1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.2001.86.3.1289</a>
Pages
1289–1296
Issue
3
Volume
86
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Electrical stimuli patterned after the theta-rhythm induce multiple forms of LTP.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-09
Subject
The topic of the resource
*Theta Rhythm; 2-Amino-5-phosphonovalerate/pharmacology; Animals; Calcium Channel Blockers/pharmacology; Calcium Channels/physiology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; Long-Evans; Long-Term Potentiation/drug effects/*physiology; Male; N-Methyl-D-Aspartate/physiology; N-Methylaspartate/pharmacology; Neuronal Plasticity/drug effects/*physiology; Nifedipine/pharmacology; Organ Culture Techniques; Rats; Receptors
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
The induction of long-term potentiation (LTP) by high-frequency stimulation is considered an acceptable model for the study of learning and memory. In area CA1 calcium influx through N-methyl-D-aspartate receptors (NMDARs; nmdaLTP) and/or
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">10.1152/jn.2001.86.3.1289</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Theta Rhythm
2-Amino-5-phosphonovalerate/pharmacology
2001
Animals
Calcium Channel Blockers/pharmacology
Calcium Channels/physiology
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
Journal of neurophysiology
Long-Evans
Long-Term Potentiation/drug effects/*physiology
Male
Morgan S L
N-Methyl-D-Aspartate/physiology
N-Methylaspartate/pharmacology
Neuronal Plasticity/drug effects/*physiology
Nifedipine/pharmacology
Organ Culture Techniques
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1999.82.2.736" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1999.82.2.736</a>
Pages
736–740
Issue
2
Volume
82
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
VDCCs and NMDARs underlie two forms of LTP in CA1 hippocampus in vivo.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-08
Subject
The topic of the resource
Animals; Calcium Channel Blockers/*pharmacology; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/*pharmacology; Excitatory Postsynaptic Potentials/drug effects; Hippocampus/*drug effects; Long-Evans; Long-Term Potentiation/*drug effects; Male; Membrane Potentials/physiology; N-Methyl-D-Aspartate/*antagonists & inhibitors; Rats; Receptors; Verapamil/pharmacology
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
N-methyl-D-aspartate receptor/channel (NMDAR) and voltage-dependent calcium channel (VDCC) antagonists applied independently reduce the magnitude of long-term potentiation (LTP) in area CA1 of the hippocampal slice preparation. When used in combination, the antagonists completely block the induction of LTP. In urethan-anesthetized rats we examined the effect of the NMDAR blocker MK-801 (0.1 mg/kg) and the VDCC blocker Verapamil (10 mg/kg) on LTP induction in area CA1. Extracellular recordings were obtained from stratum radiatum following stimulation of Schaffer collaterals. LTP was induced by a 200-Hz/100-ms tetanus repeated 10 times (2 s isi). Tetanus was given in the presence of intraperitoneal saline, MK-801, Verapamil, or both Verapamil and MK-801. When given separately, Verapamil and MK-801 both significantly reduced the magnitude of LTP as compared with control animals. When given together, the drugs blocked the induction of LTP completely. We conclude that like LTP in vitro, VDCCs and NMDAR underlie two forms of LTP in vivo.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1999.82.2.736" target="_blank" rel="noreferrer noopener">10.1152/jn.1999.82.2.736</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animals
Calcium Channel Blockers/*pharmacology
Dizocilpine Maleate/pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Excitatory Postsynaptic Potentials/drug effects
Hippocampus/*drug effects
Journal of neurophysiology
Long-Evans
Long-Term Potentiation/*drug effects
Male
Membrane Potentials/physiology
Morgan S L
N-Methyl-D-Aspartate/*antagonists & inhibitors
Rats
Receptors
Teyler T J
Verapamil/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0074-7742(01)45014-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0074-7742(01)45014-8</a>
Pages
253–267
Volume
45
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Synaptic plasticity and secondary epileptogenesis.
Publisher
An entity responsible for making the resource available
International review of neurobiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
1905-06
Subject
The topic of the resource
Animals; Epilepsy/etiology/*physiopathology; Humans; Long-Term Potentiation/physiology; Neuronal Plasticity/*physiology; Synapses/*physiology
Creator
An entity primarily responsible for making the resource
Teyler T J; Morgan S L; Russell R N; Woodside B L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0074-7742(01)45014-8" target="_blank" rel="noreferrer noopener">10.1016/s0074-7742(01)45014-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Animals
Epilepsy/etiology/*physiopathology
Humans
International review of neurobiology
Long-Term Potentiation/physiology
Morgan S L
Neuronal Plasticity/*physiology
Russell R N
Synapses/*physiology
Teyler T J
Woodside B L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(01)02913-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(01)02913-4</a>
Pages
90–96
Issue
1
Volume
917
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Epileptic-like activity induces multiple forms of plasticity in hippocampal area CA1.
