1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/nu9050436</a>
Issue
5
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.
Publisher
An entity responsible for making the resource available
Nutrients
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
Female; Animals; Anti-Inflammatory Agents/*pharmacology; Rats; Gene Expression Regulation; Signal Transduction; Apoptosis/drug effects; anti-inflammatory effects; Anticarcinogenic Agents/pharmacology; breast tumor; COX-2; Cyclooxygenase 2/genetics/metabolism; DMBA; HSP90; HSP90 Heat-Shock Proteins/genetics/metabolism; I-kappa B Kinase/genetics/metabolism; NF-E2-Related Factor 2/genetics/*metabolism; NF-kappa B/genetics/*metabolism; NF-kappaB; Nrf2; Plant Preparations/*pharmacology; Punica granatum; Punicaceae/*chemistry; Pomegranate; Chemoprevention; Dose-Response Relationship; Drug; Neoplastic; Mammary Neoplasms; 10-Dimethyl-1; 9; Neoplastic/drug effects; Cell Transformation; 2-benzanthracene/toxicity; Experimental/*prevention & control; Animal Studies; Breast Neoplasms; Inflammation Mediators; Physical Education and Training; Neoplasms – Prevention and Control
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bhatia Deepak; Bishayee Anupam
Description
An account of the resource
Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a striking inhibition of dimethylbenz(a)anthracene (DMBA)-initiated rat mammary tumorigenesis via antiproliferative and apoptosis-inducing mechanisms. The objective of the present work is to investigate the anti-inflammatory mechanism of action of PE during DMBA rat mammary carcinogenesis by evaluating the expression of cyclooxygenase-2 (COX-2), heat shock protein 90 (HSP90), nuclear factor-kappaB (NF-kappaB) and nuclear factor erythroid 2p45 (NF-E2)-related factor 2 (Nrf2). Mammary tumor samples were harvested from our previous chemopreventive study in which PE (0.2-5.0 g/kg) was found to reduce mammary tumorigenesis in a dose-dependent manner. The expressions of COX-2, HSP90, NF-kappaB, inhibitory kappaBalpha (IkappaBalpha) and Nrf2 were detected by immunohistochemical techniques. PE decreased the expression of COX-2 and HSP90, prevented the degradation of IkappaBalpha, hindered the translocation of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">10.3390/nu9050436</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/toxicity
2017
9
Animal Studies
Animals
Anti-Inflammatory Agents/*pharmacology
anti-inflammatory effects
Anticarcinogenic Agents/pharmacology
Apoptosis/drug effects
Bhatia Deepak
Bishayee Anupam
Breast Neoplasms
breast tumor
Cell Transformation
Chemoprevention
COX-2
Cyclooxygenase 2/genetics/metabolism
DMBA
Dose-Response Relationship
Drug
Experimental/*prevention & control
Female
Gene Expression Regulation
HSP90
HSP90 Heat-Shock Proteins/genetics/metabolism
I-kappa B Kinase/genetics/metabolism
Inflammation Mediators
Mammary Neoplasms
Mandal Animesh
Neoplasms – Prevention and Control
Neoplastic
Neoplastic/drug effects
NF-E2-Related Factor 2/genetics/*metabolism
NF-kappa B/genetics/*metabolism
NF-kappaB
Nrf2
Nutrients
Physical Education and Training
Plant Preparations/*pharmacology
Pomegranate
Punica granatum
Punicaceae/*chemistry
Rats
Signal Transduction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/01635581.2016.1115094</a>
Pages
120–130
Issue
1
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Publisher
An entity responsible for making the resource available
Nutrition and cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
1905-07
Subject
The topic of the resource
*Punicaceae/chemistry; 10-Dimethyl-1; 2-benzanthracene; 9; Animal Studies; Animals; Anticarcinogenic Agents/*therapeutic use; Apoptosis; Apoptosis/*drug effects; Breast Neoplasms – Mortality; Breast Neoplasms – Prevention and Control; Breast Neoplasms – Risk Factors; Cell Physiology; Cell Proliferation/*drug effects; Diet – Evaluation; Experimental/pathology/*prevention & control; Female; Funding Source; Gene Expression Regulation; Genes; Human; Immunohistochemistry; Mammary Neoplasms; Mutation; National Institutes of Health (U.S.); Neoplasms – Prevention and Control; Phytotherapy; Pomegranate; Proto-Oncogene Proteins c-bcl-2/analysis; Rats; Sprague-Dawley; Tamoxifen; United States
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Mandal Animesh; Bhattacharyya Piyali; Bhatia Deepak
Description
An account of the resource
Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of its various health benefits. This study was initiated to investigate chemopreventive potential of a pomegranate emulsion (PE) against 7,12-dimethylbenz(a)anthracene (DMBA) rat mammary carcinogenesis. The animals were orally administered with PE (0.2-5.0 g/kg), starting 2 wk before and 16 wk following DMBA treatment. PE exhibited a striking reduction of DMBA-induced mammary tumor incidence, total tumor burden, and reversed histopathological changes. PE dose-dependently suppressed cell proliferation and induced apoptosis in mammary tumors. Immunohistochemical studies showed that PE increased intratumor Bax, decreased Bcl2 and manifested a proapoptotic shift in Bax/Bcl2 ratio. In addition, our gene expression study showed PE-mediated upregulation of Bad, caspase-3, caspase-7, caspase-9, poly (ADP ribose) polymerase and cytochrome c in mammary tumors. Thus, PE exerts chemoprevention of mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis mediated through upregulation of Bax and downregulation of Bcl2 in concert with caspase cascades. Pomegranate bioactive phytoconstituents could be developed as a chemopreventive drug to reduce the risk of breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">10.1080/01635581.2016.1115094</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Punicaceae/chemistry
