1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/physiolgenomics.2000.2.3.129" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/physiolgenomics.2000.2.3.129</a>
Pages
129–136
Issue
3
Volume
2
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits.
Publisher
An entity responsible for making the resource available
Physiological genomics
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-04
Subject
The topic of the resource
*Gene Dosage; Aging/metabolism; Animals; Axons/metabolism; Body Weight/genetics; Cell Count; Coronary Vessels/innervation; Heart Rate/genetics; Heart/*innervation; Heterozygote; Homozygote; In Situ Nick-End Labeling; Knockout; Mice; Muscle Tonus/genetics; Mutant Strains; Myocardium/cytology/*metabolism; Neurotrophin 3/deficiency/*genetics; Norepinephrine/metabolism; Organ Size/genetics; Stellate Ganglion/cytology; Sympathetic Nervous System/cytology/*growth & development/metabolism; Tyrosine 3-Monooxygenase/metabolism
Creator
An entity primarily responsible for making the resource
Story G M; DiCarlo S E; Rodenbaugh D W; Dluzen D E; Kucera J; Maron M B; Walro J M
Description
An account of the resource
Whether two copies of the neurotrophin-3 (NT3) gene are necessary for proper development of cardiac sympathetic innervation was investigated in mice carrying a targeted inactivation of the NT3 gene. Heterozygous (+/-) and null (-/-) mutant mice had fewer stellate ganglion neurons than did wild-type (+/+) mice at postnatal day 0 (P0 or birth), and this deficit was maintained between adult (P60) +/- and +/+ mice. The sympathetic innervation of the heart matured postnatally in +/+ and +/- mice. Tyrosine hydroxylase (TH)-positive axons were restricted largely to the epicardium at P0, were concentrated around large blood vessels in the myocardium at P21, and were present among cardiac myocytes at P60. Cardiac norepinephrine (NE) concentrations paralleled the growth of the sympathetic axons into the heart. NE concentrations were equivalent among +/+, +/-, and -/- mice at birth, but differences between +/- and +/+ mice increased with age. Adult +/- mice also exhibited lower resting heart rates and sympathetic tonus than +/+ mice. Thus deletion of one copy of the NT3 gene translates into anatomical, biochemical, and functional deficits in cardiac sympathetic innervation of postnatal mice, thereby indicating a gene-dosage effect for the NT3 gene.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/physiolgenomics.2000.2.3.129" target="_blank" rel="noreferrer noopener">10.1152/physiolgenomics.2000.2.3.129</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Dosage
2000
Aging/metabolism
Animals
Axons/metabolism
Body Weight/genetics
Cell Count
Coronary Vessels/innervation
DiCarlo S E
Dluzen D E
Heart Rate/genetics
Heart/*innervation
Heterozygote
Homozygote
In Situ Nick-End Labeling
Knockout
Kucera J
Maron M B
Mice
Muscle Tonus/genetics
Mutant Strains
Myocardium/cytology/*metabolism
Neurotrophin 3/deficiency/*genetics
Norepinephrine/metabolism
Organ Size/genetics
Physiological genomics
Rodenbaugh D W
Stellate Ganglion/cytology
Story G M
Sympathetic Nervous System/cytology/*growth & development/metabolism
Tyrosine 3-Monooxygenase/metabolism
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2004.06.032" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2004.06.032</a>
Pages
201–208
Issue
1
Volume
128
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-related changes in nigrostriatal dopaminergic function are accentuated in +/- brain-derived neurotrophic factor mice.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
1905-06
Subject
The topic of the resource
*Aging; Animals; Brain-Derived Neurotrophic Factor/*genetics/*metabolism; Corpus Striatum/*metabolism; Dopamine/*biosynthesis; Mice; Motor Activity/physiology; Mutant Strains; Mutation; Substantia Nigra/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Anderson L I; Kucera J; Joyce J N; Osredkar T; Walro J M
Description
An account of the resource
The effects of a deletion for the brain derived neurotrophic factor (BDNF) allele (+/- BDNF) upon age-related changes in nigrostriatal dopaminergic (NSDA) function were assessed. Behavioral (beam crossing and spontaneous activity) and neurochemical (potassium-stimulated dopamine release from superfused striatum) measures were compared among Young (4-5 month), Middle (11-13 month) and Aged (19-21 month) +/- BDNF and their wild type littermate control (+/+ BDNF) mice. No statistically significant differences were obtained between +/+ and +/- BDNF mice at the Young age sampling period for any of the behavioral or neurochemical measures. Behavioral and neurochemical responses indices of NSDA function begin to diverge between +/+ and +/- Middle age BDNF mice and maximal differences were observed at the Aged period. For both movement and stereotypy times, scores obtained from +/+ mice were significantly decreased compared with +/- BDNF mice at the Aged period and center time scores of +/+ mice were decreased at both the Middle and Aged periods compared with +/- BDNF mice. Neurochemically, potassium-stimulated DA release of +/+ mice was significantly greater than +/- BDNF mice with maximal differences obtained at the Aged period. These results demonstrate marked differences in age-related changes of NSDA function between +/+ and +/- BDNF mice and suggest that the deletion of one allele for BDNF may make these mice more susceptible to age-related declines in NSDA function.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2004.06.032" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2004.06.032</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aging
2004
Anderson L I
Animals
Brain-Derived Neurotrophic Factor/*genetics/*metabolism
Corpus Striatum/*metabolism
Dluzen D E
Dopamine/*biosynthesis
Joyce J N
Kucera J
McDermott J L
Mice
Motor Activity/physiology
Mutant Strains
Mutation
Neuroscience
Osredkar T
Substantia Nigra/*metabolism
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2009.07.004</a>
Pages
1401–1411
Issue
11
Volume
78
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.
