1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-007-0017-0</a> Pages 809–817 Issue 6 Volume 115 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice. Publisher An entity responsible for making the resource available Journal of neural transmission (Vienna, Austria : 1996) Date A point or period of time associated with an event in the lifecycle of the resource 2008 2008-06 Subject The topic of the resource *Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/drug effects/*metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine Uptake Inhibitors/pharmacology; Dopamine/*metabolism; Down-Regulation/drug effects/genetics; Female; Gene Expression Regulation/drug effects/genetics; Heterozygote; Knockout; Male; Methamphetamine/pharmacology; Mice; Mutation/*genetics; Neural Pathways/drug effects/metabolism; Potassium Chloride/metabolism/pharmacology; Substantia Nigra/drug effects/metabolism; Synaptic Transmission/drug effects/genetics; Up-Regulation/drug effects/genetics Creator An entity primarily responsible for making the resource Ji Jing; Dluzen Dean E Description An account of the resource The issue of whether a deletion of the dopamine transporter (DAT) allele (+/- DAT) would differentially alter striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) concentrations and DA release upon potassium and methamphetamine (MA) stimulation between male and female mice was examined. Striatal DA and DOPAC concentrations of female +/- DAT mice were significantly decreased as compared with wild type (+/+) controls and male +/- DAT mice. No such changes were obtained from the olfactory tubercle suggesting that these effects might be specific for the striatum. Potassium-stimulated DA was increased in male and female +/- DAT mice and maximally stimulated DA was obtained from +/- DAT females, although these mice showed the lowest DA concentrations. MA-evoked DA was increased in male and female +/- mice. While MA-evoked DA was significantly increased in +/+ males versus +/+ females, the +/- females showed the highest DA responses, thereby showing a reversal in the results seen in wild-type conditions. These findings indicate: (1) that a deficiency in the DAT interacts with the sex of the subject, (2)+/- DAT females show more extreme changes in dopaminergic responses, and (3) the importance for considering such variables such as sex when examining differences among knock-out conditions. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">10.1007/s00702-007-0017-0</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Sex Characteristics 2008 3 4-Dihydroxyphenylacetic Acid/metabolism Animals Brain/drug effects/*metabolism Corpus Striatum/drug effects/*metabolism Dluzen Dean E Dopamine Plasma Membrane Transport Proteins/*genetics Dopamine Uptake Inhibitors/pharmacology Dopamine/*metabolism Down-Regulation/drug effects/genetics Female Gene Expression Regulation/drug effects/genetics Heterozygote Ji Jing Journal of neural transmission (Vienna, Austria : 1996) Knockout Male Methamphetamine/pharmacology Mice Mutation/*genetics Neural Pathways/drug effects/metabolism Potassium Chloride/metabolism/pharmacology Substantia Nigra/drug effects/metabolism Synaptic Transmission/drug effects/genetics Up-Regulation/drug effects/genetics