1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/347477a0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/347477a0</a>
Pages
477–479
Issue
6292
Volume
347
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Two components of long-term potentiation induced by different patterns of afferent activation.
Publisher
An entity responsible for making the resource available
Nature
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-10
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/*pharmacology; Afferent Pathways/physiology; Animals; Calcium/*physiology; Hippocampus/*physiology; In Vitro Techniques; Membrane Potentials; Memory/*physiology; N-Methyl-D-Aspartate/*physiology; Neuronal Plasticity; Receptors; Synaptic Transmission; Time Factors
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/347477a0" target="_blank" rel="noreferrer noopener">10.1038/347477a0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
2-Amino-5-phosphonovalerate/*pharmacology
Afferent Pathways/physiology
Animals
Calcium/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Membrane Potentials
Memory/*physiology
N-Methyl-D-Aspartate/*physiology
Nature
Neuronal Plasticity
Receptors
Synaptic Transmission
Teyler T J
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(88)91478-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(88)91478-3</a>
Pages
222–229
Issue
1
Volume
439
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A critical period for long-term potentiation in the developing rat visual cortex.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-01
Subject
The topic of the resource
Animals; Rats; Aging; Electric Stimulation; In Vitro Techniques; Neuronal Plasticity; Visual Cortex/*growth & development/physiology; Newborn
Creator
An entity primarily responsible for making the resource
Perkins A T 4th; Teyler T J
Description
An account of the resource
The in vitro rodent visual cortical slice preparation demonstrates a critical period for long-term potentiation (LTP). Current source density (CSD) analysis reveals peak potentiation of both supra-(layers II-III) and infragranular (layers V) layers of visual cortex during the second postnatal week following stimulation of the subadjacent white matter. By day 30 both the supra- and infragranular CSD sinks show only minimal potentiation. In adults there is no change in supragranular response but infragranular layers reveal 177% potentiation. Therefore, we conclude that rodent visual cortex displays a critical period for maximum plasticity of both supra and infra-granular layers. Supragranular visual cortex plasticity ends by day 30 whereas infragranular layers retain plastic qualities into adulthood.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(88)91478-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(88)91478-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Aging
Animals
Brain research
Electric Stimulation
In Vitro Techniques
Neuronal Plasticity
Newborn
Perkins A T 4th
Rats
Teyler T J
Visual Cortex/*growth & development/physiology