1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jnn.2017.13449</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4867-4881
Issue
7
Volume
17
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Engineering Alkoxyphenacyl-Polycarbonate Nanoparticles for Potential Application in Near-Infrared Light-Modulated Drug Delivery via Photon Up-Conversion Process
Publisher
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Journal of Nanoscience and Nanotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-07
Subject
The topic of the resource
800 nm; alkoxylphenacyl-based polycarbonates; biocompatibility; Chemistry; Doxorubicin; Drug Release; luminescence; Materials Science; mesoporous-silica; nanocrystals; Nanotechnology; Near-Infrared Light; photodynamic therapy; Physics; release; Science & Technology - Other Topics; Stimuli-Responsive; upconverting nanoparticles; uv
Creator
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Wehrung D; Chamsaz E A; Andrews J H; Joy A; Oyewumi M O
Description
An account of the resource
Photoresponsive delivery systems that are activated by high energy photo-triggers have been accorded much attention because of the capability to achieve reliable photoreactions at short irradiation times. However, the application of a high energy photo-trigger (UV light) is not clinically viable. Meanwhile, the process of photon-upconversion is an effective strategy to generate a high energy photo-trigger (in-situ) through exposure to clinically relevant near-infrared (NIR) light. In this regard, we synthesized photon upconverting nanocrystals (UCNCs) that were subsequently loaded into photoresponsive nanoparticles (NPs) that were prepared using alkoxyphenacyl-based polycarbonate homopolymer (UCNC-APP-NPs). UCNC loading affected resultant NP size, size distribution, colloidal stability but not the zeta potential. The efficiency of NIR-modulated drug delivery was impacted by the heterogenetic nature of the resultant UCNC-APP-NPs which was plausibly formed through a combination of UCNC entrapment within the polymeric NP matrix and nucleation of polymer coating on the surface of the UCNCs. The biocompatibility of UCNC-APP-NPs was demonstrated through cytotoxicity, macrophage activation, and red blood cell lysis assays. Studies in tumor-bearing (nu/nu) athymic mice showed a negligible distribution of UCNC-APP-NPs to reticuloendothelial tissues. Further, distribution of UCNC-APP-NPs to various tissues was in the order (highest to lowest): Lungs> Tumor > Kidneys > Liver > Spleen> Brain > Blood > Heart. In all, the work highlighted some important factors that may influence the effectiveness, reproducibility and biocompatibility of drug delivery systems that operate on the process of photon-upconversion.
Identifier
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<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">10.1166/jnn.2017.13449</a>
Format
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Journal Article
2017
800 nm
alkoxylphenacyl-based polycarbonates
Andrews J H
Biocompatibility
Chamsaz E A
Chemistry
Department of Pharmaceutical Sciences
Doxorubicin
Drug Release
Journal Article
Journal of nanoscience and nanotechnology
Joy A
luminescence
Materials Science
mesoporous-silica
nanocrystals
Nanotechnology
Near-Infrared Light
NEOMED College of Pharmacy
Oyewumi M O
photodynamic therapy
Physics
release
Science & Technology - Other Topics
Stimuli-responsive
upconverting nanoparticles
uv
Wehrung D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ejpb.2014.07.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejpb.2014.07.011</a>
Pages
962–972
Issue
3
Volume
88
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates.
Publisher
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-11
Subject
The topic of the resource
Animals; Biocompatibility; Cardiotoxicity; Cell Line; Chemistry; Dose-Response Relationship; Doxorubicin; Drug; Drug Delivery Systems/*methods; Heart/drug effects; Humans; Inbred BALB C; Mice; Nanotechnology; Pharmaceutical; Photic Stimulation/*methods; Photoresponsive; Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity; Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity; Polymer chain scission; Stimuli-responsive; Tumor
Creator
An entity primarily responsible for making the resource
Wehrung Daniel; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O
Description
An account of the resource
Recently, we reported the synthesis and biocompatibility of alkoxylphenacyl-based polycarbonates (APP); a promising new class of polymers that undergo photo-induced chain scission. In the current study, nanoparticles (NPs) were prepared from the APP polymer (APP-NPs) and loaded with doxorubicin (DOX) (DOX-APP-NPs) in order to identify and evaluate formulation and photoirradiation parameters that influence photoresponsive efficacy. Stable and spherical APP-NPs were prepared with diameters between 70-80nm depending on APP concentration (10-40mg/mL). There was a direct relationship between APP concentration and resultant particle size. Drug release studies indicated that exposure to the photo-trigger was capable of altering the rate and extent of DOX released. Photoresponsive DOX release was markedly influenced by the frequency of photoirradiation while the effect of APP concentration was most likely propagated through NP size. DOX released by photoactivation retained its efficacy as assessed by cytotoxicity studies in human lung adenocarcinoma (A549) cells. Studies in BALB/c mice indicated that DOX-APP-NPs induce less cardiotoxicity than DOX alone and that DOX-APP-NPs are not susceptible to dose dumping after photoirradiation.
Identifier
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<a href="http://doi.org/10.1016/j.ejpb.2014.07.011" target="_blank" rel="noreferrer noopener">10.1016/j.ejpb.2014.07.011</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Biocompatibility
Cardiotoxicity
Cell Line
Chamsaz Elaheh A
Chemistry
Department of Pharmaceutical Sciences
Dose-Response Relationship
Doxorubicin
Drug
Drug Delivery Systems/*methods
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Heart/drug effects
Humans
Inbred BALB C
Joy Abraham
Mice
Nanotechnology
NEOMED College of Pharmacy
Oyewumi Moses O
Pharmaceutical
Photic Stimulation/*methods
Photoresponsive
Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity
Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity
Polymer chain scission
Stimuli-responsive
Tumor
Wehrung Daniel