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Text
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URL Address
<a href="http://doi.org/10.1002/mds.22517" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/mds.22517</a>
Pages
1054–1059
Issue
7
Volume
24
Dublin Core
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Title
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Gender differences in the association between antidepressant use and restless legs syndrome.
Publisher
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Movement disorders : official journal of the Movement Disorder Society
Date
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2009
2009-05
Subject
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*Sex Characteristics; 80 and over; 80 and Over; Adult; Aged; Antidepressive Agents – Adverse Effects; Antidepressive Agents – Classification; Antidepressive Agents/*adverse effects/classification; Female; Human; Humans; Male; Middle Age; Middle Aged; Observation; Observational Methods; Primary Health Care – Statistics and Numerical Data; Primary Health Care/statistics & numerical data; Regression; Regression Analysis; Reproduction; Restless Legs – Chemically Induced; Restless Legs Syndrome/*chemically induced; Risk Factors; Veterans; Young Adult
Creator
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Baughman Kristin R; Bourguet Claire C; Ober Scott K
Description
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Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women.
Identifier
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<a href="http://doi.org/10.1002/mds.22517" target="_blank" rel="noreferrer noopener">10.1002/mds.22517</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2009
80 and over
Adult
Aged
Antidepressive Agents – Adverse Effects
Antidepressive Agents – Classification
Antidepressive Agents/*adverse effects/classification
Baughman Kristin R
Bourguet Claire C
Department of Family & Community Medicine
Female
Human
Humans
Male
Middle Age
Middle Aged
Movement disorders : official journal of the Movement Disorder Society
NEOMED College of Medicine
Ober Scott K
Observation
Observational Methods
Primary Health Care – Statistics and Numerical Data
Primary Health Care/statistics & numerical data
Regression
Regression Analysis
Reproduction
Restless Legs – Chemically Induced
Restless Legs Syndrome/*chemically induced
Risk Factors
Veterans
Young Adult