1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
207–211
Issue
2
Volume
345
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition of striatal dopamine transporter activity by 17beta-estradiol.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-03
Subject
The topic of the resource
Female; Animals; Rats; Dopamine/metabolism; Neostriatum/*drug effects/metabolism; Dopamine Plasma Membrane Transport Proteins; *Membrane Glycoproteins; *Nerve Tissue Proteins; Estradiol/*pharmacology; *Membrane Transport Proteins; Carrier Proteins/*antagonists & inhibitors; Synaptosomes/*drug effects/metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Disshon K A; Boja J W; Dluzen D E
Description
An account of the resource
Striatal synaptosomes from ovariectomized rats were prepared to examine the effect of 17beta-estradiol on [3H]dopamine uptake. Estradiol inhibited [3H]dopamine uptake in a dose-dependent manner, with an IC50 of 7.2 microM. Use of identical concentrations of progesterone had no effect on [3H]dopamine uptake. The effects of estradiol were exerted by decreasing the affinity of the transporter for dopamine, as revealed by a dose-dependent increase in the Km. The Km values for 0 (control), 10, and 100 microM estradiol were 108+/-11 258+/-44 and 415+/-40 nM, respectively, with each of the three concentrations tested being significantly different among each other. No statistically significant differences were obtained for the Vmax, with values for the three increasing doses being 9.2+/-0.8, 8.3+/-0.5 and 7.3+/-0.8 pmol/min per mg protein. These results demonstrate that estradiol, but not progesterone, inhibits striatal dopamine uptake by decreasing the affinity of the transporter for dopamine. Such a mechanism may serve as one of the bases for the modulatory effects of estradiol upon the nigrostriatal dopaminergic system.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Membrane Glycoproteins
*Membrane Transport Proteins
*Nerve Tissue Proteins
1998
Animals
Boja J W
Carrier Proteins/*antagonists & inhibitors
Disshon K A
Dluzen D E
Dopamine Plasma Membrane Transport Proteins
Dopamine/metabolism
Estradiol/*pharmacology
European journal of pharmacology
Female
Neostriatum/*drug effects/metabolism
Rats
Sprague-Dawley
Synaptosomes/*drug effects/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000095338</a>
Pages
295–302
Issue
5
Volume
83
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Androgens/administration & dosage; Animals; Dopamine Agents/*administration & dosage/toxicity; Dopamine/metabolism; Dose-Response Relationship; Drug; Drug Administration Schedule; Estradiol/administration & dosage/*analogs & derivatives/physiology; Estrogen Antagonists/administration & dosage; Female; Methamphetamine/*administration & dosage/toxicity; Mice; Neostriatum/*drug effects/metabolism; Nerve Degeneration/chemically induced/prevention & control; Neuroprotective Agents/administration & dosage; Neurotoxins/*administration & dosage; Ovariectomy; Parkinson Disease/physiopathology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/administration & dosage
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agents–tamoxifen (TMX, 12.5 microg), testosterone (5 microg) and dehydroepiandrosterone (DHEA, 3 mg) in this paradigm. In experiment 1, ovariectomized mice received an initial treatment with MA. At 1 week after MA, mice were treated with EB, TMX, testosterone, DHEA or oil vehicle and 24 h later a second MA treatment. Striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations in the MA-treated groups were decreased compared to the non-MA-treated control. Neither EB nor any of the other agents tested showed enhanced neurodegenerative or neuroprotective effects against a second MA invasion. To verify that estrogen was capable of showing a neuroprotective effect under a condition of two administrations of MA, in experiment 2, EB was administered either once or twice prior to each of the two MA treatments. EB treatment prior to the first MA invasion or first and second MA protected the NSDA system against DA and DOPAC depletion. These results imply that a lower dose of EB, TMX, testosterone and DHEA cannot exert neurodegenerative or neuroprotective effects in the impaired NSDA model. However, EB administered prior to the introduction of neurotoxicity can protect the NSDA system. This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">10.1159/000095338</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Androgens/administration & dosage
Animals
Dluzen Dean E
Dopamine Agents/*administration & dosage/toxicity
Dopamine/metabolism
Dose-Response Relationship
Drug
Drug Administration Schedule
Estradiol/administration & dosage/*analogs & derivatives/physiology
Estrogen Antagonists/administration & dosage
Female
Liu Bin
Methamphetamine/*administration & dosage/toxicity
Mice
Neostriatum/*drug effects/metabolism
Nerve Degeneration/chemically induced/prevention & control
Neuroendocrinology
Neuroprotective Agents/administration & dosage
Neurotoxins/*administration & dosage
Ovariectomy
Parkinson Disease/physiopathology
Substantia Nigra/*drug effects/metabolism
Tamoxifen/administration & dosage
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000070278" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000070278</a>
Pages
232–238
Issue
4
Volume
77
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-04
Subject
The topic of the resource
Animals; Dopamine/metabolism; Female; Inbred Strains; Male; Messenger/drug effects; Methamphetamine/*toxicity; Mice; Neostriatum/*drug effects/metabolism; Neurodegenerative Diseases/*chemically induced/genetics; Neurotoxins/*toxicity; RNA; Sex Factors; Substantia Nigra/*drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Tweed Christopher; Anderson Linda I; Laping Nicholas J
Description
An account of the resource
In this report female and male CD-1 mice were treated with a neurotoxic regimen of methamphetamine (MA) to compare gender differences in striatal dopamine depletion and concordant changes in mRNA markers of the transforming growth factor-beta injury response associated with neurodegeneration. Striatal dopamine concentrations of MA-treated female mice were less depleted and significantly greater than that of identically treated males. Associated with this gender difference in striatal dopamine depletion were significantly decreased mRNA levels of plasminogen activator inhibitor-1 and a trend for increased (p = 0.06) mRNA levels of glial fibrillary acidic protein within females. No statistically significant differences between MA-treated female and male mice were obtained in mRNA levels for transforming growth factor-beta, transforming growth factor-beta type 2 receptor, activin-like kinase-5 or fibronectin. These data demonstrate the presence of changes in two specific molecular markers of the transforming growth factor-beta injury response which are in accordance with gender differences in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000070278" target="_blank" rel="noreferrer noopener">10.1159/000070278</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Anderson Linda I
Animals
Dluzen Dean E
Dopamine/metabolism
Female
Inbred Strains
Laping Nicholas J
Male
Messenger/drug effects
Methamphetamine/*toxicity
Mice
Neostriatum/*drug effects/metabolism
Neurodegenerative Diseases/*chemically induced/genetics
Neuroendocrinology
Neurotoxins/*toxicity
RNA
Sex Factors
Substantia Nigra/*drug effects/metabolism
Tweed Christopher