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<a href="http://doi.org/10.1016/j.colsurfb.2012.02.005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.colsurfb.2012.02.005</a>
Pages
259–265
Volume
94
Dublin Core
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Title
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Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.
Publisher
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Colloids and surfaces. B, Biointerfaces
Date
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2012
2012-06
Subject
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Animals; ATP Binding Cassette Transporter; Calorimetry; Differential Scanning; Drug Carriers/*chemical synthesis/pharmacokinetics; Drug Stability; Emulsions/chemistry; Fatty Alcohols/*chemistry; Fourier Transform Infrared; Humans; Inbred BALB C; Macrophages/*drug effects/metabolism; Member 1/metabolism; Mice; Nanoparticles/*chemistry/ultrastructure; Oils/chemistry; Paclitaxel/pharmacokinetics; Particle Size; Polyethylene Glycols/*chemistry; Reactive Oxygen Species/metabolism; Rhodamine 123/metabolism; Spectroscopy; Subfamily B; Water/chemistry
Creator
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Wehrung Daniel; Geldenhuys Werner J; Oyewumi Moses O
Description
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The main objective of the study is to investigate the efficacy of Gelucire 44/14 (gelucire) in facilitating formation of cetyl alcohol (CA)-based nanoparticle (NP) and to assess the effects on key NP properties and functions. NPs from oil-in-water nanoemulsion precursors were prepared using binary mixtures of CA and gelucire (CA/gelucire) containing gelucire at 0, 25, 50 and 75% (w/w). The sizes of gelucire-based NPs (128-183 nm) were five times lower than control NPs (made without gelucire). All the NPs (with or without gelucire component) did not activate macrophages as monitored by reactive oxygen species production. Results from differential scanning calorimetry, FT-IR and multimodal light scattering measurements demonstrated the involvement of gelucire component in achieving homogeneous CA/gelucire particle populations that were stable on storage. The
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<a href="http://doi.org/10.1016/j.colsurfb.2012.02.005" target="_blank" rel="noreferrer noopener">10.1016/j.colsurfb.2012.02.005</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
ATP Binding Cassette Transporter
Calorimetry
Colloids and surfaces. B, Biointerfaces
Department of Pharmaceutical Sciences
Differential Scanning
Drug Carriers/*chemical synthesis/pharmacokinetics
Drug Stability
Emulsions/chemistry
Fatty Alcohols/*chemistry
Fourier Transform Infrared
Geldenhuys Werner J
Humans
Inbred BALB C
Macrophages/*drug effects/metabolism
Member 1/metabolism
Mice
Nanoparticles/*chemistry/ultrastructure
NEOMED College of Pharmacy
Oils/chemistry
Oyewumi Moses O
Paclitaxel/pharmacokinetics
Particle Size
Polyethylene Glycols/*chemistry
Reactive Oxygen Species/metabolism
Rhodamine 123/metabolism
Spectroscopy
Subfamily B
Water/chemistry
Wehrung Daniel