1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/jneurosci.22-23-10449.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/jneurosci.22-23-10449.2002</a>
Pages
10449–10460
Issue
23
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Projection to the inferior colliculus from the basal nucleus of the amygdala.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
Animals; Acoustic Stimulation/methods; Species Specificity; Action Potentials/physiology; Amygdala/*cytology/physiology; Dextrans; Rhodamines; Fluorescent Dyes; *Stilbamidines; Auditory Cortex/cytology; Auditory Pathways/*cytology/physiology; Axonal Transport/physiology; Brain Stem/cytology; Chiroptera/*anatomy & histology/physiology; Cholera Toxin/pharmacokinetics; Inferior Colliculi/*cytology/physiology; Neurons/cytology/physiology; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Electrodes; Implanted
Creator
An entity primarily responsible for making the resource
Marsh Robert A; Fuzessery Zoltan M; Grose Carol D; Wenstrup Jeffrey J
Description
An account of the resource
This report describes a projection from the amygdala, a forebrain center mediating emotional expression, to the inferior colliculus (IC), the midbrain integration center of the ascending auditory system. In the IC of mustached bats (Pteronotus parnellii) and pallid bats (Antrozous pallidus), we placed deposits of retrograde tracers at physiologically defined sites and then searched for retrogradely labeled somata in the forebrain. Labeling was most sensitive in experiments using cholera toxin B-subunit as tracer. We consistently observed retrograde labeling in a single amygdalar subdivision, the magnocellular subdivision of the basal nucleus (Bmg). The Bmg is distinctive across mammals, containing the largest cells in the amygdala and the most intense acetylcholinesterase staining. Labeled amygdalar cells occurred ipsilateral and contralateral to IC deposits, but ipsilateral labeling was greater, averaging 72%. Amygdalar labeling was observed after tracer deposits throughout the IC, including its central nucleus (ICC). In comparison, labeling in the auditory cortex (layer V) was heavily ipsilateral (averaging 92%). Cortical labeling depended on the location of IC deposits: dorsomedial deposits resulted in the most labeled cells, whereas ventrolateral deposits labeled few or no cortical cells. Cortical labeling occurred after several deposits in the ICC. Across experiments, the average number of labeled cells in the amygdala was similar to that in the auditory cortex, indicating that the amygdalocollicular projection is significant. The results demonstrate a direct, widespread projection from the basal amygdala to the IC. They also suggest the presence of a rapid thalamoamygdalocollicular feedback circuit that may impose emotional content onto processing of sensory stimuli at a relatively low level of an ascending sensory pathway.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/jneurosci.22-23-10449.2002" target="_blank" rel="noreferrer noopener">10.1523/jneurosci.22-23-10449.2002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Stilbamidines
2002
Acoustic Stimulation/methods
Action Potentials/physiology
Amygdala/*cytology/physiology
Animals
Auditory Cortex/cytology
Auditory Pathways/*cytology/physiology
Axonal Transport/physiology
Brain Stem/cytology
Chiroptera/*anatomy & histology/physiology
Cholera Toxin/pharmacokinetics
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dextrans
Electrodes
Fluorescent Dyes
Fuzessery Zoltan M
Grose Carol D
Implanted
Inferior Colliculi/*cytology/physiology
Marsh Robert A
NEOMED College of Medicine
Neurons/cytology/physiology
Rhodamines
Species Specificity
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.490310412" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.490310412</a>
Pages
678–692
Issue
4
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition of nerve growth factor-stimulated neurite outgrowth by methylamine-modified alpha 2-macroglobulin.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-04
Subject
The topic of the resource
alpha-Macroglobulins/metabolism/*pharmacology; Animals; Cells; Chick Embryo; Cultured; Drug Interactions; Female; Ganglia; Humans; Male; Methylamines/*pharmacology; Mice; Nerve Growth Factors/antagonists & inhibitors/metabolism/*pharmacology; Neurites/drug effects/*physiology/ultrastructure; Neurons/cytology/physiology; Placenta; Pregnancy; Spinal/physiology; Submandibular Gland
Creator
An entity primarily responsible for making the resource
Koo P H; Liebl D J
Description
An account of the resource
alpha 2-Macroglobulin (alpha 2M) is a rather ubiquitous protein in extracellular spaces of mammals. It is an inhibitor of endopeptidases, can be modified by aliphatic amines, and combines with a number of hormones/cytokines such as beta-nerve growth factor (NGF) [Koo PH, Stach RW (1989): J Neurosci Res 22:247]. The objective of this study is to compare the NGF-binding properties of methylamine-modified human alpha 2M (MA-alpha 2M) versus normal alpha 2M and their effects on the biological activity of NGF and neurite extension by embryonic chicken dorsal root ganglia. As determined by gel filtration, polyacrylamide gel electrophoresis, and equilibrium binding studies, these two forms of alpha 2M are similar in their binding affinities, with MA-alpha 2M binding about twice as much NGF as normal alpha 2M. Both normal alpha 2M and
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.490310412" target="_blank" rel="noreferrer noopener">10.1002/jnr.490310412</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
alpha-Macroglobulins/metabolism/*pharmacology
Animals
Cells
Chick Embryo
Cultured
Drug Interactions
Female
Ganglia
Humans
Journal of neuroscience research
Koo P H
Liebl D J
Male
Methylamines/*pharmacology
Mice
Nerve Growth Factors/antagonists & inhibitors/metabolism/*pharmacology
Neurites/drug effects/*physiology/ultrastructure
Neurons/cytology/physiology
Placenta
Pregnancy
Spinal/physiology
Submandibular Gland