1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0197-0186(97)00086-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0197-0186(97)00086-7</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
299-307
Issue
3
Volume
32
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen alters dopamine output through direct actions upon superfused corpus striatal tissue fragments
Publisher
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Neurochemistry International
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-03
Subject
The topic of the resource
breast-cancer; receptor; Biochemistry & Molecular Biology; Neurosciences & Neurology; estrogen; breast-cancer; antagonist; estradiol; nigrostriatal; release; anti-estrogen; antiestrogens; metabolites; brain metastases; sexual-behavior; non-genomic
Creator
An entity primarily responsible for making the resource
McDermott J L; Anderson L I; Dluzen D E
Description
An account of the resource
Tamoxifen (10 pg/ml) was infused directly into superfused striatal tissue fragments of ovariectomized rats for a 50 min period. Immediately following the termination of tamoxifen there was a significant increase in dopamine output compared with non-infused controls. No such significant increase was observed with use of a 100 pg/ml tamoxifen dose. Although dopamine output was again increased upon termination of a 2 h infusion of tamoxifen, these levels failed to differ significantly from that of non-infused controls. Similarly, a shorter 10 min duration infusion of tamoxifen failed to alter dopamine output. Finally, we examined whether the tamoxifen-induced, post-infusion increase in dopamine output, as observed following a 50 min infusion of 10 pg/ml, involved a calcium dependent process. To achieve this goal, superfusions were performed with Calcium/Tamoxifen, No Calcium/Tamoxifen, No Calcium/No Tamoxifen and Calcium/No Tamoxifen. A significant increase in dopamine output post-tamoxifen infusion was obtained for the Calcium/Tamoxifen condition compared with the remaining three groups which failed to differ from one another. Taken together these results show that tamoxifen can alter dopamine output through direct, non-genomic effects upon striatal neurons. Responses to this anti-estrogen are intriguing since they are apparent following removal, but not during tamoxifen infusion and represent a calcium-dependent process. These data suggest that tamoxifen may represent an important modulator of nigrostriatal dopaminergic function. (C) 1998 Elsevier Science Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0197-0186(97)00086-7" target="_blank" rel="noreferrer noopener">10.1016/s0197-0186(97)00086-7</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
Anderson L I
Antagonist
anti-estrogen
antiestrogens
Biochemistry & Molecular Biology
brain metastases
breast-cancer
Dluzen D E
estradiol
estrogen
Journal Article or Conference Abstract Publication
McDermott J L
metabolites
Neurochemistry international
Neurosciences & Neurology
nigrostriatal
non-genomic
Receptor
release
sexual-behavior
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0197-0186(86)90084-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0197-0186(86)90084-7</a>
Pages
423–429
Issue
3
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Metergoline, pirenperone and pizotifen alter dopamine and 5-hydroxytryptamine synthesis in discrete rat brain nuclei.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
1905-6
Creator
An entity primarily responsible for making the resource
Nielsen J A
Description
An account of the resource
The effects of the 5-hydroxytryptamine receptor antagonists metergoline, pirenperone and pizotifen on 5-hydroxytryptamine and dopamine synthesis were determined by measuring the rate of accumulation of 5-hydroxytryptamine and 3,4-dihydroxyphenylalanine, respectively, after administering l-tryptophan and m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid decarboxylase.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0197-0186(86)90084-7" target="_blank" rel="noreferrer noopener">10.1016/0197-0186(86)90084-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1986
Neurochemistry international
Nielsen J A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0197-0186(86)90032-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0197-0186(86)90032-x</a>
Pages
61–67
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of chronic antidepressant treatment on nigrostriatal and mesolimbic dopamine autoreceptors in the rat.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
1905-06
Creator
An entity primarily responsible for making the resource
Nielsen J A
Description
An account of the resource
