Blue foot: a second case of "tattoo blow-out" pigment spread successfully treated with the QS-Nd:YAG laser.
Adult; Female; Humans; *Foot; *Laser Therapy; Tattooing/*adverse effects; Lasers; Solid-State/*therapeutic use
The "tattoo blow-out" phenomenon occurs when tattoo pigments spread outside the border of a tattoo. It is thought to occur when ink is injected too deeply. A healthy 36-year-old female presented to a dermatologist with diffuse spread of tattoo pigment outside the original tattoo that occurred within one day of the placement of a professional tattoo on the dorsum of her foot. The patient was seeking treatment six weeks after the tattoo was placed because she thought the discoloration would improve or resolve on its own, but it worsened. Two punch biopsies were obtained for histology. The biopsy results confirmed granular black pigment consistent with a tattoo in the dermis and subcutaneous fat. The location of pigment was deeper than expected. Due to the success of the QS-Nd:YAG laser in a prior patient, the same treatment was recommended for this patient. The patient received nine laser sessions using the Q-switched laser at 1064 nm, 4 mm, 10 Hz, with gradually increasing energy from 4.5 to 6.0 J/cm2. The pigment outside of the original tattoo borders faded and is barely perceptible. It is important that physicians be made aware of tattoo complications so they can advise patients in regards to the associated risks.
Khetarpal Shilpi; Molenda Matthew; Seiger Eric; Pui John; Obagi Suzan
Journal of drugs in dermatology : JDD
2010
2010-11
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes.
*Keratinocytes/metabolism/radiation effects; *Ultraviolet Rays; Cell Culture Techniques; Cells; Cultured; Epidermal Cells; Gene Expression Regulation/drug effects; Genetic/*radiation effects; Humans; Interleukin-12/*genetics/*metabolism/pharmacology; Transcription
Interleukin-12 (IL-12) is a proinflammatory and immunomodulatory cytokine that plays a critical role it in innate and adaptive immunity by inducing production of interferon-gamma and other cytokines. IL-12 was shown to block the ultraviolet light-induced immunosuppression, important in cancer immunosurveillance, cutaneous allergies and inflammation. To characterize the molecular effects of
Molenda Matthew; Mukkamala Lakshmi; Blumenberg Miroslav
Molecular immunology
2006
2006-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.molimm.2005.12.003" target="_blank" rel="noreferrer noopener">10.1016/j.molimm.2005.12.003</a>