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Text
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URL Address
<a href="http://doi.org/10.1016/j.ajpath.2018.05.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajpath.2018.05.004</a>
Pages
1807–1819
Issue
8
Volume
188
Dublin Core
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Title
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Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.
Publisher
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The American journal of pathology
Date
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2018
2018-08
Creator
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Wang Jiayou; Kainrad Noah; Shen Hong; Zhou Zhou; Rote Paula; Zhang Yanqiao; Nagy Laura E; Wu Jiashin; You Min
Description
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Aberrant precursor mRNA splicing plays a pivotal role in liver diseases. However, roles of splicing regulators in alcoholic liver disease are unknown. Herein, we investigated a splicing regulator, Slu7, in the development of alcoholic steatohepatitis. Adenovirus-mediated alteration of hepatic Slu7 expression in mice pair fed either with or without (as control) ethanol in their diet was used. Knockdown of hepatic Slu7 by adenovirus-Slu7shRNA treatment ameliorated inflammation and attenuated liver injury in mice after ethanol administration. Mechanistically, reducing liver Slu7 expression increased the expression of sirtuin 1 (SIRT1) full-length and repressed the splicing of SIRT1 into
Identifier
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<a href="http://doi.org/10.1016/j.ajpath.2018.05.004" target="_blank" rel="noreferrer noopener">10.1016/j.ajpath.2018.05.004</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Department of Pharmaceutical Sciences
Kainrad Noah
Nagy Laura E
NEOMED College of Pharmacy
Rote Paula
Shen Hong
The American journal of pathology
Wang Jiayou
Wu Jiashin
You Min
Zhang Yanqiao
Zhou Zhou