Publisher
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Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-10
Subject
The topic of the resource
*Neuronal Plasticity; Animals; Calcium Channels; Electrophysiology; Epilepsy/chemically induced/*physiopathology; Hippocampus/*physiopathology; Ion Channels/physiology; L-Type/physiology; Long-Evans; Long-Term Potentiation/physiology; N-Methyl-D-Aspartate/metabolism; Potassium Chloride; Rats; Receptors; Synapses/physiology
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
Mesial temporal lobe epilepsy is a relatively common form of epilepsy that afflicts many thousands of people. It has been suggested that the development of primary and secondary foci may involve mechanisms similar to long-term potentiation (LTP). In vitro seizure models typically involve an increase in spontaneous asynchronous bursting activity (epileptiform activity) induced either by increasing excitation or decreasing inhibition. Previous experiments have indicated that these models often generate bursting activity that closely resembles epileptic activity. LTP is often observed following epileptiform activity. In area CA1 of the hippocampus two forms of LTP that are dependent on the activation of either the L-type voltage dependent calcium channel (vdccLTP) or the N-methyl-D-aspartate receptor/channel (nmdaLTP) have been described. It is unclear from previous experiments which type of LTP results from epileptiform activity. Recent evidence indicates that nmdaLTP is most likely a short-term type of plasticity while vdccLTP may be a long-lasting form of synaptic plasticity. Given the characteristics of vdccLTP it is a likely candidate mechanism to underlie the development and formation of secondary seizure foci. We have therefore tested the ability of epileptiform activity induced by elevated potassium chloride to induce multiple forms of LTP in area CA1 of the rat hippocampus. Elevation of extracellular potassium chloride resulted in spontaneous asynchronous bursting. The net result of the spontaneous asynchronous bursting was to induce a compoundLTP consisting of nmdaLTP and vdccLTP components.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(01)02913-4" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(01)02913-4</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Neuronal Plasticity
2001
Animals
Brain research
Calcium Channels
Electrophysiology
Epilepsy/chemically induced/*physiopathology
Hippocampus/*physiopathology
Ion Channels/physiology
L-Type/physiology
Long-Evans
Long-Term Potentiation/physiology
Morgan S L
N-Methyl-D-Aspartate/metabolism
Potassium Chloride
Rats
Receptors
Synapses/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/nlme.2001.4016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/nlme.2001.4016</a>
Pages
229–238
Issue
3
Volume
76
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Depotentiation of vdccLTP requires NMDAR activation.
Publisher
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Neurobiology of learning and memory
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-11
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Animals; Calcium Channel Blockers/*pharmacology; Calcium Channels/drug effects/*physiology; Electric Stimulation; Electrophysiology; Hippocampus/*physiology; Long-Evans; Long-Term Potentiation/*physiology; Male; N-Methyl-D-Aspartate/drug effects/*physiology; Nifedipine/*pharmacology; Organ Culture Techniques; Rats; Receptors; Synaptic Transmission/*physiology
Creator
An entity primarily responsible for making the resource
Morgan S L; Coussens C M; Teyler T J
Description
An account of the resource
Long-term potentiation is an enduring increase in synaptic efficacy following repeated stimulation of afferent fibers that is thought to underlie memory. In area CA1 of the hippocampus at least two forms of synaptic potentiation coexist at the same synapses; nmdaLTP and vdccLTP. NmdaLTP is induced by Ca2+ entry through NMDARs and is dependent on serine/threonine kinase activation, while vdccLTP is induced through Ca2+ entry through VDCCs and is dependent on tyrosine kinase activation. Depotentiation is a mechanism known to reverse nmdaLTP through phosphatase activation. The depotentiation of vdccLTP has not been previously investigated. We used hippocampal slices (area CA1) from male Long-Evans rats to induce vdccLTP with a 200-Hz tetanus in the presence of 50 microM APV. The 200-Hz tetanus resulted in a slowly developing vdccLTP that remained stable for at least 30 min. Thirty minutes after vdccLTP was induced, a low-frequency tetanus (3, 10, 20, 30, or 40 Hz) was applied in the presence of APV in an attempt to depotentiate vdccLTP. The 3- and 10-Hz low-frequency tetani resulted in no depotentiation. The 20- and 30-Hz tetani partially depotentiated vdccLTP (by approximately 13%), whereas the 40-Hz tetanus resulted in further potentiation. When APV was washed out prior to the 3-Hz low-frequency tetanus, the vdccLTP was completely depotentiated–presumably by NMDAR mechanisms. Our results indicate that vdccLTP is resistant to depotentiation under low-frequency stimulation conditions that readily depotentiate nmdaLTP. As tetanus frequencies are increased a small depotentiation is observed, suggesting that vdccLTP can be depotentiated to a small extent. When NMDARs are unblocked, vdccLTP can be completely depotentiated by a 3-Hz low-frequency tetanus, suggesting that vdccLTP can be depotentiated via activation of NMDAR mechanisms.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/nlme.2001.4016" target="_blank" rel="noreferrer noopener">10.1006/nlme.2001.4016</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2-Amino-5-phosphonovalerate/pharmacology
2001
Animals
Calcium Channel Blockers/*pharmacology
Calcium Channels/drug effects/*physiology
Coussens C M
Electric Stimulation
Electrophysiology
Hippocampus/*physiology
Long-Evans
Long-Term Potentiation/*physiology
Male
Morgan S L
N-Methyl-D-Aspartate/drug effects/*physiology
Neurobiology of learning and memory
Nifedipine/*pharmacology
Organ Culture Techniques
Rats
Receptors
Synaptic Transmission/*physiology
Teyler T J