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Text
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URL Address
<a href="http://doi.org/10.1016/0091-3057(95)02275-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(95)02275-9</a>
Pages
491–494
Issue
2
Volume
54
Dublin Core
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Title
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Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine.
Publisher
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Pharmacology, biochemistry, and behavior
Date
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1996
1996-06
Subject
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Animals; Cocaine/*analogs & derivatives/pharmacology; Convulsants/*pharmacology; Dopamine Uptake Inhibitors/*pharmacology; Drug Interactions; Epilepsy; Female; Inbred Strains; Kindling; Male; Mice; Neurologic/*drug effects; Seizures/*chemically induced; Status Epilepticus/chemically induced; Tonic-Clonic/chemically induced
Creator
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Meehan S M; Schechter M D
Description
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Sensitization and cross-sensitization to the seizurogenic effects of cocaine and cocaethylene were examined in the HS strain of mice. Animals were administered IP injections of either 48 mg/kg cocaine or 32 mg/kg cocaethylene once per day for 4 days. On the fifth day, mice were injected with either the same drug that was administered on days 1-4 or the alternative psychostimulant and the occurrence of seizure activity was recorded. Repeated cocaine administration resulted in the induction of tonic-clonic seizures and status epilepticus in 90% of the animals tested with cocaine on the fifth day. A similar increase in seizure prevalence, noted as a kindling effect, was observed in cocaethylene-treated animals tested with cocaethylene in that 90% of the mice exhibited status epilepticus on the last test day. Significant cross-sensitization was observed only in the group that received cocaethylene following repeated cocaine exposure. However, data obtained from animals injected with cocaine following cocaethylene treatment also were suggestive of cross-sensitization effects. Results are discussed in terms of the potential mechanistic differences between cocaine and its ethanol-derived product, as well as its relevance to cocaine use/abuse.
Identifier
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<a href="http://doi.org/10.1016/0091-3057(95)02275-9" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(95)02275-9</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Cocaine/*analogs & derivatives/pharmacology
Convulsants/*pharmacology
Dopamine Uptake Inhibitors/*pharmacology
Drug Interactions
Epilepsy
Female
Inbred Strains
Kindling
Male
Meehan S M
Mice
Neurologic/*drug effects
Pharmacology, biochemistry, and behavior
Schechter M D
Seizures/*chemically induced
Status Epilepticus/chemically induced
Tonic-Clonic/chemically induced