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Text
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<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90801-v</a>
Pages
129–131
Issue
1
Volume
203
Dublin Core
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Title
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Cholinergic disinhibition in area CA1 of the rat hippocampus is not mediated by receptors located on inhibitory neurons.
Publisher
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European journal of pharmacology
Date
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1991
1991-10
Subject
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2-Amino-5-phosphonovalerate/pharmacology; Action Potentials/drug effects; Adenosine/pharmacology; Animals; Baclofen/pharmacology; Carbachol/pharmacology; Cholinergic/*drug effects; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; Hippocampus/*drug effects; In Vitro Techniques; Membrane Potentials/drug effects; Neurons/*drug effects; Parasympathetic Nervous System/*drug effects; Phorbol Esters/pharmacology; Quinoxalines/pharmacology; Rats; Receptors; Synaptic Transmission/physiology
Creator
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Lambert N A; Teyler T J
Description
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We studied the effects of carbamylcholine (carbachol; CCh) on monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). CCh (30 microM) blocked late afterhyperpolarizations but did not depress GABAA receptor-mediated fast monosynaptic IPSPs or GABAB receptor-mediated late monosynaptic IPSPs. In the presence of CCh the GABAB receptor agonist (+/- )-baclofen (2 microM) reversibly hyperpolarized pyramidal neurons and depressed monosynaptic IPSPs as under control conditions. Phorbol-12,13-diacetate (PDAc; 10 microM) increased fast and depressed late monosynaptic IPSPs, and prevented depression of IPSPs by baclofen. These results suggest that cholinergic disinhibition in area CA1 of the hippocampus results from decreased synaptic excitation of inhibitory neurons.
Identifier
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<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90801-v</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Action Potentials/drug effects
Adenosine/pharmacology
Animals
Baclofen/pharmacology
Carbachol/pharmacology
Cholinergic/*drug effects
European journal of pharmacology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
Hippocampus/*drug effects
In Vitro Techniques
Lambert N A
Membrane Potentials/drug effects
Neurons/*drug effects
Parasympathetic Nervous System/*drug effects
Phorbol Esters/pharmacology
Quinoxalines/pharmacology
Rats
Receptors
Synaptic Transmission/physiology
Teyler T J