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Text
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URL Address
<a href="http://doi.org/10.1002/ccd.27840" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ccd.27840</a>
Pages
345-353
Issue
2
Volume
93
ISSN
1522-726X
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Update Year & Number
June2020SubmittedList
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
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Title
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Safety and efficacy of transcatheter aortic valve replacement for native aortic valve regurgitation: A systematic review and meta-analysis.
Publisher
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Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Date
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2019
2019-02-01
Subject
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Female; Humans; Male; Aged; Middle Aged; Treatment Outcome; Risk Factors; Aged 80 and over; Risk Assessment; Prosthesis Design; Recovery of Function; Heart Valve Prosthesis; Aortic Valve/diagnostic imaging/physiopathology/surgery; aortic valve insufficiency; heart diseases; heart valve prosthesis; Transcatheter Aortic Valve Replacement/adverse effects/instrumentation/mortality; Aortic Valve Insufficiency/diagnostic imaging/mortality/physiopathology/surgery
Creator
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Rawasia WF; Khan MS; Usman MS; Siddiqi TJ; Mujeeb FA; Chundrigar M; Kalra A; Alkhouli M; Kavinsky CJ; Bhatt DL
Description
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OBJECTIVE: The objective of this study was to analyze the available literature on using transcatheter aortic valve replacement (TAVR) for native aortic regurgitation (AR). BACKGROUND: Surgical aortic valve replacement is the gold standard therapy for native AR. TAVR has emerged as an alternative approach in high-risk patients. METHODS: MEDLINE, Scopus, and Cochrane CENTRAL were searched for reports of at least 5 patients undergoing TAVR for native AR. Outcomes included 30-day mortality, myocardial infarction, stroke, major bleeding, postprocedural moderate to severe AR, and device success. Pooled estimates were calculated using a random-effects model. Subgroup analysis and a meta-regression were performed to study the effects of study level covariates on outcomes. RESULTS: Nineteen studies (n =998 patients) were included. The rate of procedural success per Valve Academic Research Consortium - 2 (VARC-2) criteria was 86.2% (78.8%-92.2%]. Thirty-day mortality was 11.9% (9.4%-14.7%). Subgroup analysis showed the use of new generation valves was associated with lower 30-day mortality (P = 0.02) and higher device success (P = 0.009) compared with early generation valves. There was no significant difference (P = 0.13) in the rate of 30-day mortality between patients receiving purpose-specific [8.2% (4.3%-13.1%); I2 = 0%] and nonpurpose specific valves [13.0% (8.2%-18.6%); I2 = 25%]. However, device success was higher (P = 0.02) in patients who received purpose-specific valves [96.3% (92.2%-98.9%); I2 = 0%] compared with nonpurpose specific valves [84.4% (75%-91.9%); I2 =46%]. CONCLUSION: TAVR for native AR is associated with acceptable procedural success but increased early mortality. However, the safety and the efficacy of the procedure increased with newer valves.
Identifier
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<a href="http://doi.org/10.1002/ccd.27840" target="_blank" rel="noreferrer noopener">10.1002/ccd.27840</a>
PMID: 30269437
Rights
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© 2018 Wiley Periodicals, Inc.
Format
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journalArticle
2019
Aged
Aged 80 and over
Alkhouli M
aortic valve insufficiency
Aortic Valve Insufficiency/diagnostic imaging/mortality/physiopathology/surgery
Aortic Valve/diagnostic imaging/physiopathology/surgery
Bhatt DL
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Chundrigar M
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Female
heart diseases
Heart Valve Prosthesis
Humans
journalArticle
June2020SubmittedList
Kalra A
Kavinsky CJ
Khan MS
Male
Middle Aged
Mujeeb FA
NEOMED College of Medicine
Prosthesis Design
Rawasia WF
Recovery of Function
Risk Assessment
Risk Factors
Siddiqi TJ
Transcatheter Aortic Valve Replacement/adverse effects/instrumentation/mortality
Treatment Outcome
Usman MS