Dopamine autoreceptors were studied by determining the effects of chronic antidepressant treatment on the ability of several doses of apomorphine to decrease 3,4-dihydroxyphenylalanine accumulation (an index of dopamine synthesis in vivo) after saline or ?-hydroxybutyric acid lactone (?-butyrolactone). 3,4-Dihydroxyphenylalanine accumulation was measured in nigrostriatal [nucleus caudatus putamen] and mesolimbic [nucleus accumbens and tuberculum olfactorium] nerve terminals. Apomorphine decreased 3,4-dihydroxyphenylalanine accumulation in the nucleus caudatus putamen, tuberculum olfactorium and nucleus accumbens in a dose-related manner. Chronic imipramine (10 days) treatment attenuated the low and high dose apomorphine-induced decrease in 3,4-dihydroxyphenylalanine accumulation in the nucleus caudatus putamen to a greater extent than the tuberculum olfactorium or nucleus accumbens. In ?-butyrolactone-treated animals chronic treatment with imipramine, amitriptyline or bupropion (10 days) attenuated the low dose apomorphine effect in the nucleus caudatus putamen, but not the tuberculum olfactorium or nucleus accumbens. Only 2 days of imipramine treatment had no effect on the apomorphine-induced decrease in 3,4-dihydroxyphenylalanine accumulation in the nucleus caudatus putamen with or without ?-butyrolactone treatment. These data suggest that chronic treatment with three antidepressants produces dopamine autoreceptor subsensitivity in nigrostriatal neurons more than mesolimbic neurons and that this effect is not seen with short-term imipramine treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0197-0186(86)90032-x" target="_blank" rel="noreferrer noopener">10.1016/0197-0186(86)90032-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1986
Neurochemistry international
Nielsen J A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0197-0186(86)90014-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0197-0186(86)90014-8</a>
Pages
403–412
Issue
3
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chlorimipramine, fenfluramine and quipazine decrease 5-hydroxytryptamine synthesis in discrete rat brain nuclei.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
1905-6
Creator
An entity primarily responsible for making the resource
Nielsen J A
Description
An account of the resource
A procedure for studying 5-hydroxytryptamine synthesis by determining the rate of accumulation of 5-hydroxytryptophan after administering m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid decarboxylase, and large doses of l-tryptophan was characterized. The utility of this method as an index of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0197-0186(86)90014-8" target="_blank" rel="noreferrer noopener">10.1016/0197-0186(86)90014-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1986
Neurochemistry international
Nielsen J A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuint.2012.03.013</a>
Pages
806–808
Issue
8
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Drug Synergism; Inbred C57BL; Indoles/*pharmacology; Methamphetamine/*pharmacology; Mice
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Darvesh Altaf S; Dluzen Dean E
Description
An account of the resource
Dimebon is an anti-histamine with central nervous system activity. In this report the effects of dimebon as a neuroprotectant in animal models of Parkinson's disease were tested as assessed in methamphetamine- and MPTP-induced striatal dopaminergic toxicity. Dimebon (1mg/kg) administered at 30 min prior to methamphetamine (40mg/kg) significantly reduced the amount of striatal dopamine depletion in mice, without altering the initial methamphetamine-induced increase in body temperature. In contrast, dimebon at either 1 or 25mg/kg administered at 30 min prior to MPTP (35 mg/kg) was unable to prevent MPTP-induced striatal dopamine loss as determined at 7 days post-methamphetamine/MPTP. These data suggest that dimebon may be exerting a neurotoxin specific neuroprotective effect upon the striatal dopaminergic system and may serve as an important tool for discriminating the mechanistic basis of these two dopaminergic neurotoxins.
Identifier
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<a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">10.1016/j.neuint.2012.03.013</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Corpus Striatum/*drug effects/metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Dluzen Dean E
Dopamine/*metabolism
Drug Synergism
Geldenhuys Werner J
Inbred C57BL
Indoles/*pharmacology
Methamphetamine/*pharmacology
Mice
NEOMED College of Pharmacy
Neurochemistry international
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuint.2011.04.005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuint.2011.04.005</a>
Pages
101–103
Issue
2
Volume
59
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Parity decreases methamphetamine-induced striatal dopaminergic perturbation.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
*Parity; Animals; Corpus Striatum/*drug effects/metabolism/physiology; Dopamine/*metabolism; Female; Methamphetamine/*pharmacology; Mice; Pregnancy
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The role of parity upon methamphetamine-induced neurotoxicity of the striatal dopaminergic system was assessed. Female CD-1 mice either remained nulliparous or underwent one or three complete pregnancies and were designated as the 0, 1 or 3 pregnancy groups. The mice were then treated with a neurotoxic regimen of methamphetamine (MA–40 mg/kg) or its saline vehicle (control) and striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels were measured at
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuint.2011.04.005" target="_blank" rel="noreferrer noopener">10.1016/j.neuint.2011.04.005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Parity
2011
Animals
Corpus Striatum/*drug effects/metabolism/physiology
Dluzen Dean E
Dopamine/*metabolism
Female
Methamphetamine/*pharmacology
Mice
Neurochemistry international
Pregnancy