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Text
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<a href="http://doi.org/10.1002/jez.b.22990" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jez.b.22990</a>
ISSN
1552-5015 1552-5007
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
NEOMED Postdoc Publications
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Title
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Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (balaena mysticetus).
Publisher
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Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
Date
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2020
2020-07-29
Subject
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aging; Cetacea; bone; whales; osteoblasts; hyperostosis
Creator
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Cooper LN; Ball HC; Vinyard CJ; Safadi FF; George JC; Thewissen JGM
Description
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Bowhead whales are among the longest-lived mammals with an extreme lifespan of about 211 years. During the first 25 years of their lives, rib bones increase in mineral density and the medulla transitions from compact to trabecular bone. Molecular drivers associated with these phenotypic changes in bone remain unknown. This study assessed expression levels of osteogenic genes from samples of rib bones of bowheads. Samples were harvested from prenatal to 86-year-old whales, representing the first third of the bowhead lifespan. Fetal to 2-year-old bowheads showed expression levels consistent with the rapid deposition of the bone extracellular matrix. Sexually mature animals showed expression levels associated with low rates of osteogenesis and increased osteoclastogenesis. After the first 25 years of life, declines in osteogenesis corresponded with increased expression of EZH2, an epigenetic regulator of osteogenesis. These findings suggest EZH2 may be at least one epigenetic modifier that contributes to the age-related changes in the rib bone phenotype along with the transition from compact to trabecular bone. Ancient cetaceans and their fossil relatives also display these phenotypes, suggesting EZH2 may have shaped the skeleton of whales in evolutionary history.
Identifier
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<a href="http://doi.org/10.1002/jez.b.22990" target="_blank" rel="noreferrer noopener">10.1002/jez.b.22990</a>
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journalArticle
2020
Aging
August 2020 List
Ball HC
Bone
Cetacea
Cooper LN
Department of Anatomy & Neurobiology
George JC
Hyperostosis
Journal of Experimental Zoology. Part B
Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
journalArticle
Molecular and Developmental Evolution
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED Postdoc Publications
Osteoblasts
Safadi FF
Thewissen JGM
Vinyard CJ
WHALES