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40
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Text
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URL Address
<a href="http://doi.org/10.1186/s13041-018-0376-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s13041-018-0376-5</a>
Pages
34–34
Issue
1
Volume
11
Dublin Core
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Title
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RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.
Publisher
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Molecular brain
Date
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2018
2018-06
Subject
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Animals; Gene Expression Profiling; Gene Ontology; Hippocampus/*pathology; Immunity; Interferon-beta/metabolism; Kainic Acid; Mice; Microglia/*metabolism/*pathology; RNA/*methods; Seizures/*chemically induced; Sequence Analysis; Signal Transduction/genetics; Up-Regulation/genetics
Creator
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Bosco Dale B; Zheng Jiaying; Xu Zhiyan; Peng Jiyun; Eyo Ukpong B; Tang Ke; Yan Cheng; Huang Jun; Feng Lijie; Wu Gongxiong; Richardson Jason R; Wang Hui; Wu Long-Jun
Description
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Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood. As such, we utilized RNAseq analysis upon microglia isolated from the hippocampus to determine expression pattern alterations following kainic acid induced seizure. We determined that microglia undergo dramatic changes to their expression patterns, particularly with regard to mitochondrial activity and metabolism. We also observed that microglia initiate immunological activity, specifically increasing interferon beta responsiveness. Our results provide novel insights into microglia transcriptional regulation following acute seizures and suggest potential therapeutic targets specifically in microglia for the treatment of seizures and epilepsy.
Identifier
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<a href="http://doi.org/10.1186/s13041-018-0376-5" target="_blank" rel="noreferrer noopener">10.1186/s13041-018-0376-5</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animals
Bosco Dale B
Department of Pharmaceutical Sciences
Eyo Ukpong B
Feng Lijie
Gene Expression Profiling
Gene Ontology
Hippocampus/*pathology
Huang Jun
Immunity
Interferon-beta/metabolism
Kainic Acid
Mice
Microglia/*metabolism/*pathology
Molecular brain
NEOMED College of Pharmacy
Peng Jiyun
Richardson Jason R
RNA/*methods
Seizures/*chemically induced
Sequence Analysis
Signal Transduction/genetics
Tang Ke
Up-Regulation/genetics
Wang Hui
Wu Gongxiong
Wu Long-Jun
Xu Zhiyan
Yan Cheng
Zheng Jiaying