Neurodegenerative diseases are complex disorders with several pathoetiological pathways leading to cell death. Rationally designed multi-targeted agents, or "multi-targeted designed drugs" (MTDD) show significant promise in preclinical studies as…
The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and…
Conditioning stimulation applied to afferent fibers in stratum radiatum or stratum oriens of hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of excitatory postsynaptic potentials (EPSPs). PTD amounted to a
