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40
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Text
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URL Address
<a href="http://doi.org/10.1038/s41390-019-0624-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41390-019-0624-0</a>
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ISSN
1530-0447
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1038/s41390-019-0624-0" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1038/s41390-019-0624-0</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Premature birth impacts bolus size and shape through nursing in infant pigs
Publisher
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Pediatric Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-10-23
Creator
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Mayerl Christopher J; Myrla Alexis M; Bond Laura E; Stricklen Bethany M; German Rebecca Z; Gould Francois D H
Description
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BACKGROUND: The formation of a bolus of food is critical for proper feeding function, and there is substantial variation in the size and shape of a bolus prior to a swallow. Preterm infants exhibit decreased abilities to acquire and process food, but how that relates to their bolus size and shape is unknown. Here, we test two hypotheses: (1) that bolus size and shape will differ between term and preterm infants, and (2) bolus size and shape will change longitudinally through development in both term and preterm infants. METHODS: To test these hypotheses, we measured bolus size and shape in preterm and term infant pigs longitudinally through nursing using high-speed videofluoroscopy. RESULTS: Preterm infant pigs swallowed smaller volumes of milk. Although term infants increased the amount of milk per swallow as they aged, preterm infants did not. These changes in bolus volume were also correlated with changes in bolus shape; larger boluses became more elongate as they better filled the available anatomical space of the valleculae. CONCLUSIONS: These results suggest that preterm birth reduces the ability of preterm pigs to increase bolus size as they grow, affecting development in this fragile population. These results highlight that studies on term infant feeding may not translate to preterm infants.
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<a href="http://doi.org/10.1038/s41390-019-0624-0" target="_blank" rel="noreferrer noopener">10.1038/s41390-019-0624-0</a>
PMID: 31645052
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Bond Laura E
Department of Anatomy & Neurobiology
German Rebecca Z
Gould Francois D H
Journal Article
Mayerl Christopher J
Myrla Alexis M
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED Postdoc Publications
November 2019 Update
Pediatric Research
Stricklen Bethany M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-020-10118-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-020-10118-x</a>
ISSN
1432-0460 0179-051X
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Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s00455-020-10118-x" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s00455-020-10118-x</a>
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Postdoc Publications
NEOMED Student Publications
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model.
Publisher
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Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04-24
Subject
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Animal model; aspiration; children born; coordination; dysphagia; dysphagia; Feeding; laryngeal nerve lesion; low-birth-weight; Neonate; patent ductus-arteriosus; Performance; pharyngeal swallow; preterm; respiration
Creator
An entity primarily responsible for making the resource
Mayerl Christopher J; Myrla Alexis M; Gould Francois D H; Bond Laura E; Stricklen Bethany M; German Rebecca Z
Description
An account of the resource
Feeding difficulties are especially prevalent in preterm infants, although the mechanisms driving these difficulties are poorly understood due to a lack of data on healthy infants. One potential mechanism of dysphagia in adults is correlated with bolus volume. Yet, whether and how bolus volume impacts swallow safety in infant feeding is unknown. A further complication for safe infant swallowing is recurrent laryngeal nerve (RLN) injury due to patent ductus arteriosus surgery, which exacerbates the issues that preterm infants face and can increase the risk of dysphagia. Here, we used a validated animal model feeding freely to test the effect of preterm birth, postnatal maturation and RLN lesion and their interactions on swallow safety. We also tested whether bolus size differed with lesion or birth status, and the relationship between bolus size and swallow safety. We found very little effect of lesion on swallow safety, and preterm infants did not experience more penetration or aspiration than term infants. However, term infants swallowed larger boluses than preterm infants, even after correcting for body size. Bolus size was the primary predictor of penetration or aspiration, with larger boluses being more likely to result in greater degrees of dysphagia irrespective of age or lesion status. These results highlight that penetration and aspiration are likely normal occurrences in infant feeding. Further, when comorbidities, such as RLN lesion or preterm birth are present, limiting bolus size may be an effective means to reduce incidences of penetration and aspiration.
Identifier
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<a href="http://doi.org/10.1007/s00455-020-10118-x" target="_blank" rel="noreferrer noopener">10.1007/s00455-020-10118-x</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Animal model
Aspiration
Bond Laura E
children born
coordination
Department of Anatomy & Neurobiology
Dysphagia
Feeding
German Rebecca Z
Gould François D H
journalArticle
June 2020 Update II
laryngeal nerve lesion
low-birth-weight
Mayerl Christopher J
Myrla Alexis M
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED College of Medicine Student
NEOMED Postdoc Publications
NEOMED Student Publications
neonate
patent ductus-arteriosus
Performance
pharyngeal swallow
preterm
Respiration
Stricklen Bethany M