1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.20309</a> Pages 347–353 Issue 5 Volume 60 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Testosterone modulation of striatal dopamine output in orchidectomized mice. Publisher An entity responsible for making the resource available Synapse (New York, N.Y.) Date A point or period of time associated with an event in the lifecycle of the resource 2006 2006-10 Subject The topic of the resource Adrenergic Uptake Inhibitors/pharmacology; Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism/pharmacology; Male; Mice; Neural Pathways/drug effects/*metabolism; Orchiectomy; Potassium Chloride/pharmacology; Presynaptic Terminals/drug effects/metabolism; Reserpine/pharmacology; Sex Characteristics; Substantia Nigra/drug effects/*metabolism; Synaptic Transmission/drug effects/physiology; Synaptic Vesicles/drug effects/metabolism; Testosterone/*metabolism; Vesicular Monoamine Transport Proteins/drug effects/metabolism Creator An entity primarily responsible for making the resource Shemisa Kamal; Kunnathur Vidhya; Liu Bin; Salvaterra Ty J; Dluzen Dean E Description An account of the resource Three experiments are presented in which dopamine (DA) responses from superfused striatal tissue of orchidectomized (ORCH) mice treated or not with testosterone (T) are compared. In experiment 1, potassium-stimulated DA output was significantly greater in ORCH vs. ORCH+T mice. This profile was reversed when reserpine was infused in experiment 2, with DA output being significantly greater in ORCH+T vs. ORCH mice. In experiment 3, the amount of DA recovered following infusion of DA indicated no statistically significant differences in DA recoveries between ORCH and ORCH+T mice as tested in this paradigm. The findings that both potassium- and reserpine-induced DA responses are altered significantly by T suggests that one potential site of T action might involve the storage/uptake of DA within the vesicles of these neurons. Such results have important implications with regard to understanding the sex differences that are present in nigrostriatal dopaminergic function within health and diseased states. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">10.1002/syn.20309</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2006 Adrenergic Uptake Inhibitors/pharmacology Animals Corpus Striatum/drug effects/*metabolism Dluzen Dean E Dopamine/*metabolism/pharmacology Kunnathur Vidhya Liu Bin Male Mice Neural Pathways/drug effects/*metabolism Orchiectomy Potassium Chloride/pharmacology Presynaptic Terminals/drug effects/metabolism Reserpine/pharmacology Salvaterra Ty J Sex Characteristics Shemisa Kamal Substantia Nigra/drug effects/*metabolism Synapse (New York, N.Y.) Synaptic Transmission/drug effects/physiology Synaptic Vesicles/drug effects/metabolism Testosterone/*metabolism Vesicular Monoamine Transport Proteins/drug effects/metabolism