1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/B978-0-12-818969-6.00020-0</a> Pages 299-307 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/B978-0-12-818969-6.00020-0</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number January 2021 List NEOMED College NEOMED College of Medicine NEOMED Department Department of Anatomy & Neurobiology Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chapter 20 - Molecular insights into anatomy and physiology Publisher An entity responsible for making the resource available The Bowhead Whale Date A point or period of time associated with an event in the lifecycle of the resource 2021 2021-01-01 Subject The topic of the resource DNA; lipid; blubber; Bowhead whale; Balaena mysticetus; molecular evolution; longevity Creator An entity primarily responsible for making the resource Cooper LN; Gorbunova V Description An account of the resource Bowhead whales are some of the largest animals that occupy the Arctic Circle. Despite the challenges of living and giving birth in icy waters, having huge blubber stores, eating a fat-rich diet, and undergoing arduous migrations, bowheads achieved the longest known life span of mammals of 268 years. Their longevity is extended by fixed mutations that prevent DNA damage and cancer and through evolutionary modifications to their metabolism that compensate for an oxygen-poor environment. Recently, the bowhead genome and transcriptome libraries were made publicly available for study. Analyses suggest that their life span has been extended by evolutionary changes that result in the upregulation of DNA repair pathways. Molecular biologists are now undertaking laboratory experiments with whale samples that are informed by the bowhead genome and transcriptome to tackle questions that were inaccessible using classical model organisms such as rodents or fish. Biomedical researchers are also applying insights gained from research on bowheads into investigations of potential therapies for aging, senescence, and cancer. Moreover, researchers are using these results to inform our understanding of the evolutionary history of these traits. This chapter reviews the molecular basis for bowhead whale longevity and survival in their unique habitat and offers insights for further exploration into the molecular mechanisms that shape the extraordinary lives of these animals. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener"></a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2021 Balaena mysticetus Blubber bowhead whale Cooper LN Department of Anatomy & Neurobiology DNA Gorbunova V January 2021 List journalArticle lipid longevity molecular evolution NEOEMD College of Medicine The Bowhead Whale