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Text
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URL Address
<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/01635581.2016.1115094</a>
Pages
120–130
Issue
1
Volume
68
Dublin Core
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Title
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Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Publisher
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Nutrition and cancer
Date
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2016
1905-07
Subject
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*Punicaceae/chemistry; 10-Dimethyl-1; 2-benzanthracene; 9; Animal Studies; Animals; Anticarcinogenic Agents/*therapeutic use; Apoptosis; Apoptosis/*drug effects; Breast Neoplasms – Mortality; Breast Neoplasms – Prevention and Control; Breast Neoplasms – Risk Factors; Cell Physiology; Cell Proliferation/*drug effects; Diet – Evaluation; Experimental/pathology/*prevention & control; Female; Funding Source; Gene Expression Regulation; Genes; Human; Immunohistochemistry; Mammary Neoplasms; Mutation; National Institutes of Health (U.S.); Neoplasms – Prevention and Control; Phytotherapy; Pomegranate; Proto-Oncogene Proteins c-bcl-2/analysis; Rats; Sprague-Dawley; Tamoxifen; United States
Creator
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Bishayee Anupam; Mandal Animesh; Bhattacharyya Piyali; Bhatia Deepak
Description
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Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of its various health benefits. This study was initiated to investigate chemopreventive potential of a pomegranate emulsion (PE) against 7,12-dimethylbenz(a)anthracene (DMBA) rat mammary carcinogenesis. The animals were orally administered with PE (0.2-5.0 g/kg), starting 2 wk before and 16 wk following DMBA treatment. PE exhibited a striking reduction of DMBA-induced mammary tumor incidence, total tumor burden, and reversed histopathological changes. PE dose-dependently suppressed cell proliferation and induced apoptosis in mammary tumors. Immunohistochemical studies showed that PE increased intratumor Bax, decreased Bcl2 and manifested a proapoptotic shift in Bax/Bcl2 ratio. In addition, our gene expression study showed PE-mediated upregulation of Bad, caspase-3, caspase-7, caspase-9, poly (ADP ribose) polymerase and cytochrome c in mammary tumors. Thus, PE exerts chemoprevention of mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis mediated through upregulation of Bax and downregulation of Bcl2 in concert with caspase cascades. Pomegranate bioactive phytoconstituents could be developed as a chemopreventive drug to reduce the risk of breast cancer.
Identifier
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<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">10.1080/01635581.2016.1115094</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Punicaceae/chemistry
10-Dimethyl-1
2-benzanthracene
2016
9
Animal Studies
Animals
Anticarcinogenic Agents/*therapeutic use
Apoptosis
Apoptosis/*drug effects
Bhatia Deepak
Bhattacharyya Piyali
Bishayee Anupam
Breast Neoplasms – Mortality
Breast Neoplasms – Prevention and Control
Breast Neoplasms – Risk Factors
Cell Physiology
Cell Proliferation/*drug effects
Diet – Evaluation
Experimental/pathology/*prevention & control
Female
Funding Source
Gene Expression Regulation
Genes
Human
Immunohistochemistry
Mammary Neoplasms
Mandal Animesh
Mutation
National Institutes of Health (U.S.)
Neoplasms – Prevention and Control
Nutrition and cancer
Phytotherapy
Pomegranate
Proto-Oncogene Proteins c-bcl-2/analysis
Rats
Sprague-Dawley
Tamoxifen
United States