1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(90)91198-p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(90)91198-p</a>
Pages
53–61
Issue
1
Volume
506
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of extracellular potassium concentration and postsynaptic membrane potential on calcium-induced potentiation in area CA1 of rat hippocampus.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-01
Subject
The topic of the resource
Animals; Rats; Action Potentials/drug effects; Membrane Potentials/drug effects; Potassium/*pharmacology; Hippocampus/drug effects/*physiology; Neuronal Plasticity/*drug effects; Calcium/*pharmacology
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
Long-lasting potentiation can be induced in area CA1 of hippocampus by a relatively brief (7-10 min) exposure to a higher (4.0 mM) than normal (2.0 mM) extracellular calcium concentration. We have found that long-lasting calcium-induced potentiation is dependent on extracellular potassium concentration. Slices exposed to high extracellular calcium in the presence of normal extracellular potassium (3.35 mM) showed a transient facilitation. Long-lasting potentiation was induced by exposure to high calcium only in slices also exposed to higher than normal extracellular potassium (6.25 mM). In intracellular experiments we found that injection of depolarizing current into postsynaptic neurons could substitute for high extracellular potassium. These results suggest that calcium-induced potentiation involves a postsynaptic, voltage-dependent mechanism. A similar conclusion has been reached for tetanus-induced potentiation. We also found that calcium-induced potentiation, like tetanus-induced potentiation, is not accompanied by an increase in postsynaptic input resistance.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(90)91198-p" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)91198-p</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Action Potentials/drug effects
Animals
Brain research
Calcium/*pharmacology
Grover L M
Hippocampus/drug effects/*physiology
Membrane Potentials/drug effects
Neuronal Plasticity/*drug effects
Potassium/*pharmacology
Rats
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(90)90603-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(90)90603-7</a>
Pages
309–314
Issue
3
Volume
113
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-06
Subject
The topic of the resource
Animals; Action Potentials/drug effects; Electric Stimulation; In Vitro Techniques; Hippocampus/drug effects/*physiology; 2-Amino-5-phosphonovalerate/*pharmacology; Neuronal Plasticity/*drug effects; Calcium/*pharmacology; Receptors; N-Methyl-D-Aspartate; Neurotransmitter/antagonists & inhibitors/*physiology
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent, post-synaptic mechanisms. Tetanus-induced long-term potentiation (LTP) was blocked by 50 microM D,L-2-amino-5-phosphonovalerate (APV) as previously reported by others. In contrast, Ca2(+)-induced long-lasting potentiation was not reduced by 50 microM APV. Thus the mechanisms by which tetanic stimulation and exposure to high Ca2+ induce synaptic potentiation may differ.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(90)90603-7" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(90)90603-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
2-Amino-5-phosphonovalerate/*pharmacology
Action Potentials/drug effects
Animals
Calcium/*pharmacology
Electric Stimulation
Grover L M
Hippocampus/drug effects/*physiology
In Vitro Techniques
N-Methyl-D-Aspartate
Neuronal Plasticity/*drug effects
Neuroscience letters
Neurotransmitter/antagonists & inhibitors/*physiology
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/toxsci/11.1.221" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/toxsci/11.1.221</a>
Pages
221–228
Issue
2
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aspartame exposure and in vitro hippocampal slice excitability and plasticity.
Publisher
An entity responsible for making the resource available
Fundamental and applied toxicology : official journal of the Society of Toxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-08
Subject
The topic of the resource
Female; Time Factors; Animals; Rats; Electric Stimulation; Electrophysiology; Neurons/drug effects; Aspartame/*toxicity; Dipeptides/*toxicity; Hippocampus/*drug effects/physiopathology; Neuronal Plasticity/*drug effects
Creator
An entity primarily responsible for making the resource
Fountain S B; Hennes S K; Teyler T J
Description
An account of the resource
Aspartame (APM) is a low-calorie sweetener recently approved and released for widespread use in the United States. However, concerns still exist that APM consumption may be responsible for adverse neurological and psychological effects in some people. In addition, recent reports indicate that APM exposure may alter regional brain neurotransmitter levels. The present study assessed the effects of APM and its amino acid moieties on rat hippocampal slice excitability and plasticity. Specifically, tests of excitatory systems, inhibitory systems, and synaptic plasticity (induction of long-term potentiation–LTP) were administered postexposure. Exposures of 0.01, 0.1, 1, and 10 mM APM potentiated the response of hippocampal CA1 pyramidal cells, but had no apparent effect on local inhibitory systems. APM exposure did not block the establishment of LTP at any dose despite the potentiation of pyramidal cell response observed postexposure. In addition, 0.1 mM phenylalanine (PHE) produced a greater increase in excitability than that produced by an equivalent dose of APM, 0.1 mM aspartic acid (ASP) and 0.1 mM phenylalanine methyl ester (PM) produced effects comparable to those produced a smaller, but reliable, change in hippocampal CA1 excitability relative to baseline. Like APM, none of the amino acids produced detectable changes in inhibitory systems or neuronal plasticity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/toxsci/11.1.221" target="_blank" rel="noreferrer noopener">10.1093/toxsci/11.1.221</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Aspartame/*toxicity
Dipeptides/*toxicity
Electric Stimulation
Electrophysiology
Female
Fountain S B
Fundamental and applied toxicology : official journal of the Society of Toxicology
Hennes S K
Hippocampus/*drug effects/physiopathology
Neuronal Plasticity/*drug effects
Neurons/drug effects
Rats
Teyler T J
Time Factors