Publisher
An entity responsible for making the resource available
Biochemical pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-12
Subject
The topic of the resource
Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Female; Male; Messenger/biosynthesis; Mice; Mutant Strains; Protein Binding; Reserpine/pharmacology; RNA; Sex Characteristics; Substantia Nigra/*metabolism; Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
Creator
An entity primarily responsible for making the resource
Ji Jing; Bourque Melanie; Di Paolo Therese; Dluzen Dean E
Description
An account of the resource
Female mice with a heterozygous mutation of their dopamine transporter (+/- DAT) showed relatively robust reductions in striatal DAT specific binding (38-50%), while +/- DAT males showed modest reductions (24-32%). Significant decreases in substantia nigra DAT specific binding (42%) and mRNA (24%) were obtained in +/- DAT females, but not +/- DAT males (19% and 5%, respectively). The effects of this DAT perturbation upon vesicular monoamine transporter-2 (VMAT-2) function revealed significantly greater reserpine-evoked DA output from +/+ and +/- DAT female as compared to male mice and the DA output profile differed markedly between +/+ and +/- DAT females, but not males. No changes in VMAT-2 protein or mRNA levels were present among these conditions. On the basis of these data, we propose: (1) a genetic mutation of the DAT does not exert equivalent effects upon the DAT in female and male mice, with females being more affected; (2) an alteration in the DAT may also affect VMAT-2 function; (3) this interaction between DAT and VMAT-2 function is more prevalent in female mice; and (4) the +/- DAT mutation affects VMAT-2 function through an indirect mechanism, that does not involve an alteration in VMAT-2 protein or mRNA. Such DAT/VMAT-2 interactions can be of significance to the gender differences observed in drug addiction and Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2009.07.004</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Biochemical pharmacology
Bourque Melanie
Corpus Striatum/*metabolism
Di Paolo Therese
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Female
Ji Jing
Male
Messenger/biosynthesis
Mice
Mutant Strains
Protein Binding
Reserpine/pharmacology
RNA
Sex Characteristics
Substantia Nigra/*metabolism
Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(92)90050-k" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(92)90050-k</a>
Pages
185–188
Issue
3
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Locomotor activity but not conditioned place preference is differentially affected by a moderate dose of ethanol administered to P and NP rats.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-06
Subject
The topic of the resource
*Alcohol Drinking; *Environment; Animals; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Male; Motor Activity/*drug effects; Mutant Strains; Rats; Reinforcement (Psychology)
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The conditioned place preference (CPP) test and spontaneous motor activity were used in order to determine if ethanol-preferring (P) rats differ from ethanol nonpreferring (NP) rats after the administration of a moderate (1.0 g/kg) dose of ethanol. Results indicate that both of the selectively bred lines of rats found ethanol aversive, with little difference between the P and the NP rats. In contrast, the NP rats were shown to be more sensitive to the motor-impairing effect of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(92)90050-k" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(92)90050-k</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alcohol Drinking
*Environment
1992
Alcohol (Fayetteville, N.Y.)
Animals
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Male
Motor Activity/*drug effects
Mutant Strains
Rats
Reinforcement (Psychology)
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/exnr.2001.7698" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/exnr.2001.7698</a>
Pages
121–128
Issue
1
Volume
170
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice.
Publisher
An entity responsible for making the resource available
Experimental neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-07
Subject
The topic of the resource
Animals; Body Weight/genetics; Brain-Derived Neurotrophic Factor/*deficiency/genetics/*metabolism; Corpus Striatum/*metabolism; Dopamine/*metabolism; Heterozygote; Homozygote; Hypothalamus/metabolism; Methamphetamine/pharmacology; Mice; Motor Activity/drug effects/physiology; Mutant Strains; Norepinephrine/metabolism; Olfactory Bulb/metabolism; Organ Specificity; Substantia Nigra/*metabolism; Walking/physiology
Creator
An entity primarily responsible for making the resource
Dluzen D E; Gao X; Story G M; Anderson L I; Kucera J; Walro J M
Description
An account of the resource
Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice. In the present report we evaluated various indices of nigrostriatal dopaminergic function between
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/exnr.2001.7698" target="_blank" rel="noreferrer noopener">10.1006/exnr.2001.7698</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Anderson L I
Animals
Body Weight/genetics
Brain-Derived Neurotrophic Factor/*deficiency/genetics/*metabolism
Corpus Striatum/*metabolism
Dluzen D E
Dopamine/*metabolism
Experimental neurology
Gao X
Heterozygote
Homozygote
Hypothalamus/metabolism
Kucera J
Methamphetamine/pharmacology
Mice
Motor Activity/drug effects/physiology
Mutant Strains
Norepinephrine/metabolism
Olfactory Bulb/metabolism
Organ Specificity
Story G M
Substantia Nigra/*metabolism
Walking/physiology
Walro J M