycerol backbone, for comparable temperatures and solute concentrations, n-butanol produces a larger disordering than the other n-alkanols. This result probably reflects the greater fraction of time spent by the hydroxyl group of n-butanol in the vicinity of the lipid polar head group compared with the hydroxyl group in longer chain n-alkanols. It was found that n-octanol orders the acyl chains of DMPC, unlike n-butanol which disorders them, and the longer chain n-alkanols which have little effect. Within experimental error, the effect of n-dodecanol on order at all sites in DMPC is the same as n-tetradecanol. The influence of n-alkanols on DMPC ordering at twelve sites has been compared with that of cholesterol which is shown to interact with DMPC bilayers in a distinctly different manner from the n-alkanols.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0005-2736(88)90048-x" target="_blank" rel="noreferrer noopener">10.1016/0005-2736(88)90048-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alcohols
*Lipid Bilayers
*Membrane Lipids
1988
Biochimica et biophysica acta
Dimyristoylphosphatidylcholine
Doane J W
Dubro D W
Magnetic Resonance Spectroscopy
Molecular Conformation
Phonphok N
Pope J M
Temperature
Westerman P W