Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice.
Animals; Body Weight/genetics; Brain-Derived Neurotrophic Factor/*deficiency/genetics/*metabolism; Corpus Striatum/*metabolism; Dopamine/*metabolism; Heterozygote; Homozygote; Hypothalamus/metabolism; Methamphetamine/pharmacology; Mice; Motor Activity/drug effects/physiology; Mutant Strains; Norepinephrine/metabolism; Olfactory Bulb/metabolism; Organ Specificity; Substantia Nigra/*metabolism; Walking/physiology
Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice. In the present report we evaluated various indices of nigrostriatal dopaminergic function between
Dluzen D E; Gao X; Story G M; Anderson L I; Kucera J; Walro J M
Experimental neurology
2001
2001-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1006/exnr.2001.7698" target="_blank" rel="noreferrer noopener">10.1006/exnr.2001.7698</a>
Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.
*Sex Characteristics; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; Male; Mice; Motor Activity/drug effects/physiology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/*pharmacology
It has been demonstrated that the gonadal steroid hormone estrogen can exert neuroprotective effects upon the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA)-induced neurotoxicity in female, but not male, mice. In contrast, the anti-estrogen, tamoxifen (TMX) can function as a NSDA neuroprotectant within both female and male mice. In an attempt to understand these effects of TMX, the effects of this anti-estrogen upon both behavioral and neurochemical indices of NSDA function were examined within female and male mice following treatment with MA. In general, TMX exerted markedly different (bi-directional) effects upon NSDA function between female and male mice. Notably, treatment with TMX resulted in a relative decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations within male mice and a relative increase in female mice when treated with MA to produce a significant gender difference. Similar effects were obtained for locomotor behaviors related with NSDA function. That is, TMX produced increases in horizontal activity, number of movements and total distance traveled within
Dluzen Dean E; Mickley Katherine R
Pharmacology, biochemistry, and behavior
2005
2005-01
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.pbb.2004.10.007" target="_blank" rel="noreferrer noopener">10.1016/j.pbb.2004.10.007</a>