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Text
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URL Address
<a href="http://doi.org/10.1097/00006534-200003000-00019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00006534-200003000-00019</a>
Pages
953–963
Issue
3
Volume
105
Dublin Core
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Title
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Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells.
Publisher
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Plastic and reconstructive surgery
Date
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2000
2000-03
Subject
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*Fibrin Tissue Adhesive; *Osteogenesis; Animals; Bone and Bones/chemistry/cytology/diagnostic imaging; Cattle; Cells; Cultured; Experimental; Implants; Injections; Mice; Non-programmatic; Nude; Osteopontin; Periosteum/*cytology; Radiography; Sialoglycoproteins/analysis
Creator
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Isogai N; Landis W J; Mori R; Gotoh Y; Gerstenfeld L C; Upton J; Vacanti J P
Description
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The purpose of this study was to determine whether a combination of fibrin glue and cultured periosteal cells will result in new bone formation at heterotopic sites in nude mice. Growing cells and developing matrices surrounding periosteal explants from the diaphyses of radii of newborn calves were minced and mixed with fibrin glue in a syringe. The cell/matrix-fibrin glue admixture was then injected into the subcutaneous space on the dorsum of athymic nude mice. After 12 weeks of implantation, gross morphology and histologic investigations showed newly formed bone structures in all cell/matrix-fibrin glue admixtures, but none in fibrin glue injected alone and used as control samples. Osteopontin, a protein important in bone development, was identified by a Western blot assay of the cell/matrix-fibrin glue composite. This study supports the feasibility of initiating site-directed formation of bone structures at heterotopic tissue sites by means of injection of cultured periosteal cells and matrix in a fibrin glue carrier.
Identifier
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<a href="http://doi.org/10.1097/00006534-200003000-00019" target="_blank" rel="noreferrer noopener">10.1097/00006534-200003000-00019</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fibrin Tissue Adhesive
*Osteogenesis
2000
Animals
Bone and Bones/chemistry/cytology/diagnostic imaging
Cattle
Cells
Cultured
Experimental
Gerstenfeld L C
Gotoh Y
Implants
Injections
Isogai N
Landis W J
Mice
Mori R
Non-programmatic
Nude
Osteopontin
Periosteum/*cytology
Plastic and reconstructive surgery
Radiography
Sialoglycoproteins/analysis
Upton J
Vacanti J P