1
40
3
-
Text
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URL Address
<a href="http://doi.org/10.1016/0304-3940(90)90603-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(90)90603-7</a>
Pages
309–314
Issue
3
Volume
113
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.
Publisher
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Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-06
Subject
The topic of the resource
Animals; Action Potentials/drug effects; Electric Stimulation; In Vitro Techniques; Hippocampus/drug effects/*physiology; 2-Amino-5-phosphonovalerate/*pharmacology; Neuronal Plasticity/*drug effects; Calcium/*pharmacology; Receptors; N-Methyl-D-Aspartate; Neurotransmitter/antagonists & inhibitors/*physiology
Creator
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Grover L M; Teyler T J
Description
An account of the resource
Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent, post-synaptic mechanisms. Tetanus-induced long-term potentiation (LTP) was blocked by 50 microM D,L-2-amino-5-phosphonovalerate (APV) as previously reported by others. In contrast, Ca2(+)-induced long-lasting potentiation was not reduced by 50 microM APV. Thus the mechanisms by which tetanic stimulation and exposure to high Ca2+ induce synaptic potentiation may differ.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(90)90603-7" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(90)90603-7</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
2-Amino-5-phosphonovalerate/*pharmacology
Action Potentials/drug effects
Animals
Calcium/*pharmacology
Electric Stimulation
Grover L M
Hippocampus/drug effects/*physiology
In Vitro Techniques
N-Methyl-D-Aspartate
Neuronal Plasticity/*drug effects
Neuroscience letters
Neurotransmitter/antagonists & inhibitors/*physiology
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-0270(89)90015-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-0270(89)90015-0</a>
Pages
101–108
Issue
1
Volume
28
Dublin Core
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Title
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Comparative aspects of hippocampal and neocortical long-term potentiation.
Publisher
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Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-05
Subject
The topic of the resource
Animals; Electric Stimulation; Action Potentials; Hippocampus/*physiology; Visual Cortex/*physiology; Evoked Potentials; Memory/physiology; Receptors; N-Methyl-D-Aspartate; Neurotransmitter/*physiology
Creator
An entity primarily responsible for making the resource
Teyler T J
Description
An account of the resource
Long-term potentiation (LTP) is a candidate for the synaptic alternations underlying memory storage in the mammalian CNS. In this chapter LTP in hippocampus and in visual neocortex are compared. Comparisons of the optimal tetanus parameters revealed that 2-3 trains of high-frequency stimulation (100-400 Hz) delivered within a brief period of time (minutes) results in maximal potentiation in hippocampal synapses. In contrast, the parameters most effective in neocortex were either low-frequency (2 Hz for 60 min) or high-frequency bursts (100 Hz, 100 ms train at 1/5 s for 10 min), both of which deliver at least an order of magnitude more afferent activation than that required for hippocampus. Hippocampal population spike potentiation averages 250% and the population excitatory postsynaptic potential (EPSP) potentiation averages 50%. Neocortical LTP also averages about 50%. The expression of LTP requires about 5 min in CA1 hippocampus, whereas about 30 min are required for expression of neocortical potentiation. Both hippocampus and visual neocortex display an enhanced potentiation early in development, with a later stabilization at lower adult levels. Centering at postnatal day 15, hippocampal CA1 displays an LTP magnitude that is over twice that seen at day 60. Neocortical responses display a similar peak at postnatal day 15 and a subsequent adult stabilization at approximately half of the day 15 maximum. Both tissues first display LTP during the early stages of synapse formation between postnatal days 6-10. The role of the NMDA receptor is implicated in aspects of both hippocampal and neocortical LTP.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-0270(89)90015-0" target="_blank" rel="noreferrer noopener">10.1016/0165-0270(89)90015-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Action Potentials
Animals
Electric Stimulation
Evoked Potentials
Hippocampus/*physiology
Journal of neuroscience methods
Memory/physiology
N-Methyl-D-Aspartate
Neurotransmitter/*physiology
Receptors
Teyler T J
Visual Cortex/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(93)90167-j" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(93)90167-j</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
43-46
Issue
1
Volume
154
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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DEVELOPMENTAL ALTERATIONS IN N-METHYL-D-ASPARTATE STIMULATED H-3 NOREPINEPHRINE RELEASE IN RAT-BRAIN CORTEX AND HIPPOCAMPUS
Publisher
An entity responsible for making the resource available
Neuroscience Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
hippocampus; cortex; development; receptors; Neurosciences & Neurology; system; ethanol; postnatal-development; cerebral-cortex; visual cortex; excitatory amino-acids; [h-3]norepinephrine release; n-methyl-d-aspartate; nmda-binding-sites; norepinephrine release; slice
Creator
An entity primarily responsible for making the resource
Brown L M
Description
An account of the resource
Developmental alterations in N-methyl-D-aspartate (NMDA)-stimulated [H-3]norepinephrine release from rat brain cortical and hippocampal slices were studied. NMDA (10-1000 muM) resulted in a concentration-dependent increase in [H-3]norepinephrine efflux; maximal responses (% released) in the cortex were: (1.53 +/- 0. 12, 3.68 +/- 0.20, 2.94 +/- 0.20, 4.60 +/- 0.28 and 5.28 +/- 0.33) and the hippocampal responses were: (1.90 +/- 0.18, 3.84 +/- 0.23, 3.60 +/- 0.28, 5.16 +/- 0.38 and 5.81 +/- 0.45) at varying postnatal ages (1, 7, 14, 21 and 90 days) respectively. Cortical tissue from 7-day-old pups exhibited a transient increase in maximal efflux and a decrease in EC50. These results indicated that developmental alterations in the NMDA receptor appear to be translated into differences in NMDA stimulated [H-3]norepinephrine release.
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<a href="http://doi.org/10.1016/0304-3940(93)90167-j" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(93)90167-j</a>
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Journal Article or Conference Abstract Publication
[h-3]norepinephrine release
1993
Brown L M
cerebral-cortex
cortex
development
ETHANOL
excitatory amino-acids
Hippocampus
Journal Article or Conference Abstract Publication
N-Methyl-D-Aspartate
Neuroscience letters
Neurosciences & Neurology
nmda-binding-sites
norepinephrine release
postnatal-development
Receptors
slice
system
visual cortex