10-Dimethyl-1
2-benzanthracene
2016
9
Animal Studies
Animals
Anticarcinogenic Agents/*therapeutic use
Apoptosis
Apoptosis/*drug effects
Bhatia Deepak
Bhattacharyya Piyali
Bishayee Anupam
Breast Neoplasms – Mortality
Breast Neoplasms – Prevention and Control
Breast Neoplasms – Risk Factors
Cell Physiology
Cell Proliferation/*drug effects
Diet – Evaluation
Experimental/pathology/*prevention & control
Female
Funding Source
Gene Expression Regulation
Genes
Human
Immunohistochemistry
Mammary Neoplasms
Mandal Animesh
Mutation
National Institutes of Health (U.S.)
Neoplasms – Prevention and Control
Nutrition and cancer
Phytotherapy
Pomegranate
Proto-Oncogene Proteins c-bcl-2/analysis
Rats
Sprague-Dawley
Tamoxifen
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/01635581.2013.767367" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/01635581.2013.767367</a>
Pages
329–344
Issue
3
Volume
65
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer.
Publisher
An entity responsible for making the resource available
Nutrition and cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-07
Subject
The topic of the resource
*Anticarcinogenic Agents; Animal; Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Biological Markers; Carcinoma; Catechin/administration & dosage/analogs & derivatives; Chemoprevention; Disease Models; Hepatocellular – Physiopathology; Hepatocellular – Prevention and Control; Hepatocellular – Therapy; Human; Humans; In Vitro Studies; In Vivo Studies; Liver Neoplasms/*drug therapy/*prevention & control; Mice; Neoplasms – Prevention and Control; Nutrition; Outcomes (Health Care); Phenols – Therapeutic Use; Polyphenols/*administration & dosage/pharmacology; Tea – Therapeutic Use; Tea/*chemistry; Xenograft Model Antitumor Assays
Creator
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Darvesh Altaf S; Bishayee Anupam
Description
An account of the resource
The prophylactic and therapeutic properties of tea have been attributed to green tea catechins and black tea theaflavins besides several other polyphenolic compounds. Tea polyphenols possess potent antioxidant and antiinflammatory properties and modulate several signaling pathways. These biochemical facets of tea polyphenols are responsible for its anticancer properties. Several lethal cancers, such as liver cancer, develop within a background of oxidative stress and inflammation. Liver cancer, also known as hepatocellular carcinoma (HCC), has been shown to occur throughout the world including Asia, Africa, Western Europe, and the United States. Phytochemicals, such as tea polyphenols, provide an effective and promising alternative for the chemoprevention and treatment of HCC. In this article, we systematically review, for the first time, the effects of tea polyphenols in the preclinical in vitro and in vivo HCC models. The review also examines, in critical detail, the biochemical mechanisms involved in the chemopreventive and antineoplastic effects of tea polyphenols in hepatic cancer. Finally, we highlight the role of synergy, bioavailability and pharmacokinetics of tea polyphenols, current status of clinical trials, discuss future directions, and comment on the future challenges involved in the effective use of tea polyphenols for the prevention and management of liver cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/01635581.2013.767367" target="_blank" rel="noreferrer noopener">10.1080/01635581.2013.767367</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Anticarcinogenic Agents
2013
Animal
Animals
Anti-Inflammatory Agents
Antioxidants
Biological Availability
Biological Markers
Bishayee Anupam
Carcinoma
Catechin/administration & dosage/analogs & derivatives
Chemoprevention
Darvesh Altaf S
Department of Pharmaceutical Sciences
Disease Models
Hepatocellular – Physiopathology
Hepatocellular – Prevention and Control
Hepatocellular – Therapy
Human
Humans
In Vitro Studies
In Vivo Studies
Liver Neoplasms/*drug therapy/*prevention & control
Mice
NEOMED College of Pharmacy
Neoplasms – Prevention and Control
nutrition
Nutrition and cancer
Outcomes (Health Care)
Phenols – Therapeutic Use
Polyphenols/*administration & dosage/pharmacology
Tea – Therapeutic Use
Tea/*chemistry
Xenograft Model Antitumor Assays
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.canlet.2010.01.030" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.canlet.2010.01.030</a>
Pages
1–12
Issue
1
Volume
294
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence.
