1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1991.66.5.1538</a>
Pages
1538–1548
Issue
5
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Animals; Bicuculline/analogs & derivatives/pharmacology; Chlorides/pharmacology; Dendrites/drug effects/*physiology; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/*physiology; Hippocampus/*physiology; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials/drug effects; Models; Neurological; Neurons/drug effects/*physiology; Organophosphorus Compounds/pharmacology; Pyramidal Tracts/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABAA and late, GABAB receptor-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) and were not changed by the GABAB receptor antagonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">10.1152/jn.1991.66.5.1538</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Bicuculline/analogs & derivatives/pharmacology
Borroni A M
Chlorides/pharmacology
Dendrites/drug effects/*physiology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lambert N A
Mathematics
Membrane Potentials/drug effects
Models
Neurological
Neurons/drug effects/*physiology
Organophosphorus Compounds/pharmacology
Pyramidal Tracts/drug effects/*physiology
Quinoxalines/pharmacology
Rats
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00056.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00056.2005</a>
Pages
314–326
Issue
1
Volume
94
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-07
Subject
The topic of the resource
*Periodicity; Acoustic Stimulation/methods; Action Potentials/drug effects/physiology; Animals; Anura; Auditory Pathways/physiology; Bicuculline/pharmacology; Chiroptera; Dose-Response Relationship; Echolocation/*physiology; GABA Antagonists/pharmacology; Mesencephalon/*cytology/physiology; Neural Inhibition/drug effects/*physiology; Neurons/drug effects/*physiology; Newborn; Radiation; Reaction Time/drug effects/*physiology; Sound; Species Specificity; Time Factors
Creator
An entity primarily responsible for making the resource
Galazyuk Alexander V; Lin Wenyu; Llano Daniel; Feng Albert S
Description
An account of the resource
A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer response latencies at higher sound levels. PLS neurons are known to play a role in target ranging for echolocating bats that emit frequency-modulated sounds. We recently reported that early inhibition of unit's oscillatory discharges is critical for PLS in the inferior colliculus (IC) of little brown bats. The goal of this study was to determine in echolocating bats and in non-echolocating animals (frogs): 1) the detailed characteristics of PLS and whether PLS was dependent on sound level, frequency, and duration; 2) the time course of inhibition underlying PLS using a paired-pulse paradigm. We found that 22% of IC neurons in bats and 15% in frogs exhibited periodic discharge patterns in response to tone pulses at high sound levels. The firing periodicity was unit specific and independent of sound level and duration. Other IC neurons (28% in bats; 14% in frogs) exhibited PLS. These PLS neurons shared several response characteristics: 1) PLS was largely independent of sound frequency and 2) the magnitude of shift in first-spike latency was either duration dependent or duration tolerant. For PLS neurons, application of bicuculline abolished PLS and unmasked the unit's periodical firing pattern that served as the building block for PLS. In response to paired sound pulses, PLS neurons exhibited delay-dependent response suppression, confirming that high-threshold leading inhibition was responsible for PLS. Results also revealed the timing of excitatory and inhibitory inputs underlying PLS and its role in time-domain processing.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00056.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.00056.2005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Periodicity
2005
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Anura
Auditory Pathways/physiology
Bicuculline/pharmacology
Chiroptera
Department of Anatomy & Neurobiology
Dose-Response Relationship
Echolocation/*physiology
Feng Albert S
GABA Antagonists/pharmacology
Galazyuk Alexander V
Journal of neurophysiology
Lin Wenyu
Llano Daniel
Mesencephalon/*cytology/physiology
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/*physiology
Newborn
Radiation
Reaction Time/drug effects/*physiology
Sound
Species Specificity
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00040.2009</a>
Pages
1004–1016
Issue
2
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycinergic inhibition creates a form of auditory spectral integration in nuclei of the lateral lemniscus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-08
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects; Animals; Auditory Perception/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; GABA Antagonists/pharmacology; GABA-A Receptor Antagonists; GABA-A/metabolism; gamma-Aminobutyric Acid/metabolism; Glycine Agents/pharmacology; Glycine/*physiology; Glycine/antagonists & inhibitors/metabolism; Microelectrodes; Neural Inhibition/drug effects/*physiology; Neurons/drug effects/*physiology; Receptors; Strychnine/pharmacology
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Nataraj Kiran; Wenstrup Jeffrey
Description
An account of the resource
For analyses of complex sounds, many neurons integrate information across different spectral elements via suppressive effects that are distant from the neurons' excitatory tuning. In the mustached bat, suppression evoked by sounds within the first sonar harmonic (23-30 kHz) or in the subsonar band (\textless23 kHz) alters responsiveness to the higher best frequencies of many neurons. This study examined features and mechanisms associated with low-frequency (LF) suppression among neurons of the lateral lemniscal nuclei (NLL). We obtained extracellular recordings from neurons in the intermediate and ventral nuclei of the lateral lemniscus, observing different forms of LF suppression related to the two above-cited frequency bands. To understand the mechanisms underlying this suppression in NLL neurons, we examined the roles of glycinergic and GABAergic input through local microiontophoretic application of strychnine, an antagonist to glycine receptors (GlyRs), or bicuculline, an antagonist to gamma-aminobutyric acid type A receptors (GABA(A)Rs). With blockade of GABA(A)Rs, neurons showed an increase in firing rate to best frequency (BF) and/or LF tones but retained LF suppression of BF sounds. For neurons that displayed LF suppression tuned to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00040.2009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Acoustic Stimulation
