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Text
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URL Address
<a href="http://doi.org/10.1007/s004410051211" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s004410051211</a>
Pages
43–54
Issue
1
Volume
295
Dublin Core
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Title
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Vagal afferents from the uterus and cervix provide direct connections to the brainstem.
Publisher
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Cell and tissue research
Date
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1999
1999-01
Subject
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Animals; Brain Stem/*anatomy & histology; Cervix Uteri/*innervation; Estrogen/metabolism; Female; Immunohistochemistry; Neurons/cytology/metabolism; Rats; Receptors; Sprague-Dawley; Uterus/*innervation; Vagus Nerve/*anatomy & histology/metabolism
Creator
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Collins J J; Lin C E; Berthoud H R; Papka R E
Description
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Previous anatomical studies demonstrated vagal innervation to the ovary and distal colon and suggested the vagus nerve has uterine inputs. Recent behavioral and physiological evidence indicated that the vagus nerves conduct sensory information from the uterus to the brainstem. The present study was undertaken to identify vagal sensory connections to the uterus. Retrograde tracers, Fluorogold and pseudorabies virus were injected into the uterus and cervix. DiI, an anterograde tracer, was injected into the nodose ganglia. Neurectomies involving the pelvic, hypogastric, ovarian and abdominal vagus nerves were performed, and then uterine whole-mounts examined for sensory nerves containing calcitonin gene-related peptide. Nodose ganglia and caudal brainstem sections were examined for the presence of estrogen receptor-containing neurons in "vagal locales." Labeling of uterine-related neurons in the nodose ganglia (Fluorogold and pseudorabies virus) and in the brainstem nuclei (pseudorabies virus) was obtained. DiI-labeled nerve fibers occurred near uterine horn and uterine cervical blood vessels, in the myometrium, and in paracervical ganglia. Rats with vagal, pelvic, hypogastric and ovarian neurectomies exhibited a marked decrease in calcitonin gene-related peptide-immunoreactive nerves in the uterus relative to rats with pelvic, hypogastric, and ovarian neurectomies with intact vagus nerves. Neurons in the nodose ganglia and nucleus tractus solitarius were immunoreactive for estrogen receptors. These results demonstrated: (1) the vagus nerves serve as connections between the uterus and CNS, (2) the nodose ganglia contain uterine-related vagal afferent neuron cell bodies, and (3) neurons in vagal locales contain estrogen receptors.
Identifier
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<a href="http://doi.org/10.1007/s004410051211" target="_blank" rel="noreferrer noopener">10.1007/s004410051211</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animals
Berthoud H R
Brain Stem/*anatomy & histology
Cell and tissue research
Cervix Uteri/*innervation
Collins J J
Estrogen/metabolism
Female
Immunohistochemistry
Lin C E
Neurons/cytology/metabolism
Papka R E
Rats
Receptors
Sprague-Dawley
Uterus/*innervation
Vagus Nerve/*anatomy & histology/metabolism