Publisher
An entity responsible for making the resource available
Cancer letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-08
Subject
The topic of the resource
10-Dimethyl-1; 2-benzanthracene; 9; Animal; Animals; Biological; Breast Neoplasms – Chemically Induced; Breast Neoplasms – Diagnosis; Breast Neoplasms – Drug Therapy; Cell Division – Drug Effects; Cell Division/drug effects; Disease Models; Experimental/chemically induced/diagnosis/drug therapy; Experimental/drug therapy/pathology; Female; Glioblastoma/drug therapy; Glioma – Drug Therapy; Heterologous; Humans; Hydrocarbons; Male; Mammary Neoplasms; Metals; Metals – Diagnostic Use; Metals – Therapeutic Use; Models; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplasms – Diagnosis; Neoplasms – Drug Therapy; Neoplasms – Pathology; Neoplasms – Prevention and Control; Neoplasms/*diagnosis/drug therapy/prevention & control; Organometallic Compounds – Therapeutic Use; Organometallic Compounds/therapeutic use; Rats; Trace Elements – Diagnostic Use; Trace Elements – Therapeutic Use; Trace Elements/therapeutic use; Transplantation; Vanadium Compounds; Vanadium Compounds – Therapeutic Use; Vanadium Compounds/therapeutic use/toxicity; Vanadium/*therapeutic use/toxicity; Xenografts
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Waghray Abhijeet; Patel Mehool A; Chatterjee Malay
Description
An account of the resource
Vanadium, a dietary micronutrient, is yet to be established as an essential part of the human diet. Over the past century, several biological effects of vanadium, such as insulin-mimetic action as well as amelioration of hyperlipidemia and hypertension, have been discovered. This transition element is known to influence a battery of enzymatic systems, namely phosphatases, ATPases, peroxidases, ribonucleases, protein kinases and oxidoreductases. Multiple biochemical and molecular actions of vanadium have been implicated in its inhibitory effects on various tumor cells of human origin. Successful in vitro studies over the past few decades have advanced the anticancer research on vanadium into the preclinical stage. Vanadium in several animal cancer models provides protection against all stages of carcinogenesis–initiation, promotion, and progression. This review focuses on the current advances in cancer prevention and treatment as well as early detection by vanadium compounds in preclinical animal models while pointing to possible mechanisms of such diverse beneficial effects. Clinical pharmacokinetic and potential toxicity studies on vanadium are also highlighted in this review. Supporting and challenging evidence as well as future directions of vanadium research exploring the possibility of using this dietary agent for detection, prevention and treatment of human cancers are critically discussed.
Identifier
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<a href="http://doi.org/10.1016/j.canlet.2010.01.030" target="_blank" rel="noreferrer noopener">10.1016/j.canlet.2010.01.030</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene
2010
9
Animal
Animals
Biological
Bishayee Anupam
Breast Neoplasms – Chemically Induced
Breast Neoplasms – Diagnosis
Breast Neoplasms – Drug Therapy
Cancer letters
Cell Division – Drug Effects
Cell Division/drug effects
Chatterjee Malay
Disease Models
Experimental/chemically induced/diagnosis/drug therapy
Experimental/drug therapy/pathology
Female
Glioblastoma/drug therapy
Glioma – Drug Therapy
Heterologous
Humans
Hydrocarbons
Male
Mammary Neoplasms
Metals
Metals – Diagnostic Use
Metals – Therapeutic Use
Models
Neoplasm Staging
Neoplasm Transplantation
Neoplasms
Neoplasms – Diagnosis
Neoplasms – Drug Therapy
Neoplasms – Pathology
Neoplasms – Prevention and Control
Neoplasms/*diagnosis/drug therapy/prevention & control
Organometallic Compounds – Therapeutic Use
Organometallic Compounds/therapeutic use
Patel Mehool A
Rats
Trace Elements – Diagnostic Use
Trace Elements – Therapeutic Use
Trace Elements/therapeutic use
Transplantation
Vanadium Compounds
Vanadium Compounds – Therapeutic Use
Vanadium Compounds/therapeutic use/toxicity
Vanadium/*therapeutic use/toxicity
Waghray Abhijeet
Xenografts