Action Potentials/drug effects
Animals
Auditory Perception/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
GABA Antagonists/pharmacology
GABA-A Receptor Antagonists
GABA-A/metabolism
gamma-Aminobutyric Acid/metabolism
Glycine Agents/pharmacology
Glycine/*physiology
Glycine/antagonists & inhibitors/metabolism
Journal of neurophysiology
Microelectrodes
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/*physiology
Peterson Diana Coomes
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2016.03.010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2016.03.010</a>
Pages
177–190
Volume
324
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intrinsic plasticity induced by group II metabotropic glutamate receptors via enhancement of high-threshold KV currents in sound localizing neurons.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-06
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/drug effects/physiology; Animals; Auditory Pathways/drug effects/*physiology; Brain/drug effects/physiology; Chick Embryo; Glutamic Acid/metabolism; metabotropic glutamate receptor; Metabotropic Glutamate/agonists/*metabolism; neuromodulation; Neuronal Plasticity/drug effects/*physiology; Neurons/drug effects/*physiology; nucleus laminaris; Patch-Clamp Techniques; Potassium Channels; Potassium/metabolism; Protein Kinase C/metabolism; Receptors; Sound Localization/drug effects/*physiology; Tissue Culture Techniques; Type C Phospholipases/metabolism; voltage-gated potassium channel; Voltage-Gated/*metabolism
Creator
An entity primarily responsible for making the resource
Hamlet W R; Lu Y
Description
An account of the resource
Intrinsic plasticity has emerged as an important mechanism regulating neuronal excitability and output under physiological and pathological conditions. Here, we report a novel form of intrinsic plasticity. Using perforated patch clamp recordings, we examined the modulatory effects of group II metabotropic glutamate receptors (mGluR II) on voltage-gated potassium (KV) currents and the firing properties of neurons in the chicken nucleus laminaris (NL), the first central auditory station where interaural time cues are analyzed for sound localization. We found that activation of mGluR II by synthetic agonists resulted in a selective increase of the high-threshold KV currents. More importantly, synaptically released glutamate (with reuptake blocked) also enhanced the high-threshold KV currents. The enhancement was frequency-coding region dependent, being more pronounced in low-frequency neurons compared to middle- and high-frequency neurons. The intracellular mechanism involved the Gbetagamma signaling pathway associated with phospholipase C and protein kinase C. The modulation strengthened membrane outward rectification, sharpened action potentials, and improved the ability of NL neurons to follow high-frequency inputs. These data suggest that mGluR II provides a feedforward modulatory mechanism that may regulate temporal processing under the condition of heightened synaptic inputs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2016.03.010" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2016.03.010</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Auditory Pathways/drug effects/*physiology
Brain/drug effects/physiology
Chick Embryo
Department of Anatomy & Neurobiology
Glutamic Acid/metabolism
Hamlet W R
Lu Y
metabotropic glutamate receptor
Metabotropic Glutamate/agonists/*metabolism
NEOMED College of Medicine
neuromodulation
Neuronal Plasticity/drug effects/*physiology
Neurons/drug effects/*physiology
Neuroscience
nucleus laminaris
Patch-Clamp Techniques
Potassium Channels
Potassium/metabolism
Protein Kinase C/metabolism
Receptors
Sound Localization/drug effects/*physiology
Tissue Culture Techniques
Type C Phospholipases/metabolism
voltage-gated potassium channel
Voltage-Gated/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2011.01.075" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2011.01.075</a>
Pages
145–149
Issue
3
Volume
492
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
mGluRs modulate neuronal firing in the auditory midbrain.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/drug effects/*physiology; Animals; Auditory Perception/drug effects/physiology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Glutamic Acid/physiology; Inbred CBA; Inferior Colliculi/drug effects/metabolism/*physiology; Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology; Mice; Neural Inhibition/drug effects/physiology; Neurons/drug effects/*physiology; Perceptual Masking/physiology; Receptors; Synaptic Transmission/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Voytenko S V; Galazyuk A V
Description
An account of the resource
The mechanisms underlying sound-evoked suppression of neuronal firing in the auditory system are poorly understood. To explore these mechanisms in the inferior colliculus (IC), agonists and antagonists targeting different groups of metabotropic glutamate receptors (mGluRs) were applied iontophoretically to IC neurons in awake mice. We found that a group I-specific mGluR agonist predominantly increased neuronal firing in 52% of neurons, whereas group I antagonist had the opposite effect in 51% of neurons. A group II specific agonist showed no effect on neuronal firing but an antagonist increased firing rate in 48% of neurons. Neither a group III-specific mGluR agonist nor an antagonist had an effect on neuronal firing in the IC. We also found that sound stimuli triggered suppression of spontaneous firing in 70% of IC neurons. This suppression was reversibly blocked by group I mGluR antagonists. There is a possible link between this suppression and two perceptual phenomena: forward masking and "residual inhibition," the brief reduction/elimination of tinnitus following an appropriate masking sound.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2011.01.075" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2011.01.075</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Acoustic Stimulation/methods
Action Potentials/drug effects/*physiology
Animals
Auditory Perception/drug effects/physiology
Department of Anatomy & Neurobiology
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Galazyuk A V
Glutamic Acid/physiology
Inbred CBA
Inferior Colliculi/drug effects/metabolism/*physiology
Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology
Mice
NEOMED College of Medicine
Neural Inhibition/drug effects/physiology
Neurons/drug effects/*physiology
Neuroscience letters
Perceptual Masking/physiology
Receptors
Synaptic Transmission/drug effects/physiology
Voytenko S V